FlyBase Gene Report: Dmel\NimC3

General Information

Symbol

Dmel\NimC3

Species

D. melanogaster

Name

Nimrod C3

Annotation Symbol

CG16880

Feature Type

protein_coding_gene

FlyBase ID

FBgn0001967

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Nimrod C3 (NimC3) encodes a member of the highly conserved Nimrod cluster. It is a transmembrane protein with a putative phagocytosis receptor function. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

l(2)br30, br30, BG:DS05899.2 , l(2)34Fa, l(2)k00811

Key Links

Genomic Location

Cytogenetic map

34F1-34F1

Sequence location

2L:14,019,357..14,020,208 [-]

Recombination map

2-50

RefSeq locus

NT_033779 REGION:14019357..14020208

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (2 terms)

Molecular Function (0 terms)

There is no information supporting a Molecular Function term for this gene. (Based on a review of available data on: 2013-03-14 )

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in phagocytosis

inferred from sequence or structural similarity with FLYBASE:NimC1; FB:FBgn0259896

(Kurucz et al., 2007)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in integral component of membrane

inferred from sequence model

(FlyBase Curators, 2011-)

Gene Group (FlyBase)

NIMROD-TYPE RECEPTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Nimrod C3 (NimC3) encodes a member of the highly conserved Nimrod cluster. It is a transmembrane protein with a putative phagocytosis receptor function. [Date last reviewed: 2019-03-14]

Gene Group (FlyBase)

NIMROD-TYPE RECEPTORS -: The Nimrod family of genes is characterised by the presence of NIM repeats, closely related to the EGF-repeat. They encode proteins which are secreted or integral to the plasma membrane. The Nimrod genes have been linked to the innate immune response and some members of this family have been shown to act as receptors for bacterial or apoptic cell phagocytosis. (Adapted from FBrf0212245).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\NimC3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.42

Gene model reviewed during 5.43

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

NimC3-RB

FBtr0290243

NM_080189

852

224

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

NimC3-PB

FBpp0288682

25.3

224

6.17

NP_524928

AAF53369

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VJU2

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\NimC3 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

NimC3_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\NimC3 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\NimC3

View exonic expression by tissue for Dmel\NimC3

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB

48772/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0001967

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG16880-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG16880

Flygut - An atlas of the Drosophila adult midgut

FBgn0001967

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of NimC3

Transgenic constructs containing regulatory region of NimC3

Aberrations (Deficiencies and Duplications) ( 133 )

Inferred from experimentation ( 133 )

Gene disrupted in

Df(2L)A47

(Fossett et al., 1994, Gubb et al., 1990, Ashburner et al., 1982)

Df(2L)A263

(Ashburner et al., 1982)

Df(2L)A376

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)Adh-nBR41

(Roote et al., 1996)

Df(2L)Adh-nBR101

(Fossett et al., 1994)

Df(2L)Adh-nBR130

(Fossett et al., 1994)

Df(2L)Adh-nBR131

(Roote, 1996.1.11, Roote, 1996.8)

Df(2L)b75

(Gubb et al., 1990)

Df(2L)b77c

(Roote, 2000.7.3, Alexandrova et al., 1996)

Df(2L)b79b3

(Alexandrova et al., 1996, Roote, 1995.3.27)

Df(2L)b81f1A

(Roote, 1995.3.27)

Df(2L)b81f2A

(Alexandrova et al., 1996)

Df(2L)b84h14

(Alexandrova et al., 1996, Roote, 1995.3.27)

Df(2L)b84h50

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2L)b85c1

(Alexandrova et al., 1996, Roote, 1995.3.27)

Df(2L)b87g23

(Alexandrova et al., 1996)

Df(2L)b88f40

(Roote, 2000.6.5, Roote, 2000.7.3)

Df(2L)b88f43

(Roote, 1996.8, Roote, 1995.3.27)

Df(2L)b88g96

(Roote, 1996.8, Roote, 1995.3.27)

Df(2L)b89e8

(Roote, 2000.6.5, Roote, 2000.7.3)

Df(2L)b89e64b

(Roote, 2000.6.5)

Df(2L)b89e72

(Roote, 2000.6.5, Roote, 2000.7.3)

(Roote, 2000.6.5)

(Roote, 1998.3.17)

(Roote, 1995.5.13)

(Ryder, 2004.4.26)

(Ashburner et al., 1982)

Df(2L)fn12

(Ashburner et al., 1982)

Df(2L)fn26

(Ashburner et al., 1982)

Df(2L)fn30

(Ashburner et al., 1982)

Df(2L)fn31

(Ashburner et al., 1982)

Df(2L)GT4

(Roote et al., 1996, Gubb et al., 1990)

Df(2L)GT5

(Gubb et al., 1990)

Df(2L)k07245^Lk00811^R-mr2

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr3

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr4

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr5

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr6

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr7

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr8

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr10

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr11

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr13

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr14

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr15

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr16

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr17

(Roote, 2000.6.13)

Df(2L)k07245^Lk05605^R-mr6

(Roote, 2000.6.13)

Df(2L)k07245^Lk05605^R-mr8

(Roote, 2000.6.13)

Df(2L)noc10

(Roote et al., 1996)

Df(2L)noc20

(Roote et al., 1996)

Df(2L)osp141

(Roote et al., 1996)

Df(2L)rN149-rv3

(Roote, 2000.6.13)

Df(2L)Sco^rv23

(Ashburner and Harrington, 1984)

Df(2L)TE35B-3

(Roote et al., 1996, Gubb et al., 1985)

Df(2L)TE35B-4

(Roote et al., 1996, Gubb et al., 1985)

Df(2L)TE35B-5

(Gubb et al., 1985)

Df(2L)TE35B-8

(Roote et al., 1996, Gubb et al., 1985)

Df(2L)TE35B-9

(Roote et al., 1996, Gubb et al., 1985)

Df(2L)TE35BC-6

(Gubb et al., 1984)

Df(2L)TE35BC-23

(Gubb et al., 1984)

Df(2L)TE35BC-29

(Gubb et al., 1984)

Df(2L)TE35BC-31

(Gubb et al., 1984)

Df(2L)W

(Roote et al., 1996)

Gene duplicated in

Dp(2;1;3;f)Sco^rv23-X6

Dp(2;1;f)Sco^rv23-X2

Dp(2;1)Sco^rv23

(Ashburner and Harrington, 1984)

Dp(2;Y)b88b15

(Roote, 1996.8)

Gene partially disrupted in

Df(2L)el20

(Ashburner et al., 1999.10.12)

Gene not disrupted in

Df(2L)A48

(Fossett et al., 1994, Gubb et al., 1990, Ashburner et al., 1982)

Df(2L)A63

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A72

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A178

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A215

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A217

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A220

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A245

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A246

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A260

(Ashburner et al., 1982)

Df(2L)A264

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A266

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A267

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A337

(Fossett et al., 1994)

Df(2L)A377

(Ashburner et al., 1982)

Df(2L)A379

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A400

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A445

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)Adh-nBR100

(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)

Df(2L)Adh-nBR102

(Fossett et al., 1994)

Df(2L)Adh-nBR103

(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)

Df(2L)Adh-nBR105

(Fossett et al., 1994)

Df(2L)Adh-nBR106

(Fossett et al., 1994)

Df(2L)Adh-nBR107

(Fossett et al., 1994)

Df(2L)Adh-nBR117

(Fossett et al., 1994)

Df(2L)Adh-nBR118

(Fossett et al., 1994)

Df(2L)Adh-nBR119

(Fossett et al., 1994)

Df(2L)Adh-nBR120

(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)

Df(2L)Adh-nBR121

(Fossett et al., 1994)

Df(2L)Adh-nBR122

(Fossett et al., 1994)

Df(2L)Adh-nBR125

(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)

Df(2L)Adh-nBR126

(Fossett et al., 1994)

Df(2L)Adh-nBR127

(Fossett et al., 1994)

Df(2L)Adh-nBR128

(Fossett et al., 1994)

Df(2L)Adh-nBR129

(Fossett et al., 1994)

Df(2L)Adh-nBR131

(Fossett et al., 1994)

Df(2L)b80c1

(Ashburner et al., 1982)

Df(2L)b91l5

(Roote, 2000.7.3)

Df(2L)fn1

(Ashburner et al., 1982)

Df(2L)fn2

(Ashburner et al., 1982)

Df(2L)fn3

(Ashburner et al., 1982)

Df(2L)fn5

(Ashburner et al., 1982)

Df(2L)fn15

(Ashburner et al., 1982)

Df(2L)fn27

(Ashburner et al., 1982)

Df(2L)fn36

(Ashburner et al., 1982)

Df(2L)osp38

(Roote, 1996.8)

Df(2L)TE35B-1

(Gubb et al., 1985)

Df(2L)TE35B-2

(Gubb et al., 1985)

Df(2L)TE35B-6

(Gubb et al., 1985)

Df(2L)TE35B-7

(Gubb et al., 1985)

Df(2L)TE35B-10

(Gubb et al., 1985)

Df(2L)TE35B-11

(Gubb et al., 1985)

Df(2L)TE35B-12

(Gubb et al., 1985)

Df(2L)TE35B-15

(Gubb et al., 1985)

Df(2L)TE35BC-1

(Gubb et al., 1984)

Df(2L)TE35BC-3

(Gubb et al., 1984)

Df(2L)TE35BC-4

(Gubb et al., 1984)

Df(2L)TE35BC-7

(Gubb et al., 1984)

Df(2L)TE35BC-8

(Gubb et al., 1984)

Df(2L)TE35BC-24

(Gubb et al., 1984)

Df(2L)TE35BC-28

(Gubb et al., 1984)

Df(2L)TE35BC-34

(Gubb et al., 1984)

Df(2L)TE35BC-35

(Gubb et al., 1984)

In(2L)TE35B-13

(Gubb et al., 1985)

T(2;3)H147

(Roote, 1997.6.2)

Tp(2;2)A446

(Fossett et al., 1994, Ashburner et al., 1982)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

NimC3^GD12708

viable, with Scer\GAL4^Mef2.PR

NimC3^GD12708

viable, with Scer\GAL4^pnr-MD237

NimC3^GD12708

Other Phenotypes

Allele

abnormal immune response | adult stage, with Scer\GAL4^Hml.Δ

NimC3^GD12708

short lived | conditional, with Scer\GAL4^Hml.Δ

NimC3^GD12708

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (15)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CCBE1

1 of 15

Yes

Hsap\DKK1

1 of 15

Yes

Hsap\DKK2

1 of 15

Yes

Hsap\DKK3

1 of 15

Yes

Hsap\DKK4

1 of 15

Yes

Hsap\ESM1

1 of 15

Yes

Hsap\MEGF6

1 of 15

Yes

Hsap\MEGF10

1 of 15

Yes

Hsap\MEGF11

1 of 15

Yes

Hsap\PEAR1

1 of 15

Yes

Hsap\SCARF1

1 of 15

Yes

Hsap\SCARF2

1 of 15

Yes

Hsap\STAB1

1 of 15

Yes

Hsap\STAB2

1 of 15

Yes

Hsap\TNFAIP6

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (16)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ccbe1

1 of 15

Yes

Mmus\Dkk1

1 of 15

Yes

Mmus\Dkk2

1 of 15

Yes

Mmus\Dkk3

1 of 15

Yes

Mmus\Dkk4

1 of 15

Yes

Mmus\Egfem1

1 of 15

Yes

Mmus\Esm1

1 of 15

Yes

Mmus\Megf6

1 of 15

Yes

Mmus\Megf10

1 of 15

Yes

Mmus\Megf11

1 of 15

Yes

Mmus\Pear1

1 of 15

Yes

Mmus\Scarf1

1 of 15

Yes

Mmus\Scarf2

1 of 15

Yes

Mmus\Stab1

1 of 15

Yes

Mmus\Stab2

1 of 15

Yes

Mmus\Tnfaip6

1 of 15

Yes

Rattus norvegicus (Norway rat) (14)

Rnor\Dkk1

1 of 13

Yes

Rnor\Dkk2

1 of 13

Yes

Rnor\Dkk3

1 of 13

Yes

Rnor\Dkk4

1 of 13

Yes

Rnor\Esm1

1 of 13

Yes

Rnor\LOC100911486

1 of 13

Yes

Rnor\Megf6

1 of 13

Yes

Rnor\Megf10

1 of 13

Yes

Rnor\Megf11

1 of 13

Yes

Rnor\Pear1

1 of 13

Yes

Rnor\Scarf2

1 of 13

Yes

Rnor\Stab1

1 of 13

Yes

Rnor\Stab2

1 of 13

Yes

Rnor\Tnfaip6

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (10)

Xtro\ccbe1

1 of 12

Yes

Xtro\dkk1

1 of 12

Yes

Xtro\dkk2

1 of 12

Yes

Xtro\dkk3

1 of 12

Yes

Xtro\esm1

1 of 12

Yes

Xtro\megf11

1 of 12

Yes

Xtro\pear1

1 of 12

Yes

Xtro\scarf2

1 of 12

Yes

Xtro\stab2

1 of 12

Yes

Xtro\tnfaip6

1 of 12

Yes

Danio rerio (Zebrafish) (16)

Drer\ccbe1

1 of 15

Yes

Drer\dkk1a

1 of 15

Yes

Drer\dkk1b

1 of 15

Yes

Drer\dkk2

1 of 15

Yes

Drer\dkk3b

1 of 15

Yes

Drer\esm1

1 of 15

Yes

Drer\megf6a

1 of 15

Yes

Drer\megf6b

1 of 15

Yes

Drer\megf10

1 of 15

Yes

Drer\megf11

1 of 15

Yes

Drer\pear1

1 of 15

Yes

Drer\scarf1

1 of 15

Yes

Drer\stab1

1 of 15

Yes

Drer\stab2

1 of 15

Yes

Drer\tnfaip6

1 of 15

Yes

Drer\zgc:158328

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (21)

Cele\C53B7.2

1 of 15

Yes

Cele\ced-1

1 of 15

Yes

Cele\D1044.7

1 of 15

Yes

Cele\dsl-1

1 of 15

Yes

Cele\dsl-2

1 of 15

Yes

Cele\dsl-3

1 of 15

Yes

Cele\dsl-5

1 of 15

Yes

Cele\dsl-6

1 of 15

Yes

Cele\dsl-7

1 of 15

Yes

Cele\F07H5.8

1 of 15

Yes

Cele\F46B3.15

1 of 15

Yes

Cele\F48E3.8

1 of 15

Yes

Cele\F56B3.2

1 of 15

Yes

Cele\far-5

1 of 15

Yes

Cele\lag-2

1 of 15

Yes

Cele\lgx-1

1 of 15

Yes

Cele\M03F4.6

1 of 15

Yes

Cele\pqn-25

1 of 15

Yes

Cele\sdz-23

1 of 15

Yes

Cele\Y41D4B.26

1 of 15

Yes

Cele\Y64G10A.7

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190F33 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA14193

Drosophila persimilis

Dper\GL21061

Drosophila willistoni

Dwil\GK15105

Drosophila virilis

Dvir\GJ18068

Drosophila mojavensis

Dmoj\GI17391

Drosophila grimshawi

Dgri\GH10602

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150BEK )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17004248

Glossina morsitans

Tsetse fly

Gmor\GMOY003158

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_00042

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )

No non-Dipteran orthologies identified

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (14)

Gene Symbol

Score

Source

Alignment

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

71674

DroID - A comprehensive database of gene and protein interactions.

FBgn0001967

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

48772

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-50

Cytogenetic map

34F1-34F1

Sequence location

2L:14,019,357..14,020,208 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

34F1-34F1

Limits computationally determined from genome sequence between P{lacW}Sos^k05224&P{lacW}RpII33^k05605 and P{lacW}l(2)34Fa^k00811&P{PZ}wb⁰⁹⁴³⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

35A1-35A2

(determined by in situ hybridisation)

(Ashburner et al., 1999, Spradling et al., 1999)

35A1-35A2

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-50

(FlyBase, 2016)

2-45.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Bloomington

17054

w¹¹¹⁸; P{EP}NimC3^EP2418

10487

y¹ w^67c23; P{lacW}NimC3^k00811/CyO

3439

NimC3¹ Adhⁿ¹ PolD3^rd-s pr¹ cn¹, l(2)CA3^CR5/CyO

Kyoto

114340

y^d2 w¹¹¹⁸ P{ey-FLP.N}2; P{lacW}NimC3^k00811 P{neoFRT}40A/CyO y⁺

VDRC

v103668

P{KK112612}VIE-260B

v22920

w¹¹¹⁸; P{GD12708}v22920

Genomic Clones (10)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0001967

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0001967

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

48772

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: nimC3 l(2)34Fa

(Kurucz et al., 2007)

Source for identity of: NimC3 nimC3

(FlyBase, 2009-)

Source for database merge of

Source for merge of: l(2)34Fa CG16880

(Misra, 2000.4.12)

Additional comments

Other Comments

Origin and Etymology

Discoverer

Etymology

The "nimrod" gene cluster is dubbed after Nimrod, the biblical "mighty hunter before the Lord" (Genesis 10), who according to Gesta Hungarorum was also the ancestor of all Hungarians (Kezai Simon, Gesta Hunnorum et Hungarorum A.D. 1282).

(Kurucz et al., 2007)

Identification

External Crossreferences and Linkouts ( 27 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

48772

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information