FlyBase Gene Report: Dmel\drpr

General Information

Symbol

Dmel\drpr

Species

D. melanogaster

Name

draper

Annotation Symbol

CG2086

Feature Type

protein_coding_gene

FlyBase ID

FBgn0027594

Gene Model Status

Current

Stock Availability

22 publicly available

Gene Summary

draper (drpr) encodes a single-pass transmembrane receptor that is involved in phagocytosis by glia, macrophages, and epithelia. It signals downstream through the proteins encoded by Src42A and Shark to promote Rac1 function and transcriptional changes through the products of Jra and Stat92E. It is also required for activation of autophagy in salivary glands. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

BcDNA:GH03529

Key Links

Genomic Location

Cytogenetic map

62B1-62B1

Sequence location

3L:1,715,595..1,731,107 [-]

Recombination map

3-1.0

RefSeq locus

NT_037436 REGION:1715595..1731107

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (23 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables phosphatidylserine binding

inferred from direct assay

(Tung et al., 2013)

enables protein binding

inferred from physical interaction with UniProtKB:Q7JUY7

(Awasaki et al., 2006)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables scavenger receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN009076277

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR042635

(InterPro Project Members, 2004-)

Biological Process (14 terms)

Terms Based on Experimental Evidence (14 terms)

CV Term

Evidence

References

involved_in apoptotic cell clearance

inferred from mutant phenotype

(Doherty et al., 2009, Kurant et al., 2008, Ziegenfuss et al., 2008)

involved_in autophagic cell death

inferred from mutant phenotype

(McPhee et al., 2010)

involved_in cell competition in a multicellular organism

inferred from mutant phenotype

(Li and Baker, 2007)

involved_in defense response to bacterium

inferred from mutant phenotype

(Hashimoto et al., 2009)

involved_in engulfment of apoptotic cell

inferred from mutant phenotype

(Etchegaray et al., 2012)

involved_in larval locomotory behavior

inferred from mutant phenotype

(Freeman et al., 2003)

involved_in neuron remodeling

inferred from mutant phenotype

(Hoopfer et al., 2006)

inferred from mutant phenotype

(Awasaki et al., 2006)

involved_in phagocytosis, engulfment

inferred from mutant phenotype

(Tasdemir-Yilmaz and Freeman, 2014, Logan et al., 2012)

involved_in phagocytosis

inferred from mutant phenotype

(Szabó et al., 2023, Hashimoto et al., 2009, Manaka et al., 2004)

involved_in positive regulation of phagocytosis, engulfment

inferred from mutant phenotype

(Han et al., 2014)

involved_in regulation of neuromuscular junction development

inferred from mutant phenotype

(Fuentes-Medel et al., 2009)

involved_in response to axon injury

inferred from mutant phenotype

(MacDonald et al., 2006)

inferred from mutant phenotype

(Neukomm et al., 2014)

involved_in response to wounding

inferred from genetic interaction with FLYBASE:Pez; FB:FBgn0031799

(Campbell et al., 2021)

involved_in wing disc dorsal/ventral pattern formation

inferred from genetic interaction with FLYBASE:Bx; FB:FBgn0265598,FLYBASE:ap; FB:FBgn0267978

(Bejarano et al., 2008)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in engulfment of apoptotic cell

inferred from biological aspect of ancestor with PANTHER:PTN002372116

(GO Reference Genome Project, 2011-)

involved_in phagocytosis

traceable author statement

(Evans et al., 2003)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in axon

inferred from mutant phenotype

(MacDonald et al., 2006)

located_in cytoplasm

inferred from direct assay

(Etchegaray et al., 2012)

located_in plasma membrane

inferred from direct assay

(Etchegaray et al., 2012, Freeman et al., 2003)

located_in postsynapse

inferred from mutant phenotype

(Fuentes-Medel et al., 2009)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in membrane

non-traceable author statement

(Manaka et al., 2004)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN009076277

(GO Reference Genome Project, 2011-)

located_in plasma membrane

inferred from experiment

(Kurant et al., 2008)

located_in postsynaptic membrane

inferred from experiment

(Etchegaray et al., 2012, Fuentes-Medel et al., 2009)

Gene Group (FlyBase)

NIMROD-TYPE RECEPTORS

Protein Family (UniProt)

Belongs to the MEGF family. (Q9W0A0)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

NIMROD-TYPE RECEPTORS -: The Nimrod family of genes is characterised by the presence of NIM repeats, closely related to the EGF-repeat. They encode proteins which are secreted or integral to the plasma membrane. The Nimrod genes have been linked to the innate immune response and some members of this family have been shown to act as receptors for bacterial or apoptic cell phagocytosis. (Adapted from FBrf0212245).

Protein Function (UniProtKB)

Receptor which is involved in the phagocytosis of a variety of cells including apoptotic cells, severed and pruned axons, degenerating dendrites, salivary gland cells, germline cells and bacteria (PubMed:15342648, PubMed:16772168, PubMed:16772169, PubMed:18984163, PubMed:20577216, PubMed:22992958, PubMed:24412417). Binds to the ligand prtp which relocates from the endoplasmic reticulum to the cell surface during apoptosis (PubMed:19927123, PubMed:23337816). Ligand-binding may promote tyrosine phosphorylation mediated by Src42a, interaction with shark and subsequent activation of phagocytosis (PubMed:18432193). Also binds to the membrane phospholipid phosphatidylserine which is exposed on the surface of apoptotic cells (PubMed:23420848). Required for the phagocytosis of apoptotic cells by macrophages (PubMed:15342648). Also required for the phagocytosis of apoptotic neurons by glial cells in the embryonic nervous system (PubMed:12765609). Acts downstream of NimC4/simu in the glial phagocytosis of apoptotic neurons (PubMed:18455990). Plays a role in the glial engulfment of larval axons as part of programmed axon pruning during metamorphosis (PubMed:16772168, PubMed:16772170). Also mediates glial cell clearance of severed axons following axonal injury (PubMed:16772169, PubMed:27498858). Required for the engulfment of degenerating dendrites by epidermal cells (PubMed:24412417). Required in the ovary for the engulfment and subsequent processing of dying germline cells by follicular epithelial cells through activation of the JNK/bsk pathway (PubMed:22992958, PubMed:27347682). Plays a role in neuromuscular junction development by mediating the clearance of presynaptic debris and immature boutons which are shed by growing synapses (PubMed:19707574). Required for larval salivary gland cell death which occurs following a rise in steroid levels after puparium formation (PubMed:20577216). Also involved in bacterial phagocytosis (PubMed:18984163). Required for hemocyte phagocytosis of the Gram-positive bacterium S.aureus (PubMed:19890048). Lipoteichoic acid, synthesized by the S.aureus lipoteichoic acid synthase ltaS, acts as a ligand for drpr in this process (PubMed:19890048). Together with Src42a and shark, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark (PubMed:26028435). Also required for macrophage priming which occurs following phagocytosis of apoptotic cells and ensures that macrophages develop a form of molecular memory that allows them to later mount an inflammatory response to tissue damage and bacterial infection (PubMed:27212238). Is also an essential factor in the regulation of muscle development and myogenesis, and as a consequence is required for normal locomotion (PubMed:12765609, PubMed:25111228, Ref.27). Likely to control the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (PubMed:25111228, PubMed:30802937, Ref.27).

(UniProt, Q9W0A0)

Summary (Interactive Fly)

encoding an EGF-repeat single-pass transmembrane domain receptor - required during metamorphosis for recognition and engulfment of degenerating axon branches by glia

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\drpr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W0A0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.41

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

drpr-RA

FBtr0072798

NM_058102

3206

594

drpr-RB

FBtr0072799

NM_167911

4517

1031

drpr-RC

FBtr0309845

NM_001259620

3298

528

drpr-RD

FBtr0334078

NM_001274346

3148

613

drpr-RE

FBtr0334079

NM_001274347

4435

1042

drpr-RF

FBtr0334080

NM_001274348

4757

976

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

drpr-PA

FBpp0072680

66.2

594

6.51

FBpp0072681

113.0

1031

5.96

FBpp0301579

58.7

528

6.69

FBpp0306203

68.3

613

6.48

FBpp0306204

114.3

1042

6.01

FBpp0306205

106.8

976

6.10

M9PBI3

NP_001261277

AGB93972

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts (via the cytoplasmic domain) with shark; this is required for the recruitment of drpr and glial cells to severed axons and for the phagocytosis of axonal debris by glial cells following axon injury (PubMed:18432193). Interacts with ced-6 (PubMed:16772168).

(UniProt, Q9W0A0)

Post Translational Modification

Phosphorylated on tyrosine residues (PubMed:18432193, PubMed:19927123, PubMed:23337816, PubMed:23420848). Phosphorylation is induced by binding to prtp (PubMed:19927123). It is also induced by binding to the membrane phospholipid phosphatidylserine (PubMed:23420848). Phosphorylation may be mediated directly or indirectly by Src42a and is required for interaction with shark (PubMed:18432193).

(UniProt, Q9W0A0)

Domain

Isoform B: The intracellular domain is required for glial engulfment activity. Isoform A: The intracellular domain contains an 11-residue insertion compared to isoform B and is incapable of promoting glial engulfment.

(UniProt, Q9W0A0)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\drpr using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

drpr_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.96

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult fat body

Comment: cyclical, peak ZT13-16

(Xu et al., 2011)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 15

embryonic/larval plasmatocyte

(Weavers et al., 2016)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

third instar larval stage

glial cell | subset of brain | faint

(Awasaki et al., 2006)

prepupal stage P3

glial cell | subset of brain

Comment: 6h APF

(Awasaki et al., 2006)

prepupal stage P4(ii)

glial cell | subset of brain | faint

Comment: 12h APF

(Awasaki et al., 2006)

Additional Descriptive Data

Naive stage 11 macrophages have low levels of drpr transcripts and protein that increase after corpse uptake.

(Weavers et al., 2016)

Expressed cyclically in the adult fat body.

(Xu et al., 2011)

drpr transcript is detected in a subset of glial cells that surround the distal tip of the mushroom body vertical lobes.

(Awasaki et al., 2006)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

peripheral perisynaptic glial cell

(Fuentes-Medel et al., 2009)

prepupal stage P2 -- P3

astrocyte-like glial cell of neuropil

(Tasdemir-Yilmaz and Freeman, 2014)

prepupal stage P3

glial cell | subset of brain

Comment: 6h APF

(Awasaki et al., 2006)

mushroom body vertical lobe | restricted

Comment: 6h APF

(Awasaki et al., 2006)

prepupal stage P3 -- P4

embryonic/larval salivary gland

(McPhee et al., 2010)

adult stage

glial cell of adult brain

(MacDonald et al., 2006)

glial cell of adult antennal lobe

(MacDonald et al., 2006)

adult brain cell body glial cell of adult antennal lobe

Comment: up-regulated in response to axotomy

(Doherty et al., 2014, Doherty et al., 2009)

adult ensheathing glial cell of adult antennal lobe

(Doherty et al., 2009)

adult ensheathing glial cell

(Doherty et al., 2014)

adult brain cell body glial cell

(Doherty et al., 2014)

adult stage | male

cyst cell of testis

(Zohar-Fux et al., 2022)

oogenesis

follicle cell | subset

Comment: in dying egg chambers

(Etchegaray et al., 2012)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 15

embryonic/larval plasmatocyte

(Weavers et al., 2016)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain

(Doherty et al., 2014)

Additional Descriptive Data

drpr protein was detected on the membranes of cyst cells that encapsulate spermatogonia. drpr-labeled protrusions extending from cyst cells into dying germ cells were observed.

(Zohar-Fux et al., 2022)

Naive stage 11 macrophages have low levels of drpr transcripts and protein that increase after corpse uptake.

(Weavers et al., 2016)

drpr protein is expressed in the follicle cells of dying egg chambers. drpr protein levels increase in follicle cells as engulfment of nurse cells by follicle cells in dying egg chambers proceeds.

(Etchegaray et al., 2012)

Some drpr isoforms are present at low levels in salivary glands and localize to the luminal/apical region at 6h APF. Following the rise in steroid levels that triggers cell death at 12h APF, drpr levels increase and remain high up to 14h APF, when some of the drpr changes from an apical to a cytoplasmic localization.

(McPhee et al., 2010)

drpr protein is detected in a subset of glial cells that surround the distal tip of the mushroom body vertical lobes. These cells also express ced-6 protein. Expression in also detected in glial processes that infiltrate the vertical lobes.

(Awasaki et al., 2006)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in axon

inferred from mutant phenotype

(MacDonald et al., 2006)

located_in cytoplasm

inferred from direct assay

(Etchegaray et al., 2012)

located_in plasma membrane

inferred from direct assay

(Etchegaray et al., 2012, Freeman et al., 2003)

located_in postsynapse

inferred from mutant phenotype

(Fuentes-Medel et al., 2009)

Expression Deduced from Reporters

Reporter: P{drpr-GAL4.ee7.MUT}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body glial cell

Comment: up-regulated in response to axotomy

(Doherty et al., 2014)

adult brain cell body glial cell of adult antennal lobe

Comment: up-regulated in response to axotomy

(Doherty et al., 2014)

astrocyte-like glial cell | faint

(Doherty et al., 2014)

adult ensheathing glial cell

Comment: up-regulated in response to axotomy

(Doherty et al., 2014)

Reporter: P{drpr-GAL4.ee7}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body glial cell

Comment: up-regulated in response to axotomy

(Doherty et al., 2014)

adult brain cell body glial cell of adult antennal lobe

Comment: up-regulated in response to axotomy

(Doherty et al., 2014)

astrocyte-like glial cell | faint

(Doherty et al., 2014)

adult ensheathing glial cell

Comment: up-regulated in response to axotomy

(Doherty et al., 2014)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\drpr in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\drpr

View exonic expression by tissue for Dmel\drpr

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027594

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38218/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0027594

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0027594

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0027594

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2086

Flygut - An atlas of the Drosophila adult midgut

FBgn0027594

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\drpr

Stages(s) 1-3
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 22 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 35 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of drpr

Transgenic constructs containing regulatory region of drpr

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene partially disrupted in

Df(3L)drpr^Δ5

(Draper et al., 2014)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of larval stage

drpr^EP522

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Other Phenotypes

Allele

abnormal cell death | adult stage | germline clone | nutrition conditional

drpr^Δ5

abnormal cell death | adult stage | nutrition conditional

drpr^Δ5

abnormal cell death | adult stage | nutrition conditional, with Scer\GAL4^GR1

drpr^RNAi.UAS

abnormal immune response | conditional

drpr^Δ5

abnormal locomotor behavior | adult stage

drpr^Δ5

abnormal locomotor behavior | adult stage, with Scer\GAL4^Act5C.PI

drpr^GD14423

abnormal locomotor behavior | adult stage, with Scer\GAL4^how-24B

drpr^GD14423

abnormal locomotor behavior | adult stage, with Scer\GAL4^twi.PG

drpr^GD14423

abnormal locomotor behavior | adult stage | progressive | recessive

drpr^Δ5

abnormal locomotor behavior | larval stage

drpr^EP522

abnormal locomotor behavior | third instar larval stage

drpr^Δ5

abnormal neuroanatomy

drpr^Δ5

abnormal neuroanatomy, with Scer\GAL4^alrm.PD

drpr^RNAi.UAS

abnormal neuroanatomy, with Scer\GAL4^repo.PU

drpr^RNAi.UAS

abnormal neuroanatomy | adult stage

drpr^Δ5

abnormal neuroanatomy | adult stage | conditional

drpr^Δ5

abnormal neuroanatomy | adult stage | conditional, with Scer\GAL4^GMR56F03

abnormal neuroanatomy | adult stage | conditional, with Scer\GAL4^repo

abnormal neuroanatomy | conditional, with Scer\GAL4^Gli-rL82

drpr^RNAi.UAS

abnormal neuroanatomy | conditional, with Scer\GAL4^nrv2.PS

drpr^RNAi.UAS

abnormal neuroanatomy | conditional, with Scer\GAL4^repo

drpr^RNAi.UAS

abnormal neuroanatomy | conditional, with Scer\GAL4^VGlut1-OK371

drpr^Δ5

abnormal neuroanatomy | larval stage

drpr^indel

abnormal neuroanatomy | larval stage | conditional, with Scer\GAL4^A58

drpr^GD2628

abnormal neuroanatomy | larval stage | conditional (with Df(3L)BSC181)

drpr^Δ5

abnormal neuroanatomy | P-stage

abnormal neuroanatomy | P-stage, with Scer\GAL4^repo

drpr^RNAi.UAS.cAa

abnormal neuroanatomy | pupal stage

drpr^Δ5

abnormal neuroanatomy | pupal stage, with Scer\GAL4^en-e16E

drpr^GD2628

abnormal neuroanatomy | pupal stage (with Df(3L)BSC181)

drpr^Δ5

abnormal neurophysiology | adult stage, with Scer\GAL4^repo

drpr^HMS01623

abnormal stress response | adult stage, with Scer\GAL4^repo

drpr^RNAi.UAS

abnormal stress response | adult stage | somatic clone

drpr^Δ5

abnormal stress response | larval stage

drpr^indel

abnormal stress response | larval stage, with Spyo\Cas9^shot.PJ

drpr^U6:3.gRNA

abnormal wound healing | embryonic stage

drpr^Δ5

decreased occurrence of cell division | spermatogenesis

drpr^Δ5

hyperplasia | spermatogenesis

drpr^Δ5

increased cell death | adult stage, with Scer\GAL4^GR1

drpr^I.UAS

increased cell death | larval stage

drpr^Δ5

increased size | larval stage

drpr^indel

short lived | recessive

drpr^Δ5

some die during larval stage

drpr^EP522

uncoordinated | larval stage

drpr^EP522

Phenotype manifest in

Allele

adult brain

drpr^Δ5

adult brain, with Scer\GAL4^Act5C.PI

drpr^GD14423

adult ensheathing glial cell, with Scer\GAL4^Mz709

drpr^RNAi.UAS

adult ensheathing glial cell, with Scer\GAL4^repo.PU

drpr^RNAi.UAS

adult ensheathing glial cell | conditional, with Scer\GAL4^GMR56F03

adult mushroom body

drpr^Δ5

adult olfactory receptor neuron

drpr^Δ5

adult olfactory receptor neuron, with Scer\GAL4^repo.PU

drpr^RNAi.UAS

adult olfactory receptor neuron Or42a | conditional

drpr^Δ5

adult olfactory receptor neuron Or42a | conditional, with Scer\GAL4^GMR56F03

drpr^HMS01623

adult olfactory receptor neuron Or42a | conditional, with Scer\GAL4^repo

antennal lobe glomerulus VM7 | adult stage | conditional, with Scer\GAL4^GMR56F03

antennal lobe glomerulus VM7 | conditional

drpr^Δ5

antennal lobe glomerulus VM7 | conditional, with Scer\GAL4^GMR56F03

drpr^HMS01623

antennal lobe glomerulus VM7 | conditional, with Scer\GAL4^repo

drpr^HMS01623

astrocyte-like glial cell

drpr^Δ5

astrocyte-like glial cell, with Scer\GAL4^alrm.PD

drpr^RNAi.UAS

axon | adult stage, with Scer\GAL4^repo

drpr^RNAi.UAS

axon | adult stage | conditional, with Scer\GAL4^GMR56F03

drpr^HMS01623

axon | adult stage | conditional, with Scer\GAL4^repo

axon | adult stage | somatic clone

drpr^Δ5

cyst cell of testis

drpr^Δ5

dendrite

drpr^Δ5

dendrite | larval stage

drpr^indel

dendrite | larval stage, with Spyo\Cas9^shot.PJ

drpr^U6:3.gRNA

dendrite | P-stage

egg chamber

drpr^Δ5

egg chamber | germline clone | nutrition conditional

drpr^Δ5

egg chamber | nutrition conditional

drpr^Δ5

egg chamber | nutrition conditional, with Scer\GAL4^GR1

drpr^RNAi.UAS

embryonic/larval hemocyte

drpr^Δ5

embryonic/larval plasmatocyte | larval stage

drpr^Δ5

embryonic/larval salivary gland

drpr^Δ5

embryonic/larval salivary gland, with Scer\GAL4^fkh.PH

filamentous actin | adult stage | conditional, with Scer\GAL4^repo

drpr^HMS01623

follicle cell | nutrition conditional

drpr^Δ5

follicle cell | nutrition conditional, with Scer\GAL4^GR1

drpr^RNAi.UAS

gamma Kenyon cell

drpr^Δ5

gamma Kenyon cell, with Scer\GAL4^alrm.PD

drpr^RNAi.UAS

gamma Kenyon cell | pupal stage

drpr^Δ5

glial cell

drpr^Δ5

glial cell, with Scer\GAL4^repo

drpr^RNAi.UAS.cAa

larval central nervous system | embryonic stage

drpr^unspecified

larval dorsal multidendritic neuron ddaC

larval dorsal multidendritic neuron ddaC, with Spyo\Cas9^shot.PJ

drpr^U6:3.gRNA

larval dorsal multidendritic neuron ddaC | larval stage

drpr^indel

larval dorsal multidendritic neuron ddaC | larval stage | conditional, with Scer\GAL4^A58

drpr^GD2628

larval dorsal multidendritic neuron ddaC | larval stage | conditional (with Df(3L)BSC181)

drpr^Δ5

larval dorsal multidendritic neuron ddaC | P-stage

larval dorsal multidendritic neuron ddaC | pupal stage, with Scer\GAL4^en-e16E

drpr^GD2628

larval dorsal multidendritic neuron ddaC | pupal stage (with Df(3L)BSC181)

drpr^Δ5

larval dorsal multidendritic neuron ddaE, with Spyo\Cas9^shot.PJ

drpr^U6:3.gRNA

lysosome, with Scer\GAL4^fkh.PH

drpr^RNAi.UAS

lysosome | increased number

drpr^Δ5

mesothoracic tergotrochanter muscle cell

drpr^Δ5

mesothoracic tergotrochanter muscle cell, with Scer\GAL4^Act5C.PI

drpr^GD14423

nurse cell

drpr^Δ5

nurse cell, with Scer\GAL4^GR1

drpr^I.UAS

presynapse | adult stage | conditional, with Scer\GAL4^GMR56F03

drpr^HMS01623

presynapse | adult stage | conditional, with Scer\GAL4^repo

retina

drpr^Δ5

spermatogonium

drpr^Δ5

spermatogonium | increased number

drpr^Δ5

wing nerve, with Scer\GAL4^repo

drpr^RNAi.UAS

wing nerve | somatic clone

drpr^Δ5

wing vein L1 | conditional, with Scer\GAL4^Gli-rL82

drpr^RNAi.UAS

wing vein L1 | conditional, with Scer\GAL4^nrv2.PS

drpr^RNAi.UAS

wing vein L1 | conditional, with Scer\GAL4^repo

drpr^RNAi.UAS

wing vein L1 | conditional, with Scer\GAL4^VGlut1-OK371

drpr^Δ5

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (70)

Hsap\MEGF11

13 of 14

Yes

Hsap\MEGF10

12 of 14

Yes

Hsap\PEAR1

9 of 14

Yes

Hsap\MEGF6

4 of 14

Yes

Hsap\SCARF1

2 of 14

Yes

Hsap\SCARF2

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\DKK2

1 of 14

Yes

Hsap\DKK3

1 of 14

Yes

Hsap\DKK4

1 of 14

Yes

Hsap\DLL1

1 of 14

Hsap\ESM1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\WIF1

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (32)

Rnor\Megf10

12 of 14

Yes

Rnor\Megf11

12 of 14

Yes

Rnor\Pear1

9 of 14

Yes

Rnor\Megf6

4 of 14

Yes

Rnor\Scarf2

2 of 14

Yes

Rnor\Csf1r

1 of 14

Rnor\Dkk1

1 of 14

Yes

Rnor\Dkk2

1 of 14

Yes

Rnor\Dkk3

1 of 14

Yes

Rnor\Dkk4

1 of 14

Yes

Rnor\Esm1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Ret

1 of 14

Rnor\Scarf1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (38)

Mmus\Megf11

13 of 14

Yes

Mmus\Megf10

12 of 14

Yes

Mmus\Pear1

8 of 14

Yes

Mmus\Megf6

4 of 14

Yes

Mmus\Egfem1

2 of 14

Yes

Mmus\Scarf1

2 of 14

Yes

Mmus\Scarf2

2 of 14

Yes

Mmus\Ccbe1

1 of 14

Mmus\Csf1r

1 of 14

Mmus\Dkk1

1 of 14

Yes

Mmus\Dkk2

1 of 14

Yes

Mmus\Dkk3

1 of 14

Yes

Mmus\Dkk4

1 of 14

Yes

Mmus\Egfl6

1 of 14

Yes

Mmus\Esm1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (25)

Xtro\megf10

10 of 13

Yes

Xtro\megf11

8 of 13

Yes

Xtro\pear1

8 of 13

Yes

Xtro\adgre2

2 of 13

Yes

Xtro\fat1

1 of 13

Xtro\fbxw4

1 of 13

Xtro\gas6

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\megf6

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ubxn7

1 of 13

Xtro\XB987888

1 of 13

Yes

Xtro\XB5969698

1 of 13

Danio rerio (Zebrafish) (38)

Drer\megf11

13 of 14

Yes

Drer\pear1

12 of 14

Yes

Drer\megf10

11 of 14

Yes

Drer\megf6b

4 of 14

Yes

Drer\megf6a

3 of 14

Yes

Drer\ccbe1

1 of 14

Drer\dkk1a

1 of 14

Yes

Drer\dkk1b

1 of 14

Yes

Drer\dkk2

1 of 14

Yes

Drer\dkk3b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\scarf2

1 of 14

Yes

Drer\si:ch73-206d17.1

1 of 14

Drer\si:ch211-221n20.8

1 of 14

Yes

Drer\stab1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (56)

Cele\ced-1

11 of 14

Yes

Cele\D1044.7

2 of 14

Cele\T25F10.3

2 of 14

Yes

Cele\Y64G10A.7

2 of 14

Yes

Cele\B0252.1

1 of 14

Cele\C02B10.3

1 of 14

Cele\C53B7.2

1 of 14

Yes

Cele\cdh-4

1 of 14

Cele\clec-78

1 of 14

Cele\cpg-24

1 of 14

Yes

Cele\dsl-1

1 of 14

Yes

Cele\dsl-2

1 of 14

Yes

Cele\dsl-5

1 of 14

Yes

Cele\dsl-6

1 of 14

Yes

Cele\dsl-7

1 of 14

Yes

Cele\eat-20

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\F35D2.3

1 of 14

Yes

Cele\F40G9.8

1 of 14

Yes

Cele\F46B3.15

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (33)

Agam\AgaP_AGAP007256

12 of 12

Yes

Agam\AgaP_AGAP009760

2 of 12

Agam\AgaP_AGAP009761

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (1)

Atha\AT2G34123

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:drpr. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (34)

4 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

btl

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

htl

1 of 13

LanA

1 of 13

LanB1

1 of 13

LanB2

1 of 13

Pvr

1 of 13

shf

1 of 13

Ten-a

1 of 13

Tie

1 of 13

Wsck

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

myopathy, areflexia, respiratory distress, and dysphagia, early-onset

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

drpr^Δ5

model of myopathy

CEA

(Draper et al., 2014)

model of neurodegenerative disease

CEA

(Elguero et al., 2023)

drpr^GD14423

model of myopathy

CEA

(Draper et al., 2014)

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

MEGF10; multiple EGF like domains 10

model of congenital myopathy 10B

IEA

(FlyBase, 2019-)

model of early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 5 )

Allele

Disease

Interaction

References

drpr^RNAi.UAS

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.E693G.UAS.VTR}

(Ray et al., 2017)

exacerbates Huntington's disease

modeled by Hsap\HTT^{Q91.ex1.QUAS.mCherry}

(Pearce et al., 2015)

drpr^Δ5

model of neurodegenerative disease

is ameliorated by Rel^GD1199

(Elguero et al., 2023)

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.E693G.UAS.VTR}

(Ray et al., 2017)

exacerbates Huntington's disease

modeled by Hsap\HTT^{Q91.ex1.QUAS.mCherry}

(Pearce et al., 2015)

ameliorates Huntington's disease

modeled by Hsap\HTT^{Q25.ex1.UAS.GFP}, Hsap\HTT^{Q91.ex1.QUAS.mCherry}

(Donnelly et al., 2020)

ameliorates fragile X syndrome

modeled by Fmr1^Δ50M

(Vita et al., 2021)

drpr^I.UAS

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.E693G.UAS.VTR}

(Ray et al., 2017)

ameliorates fragile X syndrome

modeled by Fmr1^Δ50M

(Vita et al., 2021)

drpr^UAS.cUa

ameliorates amyotrophic lateral sclerosis type 8

modeled by Vap33^{P58S.UAS.Tag:FLAG}

(Sanhueza et al., 2015)

drpr^gRNA.U6

ameliorates Huntington's disease

modeled by Hsap\HTT^{Q91.ex1.UAS.pHluorinE.tdTom}

(Davis et al., 2024)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MEGF11; multiple EGF like domains 11

13 of 14

612454

MEGF10; multiple EGF like domains 10

12 of 14

612453

PEAR1; platelet endothelial aggregation receptor 1

9 of 14

610278

MEGF6; multiple EGF like domains 6

4 of 14

604266

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

drpr - CaBP1

solid phase assay, identification by antibody, affinity chromatography technology, Identification by mass spectrometry

(Okada et al., 2012)

drpr - Shark

anti tag coimmunoprecipitation, anti tag western blot, two hybrid, anti bait coimmunoprecipitation, fluorescent resonance energy transfer, fluorescence technology

(Williamson and Vale, 2018, Lu et al., 2017, Logan et al., 2012, Ziegenfuss et al., 2008)

drpr - Traf4

anti tag coimmunoprecipitation, anti tag western blot

(Lu et al., 2017)

drpr - ced-6

pull down, western blot

(Awasaki et al., 2006)

drpr - csw

anti bait coimmunoprecipitation, anti tag western blot

(Logan et al., 2012)

drpr - ctg

anti tag coimmunoprecipitation, anti tag western blot

(Sung et al., 2024)

drpr - galectin

anti tag coimmunoprecipitation, anti tag western blot

(Sung et al., 2024)

drpr - orion

colocalization, fluorescence microscopy, inferred by author

(Ji et al., 2023)

drpr - prtp

pull down, anti tag western blot, western blot, peptide massfingerprinting

(Fujita et al., 2012, Kuraishi et al., 2009)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

drpr

suppressible

Atg1

(McPhee et al., 2010)

enhanceable

(Ji et al., 2022)

enhanceable

(Zohar-Fux et al., 2022, Tasdemir-Yilmaz and Freeman, 2014)

drpr

enhanceable

Crk

(Tasdemir-Yilmaz and Freeman, 2014)

drpr

enhanceable

crq

(Zohar-Fux et al., 2022)

drpr

suppressible

hep

(Etchegaray et al., 2012)

drpr

enhanceable

Itgbn

(Nagaosa et al., 2011)

drpr

suppressible

Lamp1

(Zohar-Fux et al., 2022)

suppressible

(Ji et al., 2022)

enhanceable

(Hilu-Dadia et al., 2025)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

ap|Bx

suppressible

drpr

(Bejarano et al., 2008)

axed

enhanceable

drpr

(Ji et al., 2022)

suppressible

drpr

(Bejarano et al., 2008)

Cdc50

suppressible

drpr

(Sapar et al., 2018)

ced-6

enhanceable

drpr

(Awasaki et al., 2006)

Ced-12

enhanceable

drpr

(Zohar-Fux et al., 2022)

Itgbn

enhanceable

drpr

(Nagaosa et al., 2011)

NimC4|santa-maria

suppressible

drpr

(Hilu-Dadia et al., 2025)

suppressible

(Ji et al., 2022)

suppressible

(Shklyar et al., 2014)

santa-maria

enhanceable

drpr

(Hilu-Dadia et al., 2025)

santa-maria

suppressible

drpr

(Hilu-Dadia et al., 2025)

Sarm

suppressible

drpr

(Ji et al., 2022)

External Data

Subunit Structure (UniProtKB)

(UniProt, Q9W0A0 )

Linkouts

BioGRID - A database of protein and genetic interactions.

63751

DroID - A comprehensive database of gene and protein interactions.

FBgn0027594

MIST (protein-protein) - An integrated Molecular Interaction Database

38218

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Efferocytosis

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-1.0

Cytogenetic map

62B1-62B1

Sequence location

3L:1,715,595..1,731,107 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

62B1-62B1

Limits computationally determined from genome sequence between P{EP}rho^EP3704&P{PZ}l(3)06226⁰⁶²²⁶ and P{PZ}dlt⁰⁴²⁷⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-1.0

(FlyBase, 2016)

3-2.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (22)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

67037

w^*; P{UAS-drpr.III}2

67035

y¹ w^*; P{UAS-drpr.I}2

67036

y¹ w^*; P{UAS-drpr.II}2

22010

w¹¹¹⁸; P{EPg}drpr^HP37013

25531

w¹¹¹⁸; Mi{ET1}drpr^MB06916

67034

y¹ w^*; P{UAS-drpr.RNAi}2/CyO

2086R-1

2086R-5

v4833

w¹¹¹⁸; P{GD2628}v4833

v27086

w¹¹¹⁸; P{GD14423}v27086

v4830

w¹¹¹⁸; P{GD2628}v4830/TM3

v27084

w¹¹¹⁸; P{GD14423}v27084/TM3

More stocks available...

Genomic Clones (25)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (72)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI03750

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0027594

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0027594

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Musashe et al., 2016)

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Isoform I of drpr, but not isoforms II or III, is sufficient for glial phagocytic engulfment of degenerating axons in the adult brain.

(Logan et al., 2012)

The drpr-II isoform inhibits glial phagocytic engulfment of degenerating axons through an ITIM-like domain.

(Logan et al., 2012)

drp is required for degradation of apoptotic cells after they have been engulfed during apoptotic cell clearance by glia in the nervous system and macrophages elsewhere.

(Kurant et al., 2008)

drpr is needed in wild-type cells for the death of Minute neighbours in cell competition experiments.

(Li and Baker, 2007)

In drpr mutants glia fail to respond morphologically to axon injury, and severed axons are not cleared from the CNS.

(MacDonald et al., 2006)

drpr is involved in the phagocytosis of apoptotic cells by hemocytes/macrophages.

(Manaka et al., 2004)

Identification: by computational analysis looking for genes flanking gcm binding sites.

(Freeman et al., 2001)

Relationship to Other Genes

Source for database merge of

Source for merge of: drpr CG18172

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: BcDNA:GH03529 CG2086

(Deng, 1999.11)

Source for identity of: drpr BcDNA:GH03529

(Freeman, 2002.3.5, Freeman et al., 2001)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

BcDNA:GH03529

(Egger et al., 2002)

CED-1

(Davidson and Wood, 2020)

CG18172

(Freeman, 2002.3.5)

CG2086

(Ni et al., 2011.7.19, Perkins et al., 2009, Piacentini et al., 2009, Kurucz et al., 2007, Qin et al., 2005)

CT41022

(Hynes and Zhao, 2000)

CT6730

(Hynes and Zhao, 2000)

DRPR

(Chorna and Hasan, 2012)

Draper

(Liegeois and Ferrandon, 2022, Jeon et al., 2020, Ekowati et al., 2017, Nainu et al., 2017, Wood and Martin, 2017, Péan and Dionne, 2014, Fang and Bonini, 2012)

Draper I

(Freeman, 2015)

Drpr

(Bradic and Rewitz, 2025, Tyszka et al., 2025, Rui, 2024, Shweta et al., 2024, Aggarwal et al., 2022, Boulanger and Dura, 2022, Simões et al., 2022, Bittern et al., 2021, Furusawa and Emoto, 2021, Hilu-Dadia and Kurant, 2020, Xu et al., 2020, Etchegaray et al., 2012, Shen and Codogno, 2011, Fuentes-Medel et al., 2009)

draper

(Price et al., 2025, Li et al., 2024, Petrignani et al., 2021, Musashe et al., 2016, Levayer and Moreno, 2013, Kurant, 2011, Somogyi et al., 2010, Williams et al., 2006)

drpr

(Almeida Machado Costa et al., 2025, Bayar et al., 2025, Bischoff et al., 2025, Chen et al., 2025, Hilu-Dadia et al., 2025, Hirata et al., 2025, Perron et al., 2025, Yin et al., 2025, Berg et al., 2024, Collins et al., 2024, Salminen et al., 2024, Sung et al., 2024, Bajgar and Krejčová, 2023, Brooks et al., 2023, Chen et al., 2023, Elguero et al., 2023, Jindal et al., 2023, Voutyraki et al., 2023, Goodman and Bellen, 2022, Ji et al., 2022, Marcogliese et al., 2022, Okuda et al., 2022, Boulanger et al., 2021, Buhlman et al., 2021, Coppens et al., 2021, Gerenu et al., 2021, Hsu et al., 2021, Jay et al., 2021, Lebo and McCall, 2021, Lebo et al., 2021, Yin et al., 2021, Donnelly et al., 2020, Faber et al., 2020, Asri et al., 2019, Banerjee et al., 2019, Engel et al., 2019, Melcarne et al., 2019, Melcarne et al., 2019, Nakano et al., 2019, Saha et al., 2019, Sapar and Han, 2019, Yang and Chien, 2019, Gene Disruption Project members, 2018-, Santoso et al., 2018, Shlyakhover et al., 2018, Fochler et al., 2017, Lin et al., 2017, Lu et al., 2017, Ray et al., 2017, Eichenlaub et al., 2016, Etchegaray et al., 2016, Meehan et al., 2016, Okuda et al., 2016, Shen et al., 2016, Weavers et al., 2016, Gene Disruption Project members, 2015-, Nainu et al., 2015, Sanhueza et al., 2015, Ashwal-Fluss et al., 2014, Doherty et al., 2014, Draper et al., 2014, Han et al., 2014, Neukomm et al., 2014, Shklyar et al., 2014, Tasdemir-Yilmaz and Freeman, 2014, Lavagnino et al., 2013, Tung et al., 2013, Etchegaray et al., 2012, Fujita et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Logan et al., 2012, Okada et al., 2012, Shiratsuchi et al., 2012, Gafuik and Steller, 2011, Nagaosa et al., 2011, Xu et al., 2011, McPhee et al., 2010, Thomson and Johnson, 2010, Kuraishi et al., 2009, Martín et al., 2009, Cuttell et al., 2008, Kurant et al., 2008, Hueber et al., 2007, Kuraishi et al., 2007, Li and Baker, 2007, Zhang et al., 2007, Awasaki et al., 2006, Hoopfer et al., 2006)

Name Synonyms

Draper

(Parvez and Rahul, 2026, Brandt and Ackerman, 2025, Hirooka et al., 2025, Scopelliti et al., 2025, Coutinho-Budd et al., 2024, Heron et al., 2023, Nainu et al., 2023, Villalobos-Cantor et al., 2023, Wang et al., 2023, Bindhani et al., 2022, Nayak and Mishra, 2022, Bittern et al., 2021, Russell et al., 2021, Bolus et al., 2020, Davidson and Wood, 2020, Hilu-Dadia and Kurant, 2020, Kessissoglou et al., 2020, Kim et al., 2020, Lu et al., 2020, Stanhope et al., 2020, Younes et al., 2020, Kounatidis and Chtarbanova, 2018, Losada-Perez, 2018, Williamson and Vale, 2018, Kutscher and Shaham, 2017, Lu et al., 2017, Purice et al., 2017, Meehan et al., 2016, Parsons and Foley, 2016, Purice et al., 2016, Weavers et al., 2016, Erdmann et al., 2015, Lee and Sun, 2015, Pearce et al., 2015, Stratoulias and Heino, 2015, Vlisidou and Wood, 2015, Amoyel and Bach, 2014, Doherty et al., 2014, Han et al., 2014, Lu et al., 2014, Wang et al., 2014, Corty and Freeman, 2013, Jenkins et al., 2013, Levayer and Moreno, 2013, Macdonald et al., 2013, Etchegaray et al., 2012, Fujita et al., 2012, Igboin et al., 2012, Kounatidis and Ligoxygakis, 2012, Logan et al., 2012, Okada et al., 2012, Ziegenfuss et al., 2012, Shen and Codogno, 2011, Fernández-Ayala et al., 2010, McPhee et al., 2010, Thomson and Johnson, 2010, Fuentes-Medel et al., 2009, Kuraishi et al., 2008, Ziegenfuss et al., 2008, Kurucz et al., 2007, Kurucz et al., 2007)

Secondary FlyBase IDs

FBgn0035261

Datasets (0)

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Title

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Result

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Title

External Crossreferences and Linkouts ( 70 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38218

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W0A0

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9W0A0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W0A0

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027594

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38218/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0027594

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0027594

FlyMine - An integrated database for Drosophila genomics

FBgn0027594

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG2086

MARRVEL_MODEL - MARRVEL (model organism gene)

38218

Linkouts

BioGRID - A database of protein and genetic interactions.

63751

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0027594

DroID - A comprehensive database of gene and protein interactions.

FBgn0027594

DRSC - Results frm RNAi screens

FBgn0027594

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

drpr_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0027594

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0027594

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2086

Flygut - An atlas of the Drosophila adult midgut

FBgn0027594

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0027594

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC000689

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Efferocytosis

MIST (protein-protein) - An integrated Molecular Interaction Database

38218

References (304)

The following external sites may use different assemblies or annotations than FlyBase.

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