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General Information
Symbol
Dmel\drprI.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0258200
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-drpr-I, UAS-Draper-I, UAS-drpr
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of isoform I of drpr. Isoform I of drpr encodes an immunoreceptor tyrosine-based activation motif (ITAM) (corresponding to GH24127).

UASt regulatory sequences drive expression of drpr isoform I full length cDNA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of drprI.Scer\UAS under the control of Scer\GAL4GR1 in otherwise wild type and well-fed flies induces nurse cell death. Nurse cells condense and fragment in stage 8 and 9 egg chambers, but instead of engulfing nurse cells, the follicle cells initially thin out. Engulfment of the nurse cell debris eventually begins and proceeds normally.

Glial expression of drprI.Scer\UAS (under the control of Scer\GAL4repo) does not affect glial engulfment of axonal debris.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
NOT Suppressor of
Statement
Reference
Other
Statement
Reference
Phenotype Manifest In
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Expression of drprI.Scer\UAS under the control of Scer\GAL4repo.PU does not rescue the glial phagocytosis defects seen in repo03702 mutant embryos; the morphology and localisation of the glia still appear abnormal, and there is an increase in apoptotic particles outside of the glial cells.

Co-expression of NimC4Scer\UAS.T:Avic\GFP and drprI.Scer\UAS under the control of Scer\GAL4repo.PU fully rescues the phagocytosis defects seen in repo03702 mutant embryos.

Overexpression of drprI.Scer\UAS (under the control of Scer\GAL4repo) in a EcRB1-ΔC655.W650A.Scer\UAS background fails to transform astrocytes into phagocytes at puparium formation.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of drprI.Scer\UAS in the follicle cells under the control of Scer\GAL4GR1 rescues the enlargement and nurse cell debris uptake defects seen in starvation-induced degenerating egg chambers in drprΔ5 mutant flies. Unlike in drprΔ5 alone, no premature follicle cell death is seen.

Glial expression of drprI.Scer\UAS rescues the engulfment defects found in degenerating ORN axons in drprΔ5 mutants.

Expression of drprI.Scer\UAS under the control of Scer\GAL4fkh.PH in drprΔ5 mutant animals restores salivary gland degradation, and only 10% of animals display persistent gland material.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
drprI.Scer\UAS
drprI.UAS
Name Synonyms
Secondary FlyBase IDs
    References (13)