FlyBase Allele Report: Dmel\Rel[GD1199]

General Information

Symbol

Dmel\Rel^GD1199

Species

D. melanogaster

Name

FlyBase ID

FBal0208254

Feature type

allele

Associated gene

Dmel\Rel

Associated Insertion(s)

Carried in Construct

P{GD1199}

Also Known As

UAS-Rel^RNAi, UAS-Relish RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1199}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1199

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurodegenerative disease

modeled by drpr^Δ5

(Elguero et al., 2023)

ameliorates adult T-cell leukemia/lymphoma

modeled by HTLV-1\Tax^UAS.Tag:MYC

(Akkouche et al., 2021, Shirinian et al., 2015)

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{polyQ78.QUAS.Tag:HA}

(Li et al., 2018)

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Han et al., 2020)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.QUAS.Tag:SS(nec)}

(Li et al., 2018)

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^30.UAS.EGFP

(Han et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of Rel^GD1199 under the control of Scer\GAL4^Tk.PS leads to fewer enteroendocrine cells and more lipid droplets in the adult anterior midgut.

Adults show increased lethality to infection with V. cholerae.

(Jugder et al., 2021)

Expression of Rel^GD1199 under the control of Scer\GAL4^da.G32 leads to a modest but significant decrease in climbing ability (negative geotaxis) in older (20 days old) flies, but not in young (2 days old) flies, as compared to controls.

(Lee et al., 2020)

Expressing Rel^GD1199 under the control of either Scer\GAL4^Cg.PA or Scer\GAL4^ppl.PP (but not Scer\GAL4^Hml.Δ) results in a significantly reduced resistance to starvation and decreased lipid storage in the fat body of starved adult flies.

(Molaei et al., 2019)

Adults expressing Rel^GD1199 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) show significantly reduced avoidance of noxious temperature (46[o]C) compared to control flies.

Adults expressing Rel^GD1199 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) show no significant change in the kinetics of high temperature (46[o]C) induced paralysis compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Rel^GD1199, Scer\GAL4^{Tet-MI05009-GAL4} is a non-enhancer of increased cell number | larval stage phenotype of Mmus\Tet2^{R1261C.UAS.Tag:FLAG}, Scer\GAL4^{Tet-MI05009-GAL4}

(Ismail et al., 2023)

Rel^GD1199/Scer\GAL4^da.G32 is a non-enhancer of abnormal locomotor behavior | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Rel^GD1199/Scer\GAL4^da.G32 is a non-enhancer of abnormal locomotor behavior | adult stage phenotype of park²⁵

(Lee et al., 2020)

Suppressor of

Statement

Reference

Rel^GD1199, Scer\GAL4^GMR.PFa is a suppressor | partially of visible phenotype of HTLV-1\Tax^UAS.Tag:MYC, Scer\GAL4^GMR.PFa

(Shirinian et al., 2015)

NOT Suppressor of

Statement

Reference

Rel^GD1199, Scer\GAL4^{Tet-MI05009-GAL4} is a non-suppressor of increased cell number | larval stage phenotype of Mmus\Tet2^{R1261C.UAS.Tag:FLAG}, Scer\GAL4^{Tet-MI05009-GAL4}

(Ismail et al., 2023)

Rel^GD1199/Scer\GAL4^da.G32 is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Rel^GD1199/Scer\GAL4^da.G32 is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of park²⁵

(Lee et al., 2020)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Rel^GD1199, Scer\GAL4^{Tet-MI05009-GAL4} is a non-enhancer of embryonic/larval hemocyte | larval stage | increased number phenotype of Mmus\Tet2^{R1261C.UAS.Tag:FLAG}, Scer\GAL4^{Tet-MI05009-GAL4}

(Ismail et al., 2023)

Rel^GD1199/Scer\GAL4^da.G32 is a non-enhancer of flight muscle cell phenotype of Pink1^B9

(Lee et al., 2020)

Rel^GD1199/Scer\GAL4^da.G32 is a non-enhancer of mitochondrion | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Rel^GD1199/Scer\GAL4^da.G32 is a non-enhancer of flight muscle cell phenotype of park²⁵

(Lee et al., 2020)

Rel^GD1199/Scer\GAL4^da.G32 is a non-enhancer of mitochondrion | adult stage phenotype of park²⁵

(Lee et al., 2020)

Suppressor of

Statement

Reference

Rel^GD1199, Scer\GAL4^GMR.PFa is a suppressor | partially of eye phenotype of HTLV-1\Tax^UAS.Tag:MYC, Scer\GAL4^GMR.PFa

(Shirinian et al., 2015)

NOT Suppressor of

Statement

Reference

Rel^GD1199, Scer\GAL4^{Tet-MI05009-GAL4} is a non-suppressor of embryonic/larval hemocyte | increased number | larval stage phenotype of Mmus\Tet2^{R1261C.UAS.Tag:FLAG}, Scer\GAL4^{Tet-MI05009-GAL4}

(Ismail et al., 2023)

Rel^GD1199/Scer\GAL4^da.G32 is a non-suppressor of flight muscle cell phenotype of Pink1^B9

(Lee et al., 2020)

Rel^GD1199/Scer\GAL4^da.G32 is a non-suppressor of mitochondrion | adult stage phenotype of Pink1^B9

(Lee et al., 2020)

Rel^GD1199/Scer\GAL4^da.G32 is a non-suppressor of flight muscle cell phenotype of park²⁵

(Lee et al., 2020)

Rel^GD1199/Scer\GAL4^da.G32 is a non-suppressor of mitochondrion | adult stage phenotype of park²⁵

(Lee et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Rel^GD1199 under the control of Scer\GAL4^da.G32 does not modify the impaired climbing ability, or the disrupted tissue or mitochondrial integrity in the flight muscles phenotype of either young park²⁵ or young Pink1^B9 mutants.

(Lee et al., 2020)

Xenogenetic Interactions

Statement

Reference

Co-expression of Rel^GD1199 significantly reduces the rough-eye phenotype induced by Scer\GAL4^GMR.PFa>Zzzz\Tax-1^{Scer\UAS.T:Hsap\MYC}.

(Shirinian et al., 2015)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v49414

P{GD1199}v49414

v49413

w¹¹¹⁸; P{GD1199}v49413

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Rel^GD1199

Rel^RNAi

(Jugder et al., 2021)

Reli^GD

(Lee et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (21)

Report Sections

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