BG:DS00180.10 , P1, nimrod
Gene model reviewed during 5.42
Gene model reviewed during 5.52
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\NimC1 using the Feature Mapper tool.
nimC1 protein is expressed circulating plasmatocytes at all larval stages. nimC1 is additionally expressed in larval lymph glands, sessile and circulating hemocytes, and mitotically active hemocytes. Hemocytes expressing nimC1 phagocytose bacteria and produce antimicrobial peptides. nimC1 is not expressed in embryonic hemocytes, or in cells with lamellocyte morphology.
GBrowse - Visual display of RNA-Seq signalsView Dmel\NimC1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
S2 cells transfected with dsRNA made from templates generated with primers directed against this gene show normal levels of phagocytosis of bacteria.
Silencing of nimrod by dsRNS-mediated interference resulted in a reduction of phagocytosis of FITC labeled Staphylococcus aureus bacteria. Ectopic expression of nimrod in negative cell lines resulted in a dramatic increase of phagocytosis of both FITC labeled Staphylococcus aureus and E. coli bacteria.
The "nimrod" gene cluster is dubbed after Nimrod, the biblical "mighty hunter before the Lord" (Genesis 10), who according to Gesta Hungarorum was also the ancestor of all Hungarians (Kezai Simon, Gesta Hunnorum et Hungarorum A.D. 1282).