FlyBase Gene Report: Dmel\NimC2

General Information

Symbol

Dmel\NimC2

Species

D. melanogaster

Name

Nimrod C2

Annotation Symbol

CG18146

Feature Type

protein_coding_gene

FlyBase ID

FBgn0028939

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

BG:DS00180.14

Key Links

Genomic Location

Cytogenetic map

34E5-34E5

Sequence location

2L:13,980,126..13,983,269 [+]

Recombination map

2-50

RefSeq locus

NT_033779 REGION:13980126..13983269

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in immune response

inferred from biological aspect of ancestor with PANTHER:PTN001171370

(GO Reference Genome Project, 2011-)

involved_in phagocytosis

inferred from biological aspect of ancestor with PANTHER:PTN001171370

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with FLYBASE:NimC1; FB:FBgn0259896

(Kurucz et al., 2007)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from sequence model

(Kurucz et al., 2007)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN004653852

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

NIMROD-TYPE RECEPTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

NIMROD-TYPE RECEPTORS -: The Nimrod family of genes is characterised by the presence of NIM repeats, closely related to the EGF-repeat. They encode proteins which are secreted or integral to the plasma membrane. The Nimrod genes have been linked to the innate immune response and some members of this family have been shown to act as receptors for bacterial or apoptic cell phagocytosis. (Adapted from FBrf0212245).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\NimC2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q86BL2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.42

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

NimC2-RA

FBtr0080588

NM_135851

2343

648

NimC2-RB

FBtr0080589

NM_176033

2502

701

NimC2-RC

FBtr0343689

NM_001298993

2819

701

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

NimC2-PA

FBpp0080165

69.5

648

6.20

FBpp0080166

75.4

701

6.35

FBpp0310277

75.4

701

6.35

Q86BL2

NP_001285922

AHN54436

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

701 aa isoforms: NimC2-PB, NimC2-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\NimC2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

NimC2_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.29

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\NimC2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\NimC2

View exonic expression by tissue for Dmel\NimC2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34818/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0028939

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028939

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0028939

Flygut - An atlas of the Drosophila adult midgut

FBgn0028939

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of NimC2

Transgenic constructs containing regulatory region of NimC2

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (35)

Hsap\MEGF10

2 of 14

Yes

Hsap\MEGF11

2 of 14

Yes

Hsap\PEAR1

2 of 14

Yes

Hsap\SCARF1

2 of 14

Yes

Hsap\STAB1

2 of 14

Yes

Hsap\STAB2

2 of 14

Yes

Hsap\CCBE1

1 of 14

Hsap\DKK1

1 of 14

Yes

Hsap\DKK2

1 of 14

Yes

Hsap\DKK3

1 of 14

Yes

Hsap\DKK4

1 of 14

Yes

Hsap\DLL1

1 of 14

Hsap\ESM1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\WIF1

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (22)

Rnor\Megf10

2 of 14

Yes

Rnor\Dkk1

1 of 14

Yes

Rnor\Dkk2

1 of 14

Yes

Rnor\Dkk3

1 of 14

Yes

Rnor\Dkk4

1 of 14

Yes

Rnor\Dner

1 of 14

Rnor\Esm1

1 of 14

Yes

Rnor\Fbn1

1 of 14

Rnor\Fbn2

1 of 14

Rnor\Grn

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (29)

Mmus\Megf10

2 of 14

Yes

Mmus\Megf11

2 of 14

Yes

Mmus\Pear1

2 of 14

Yes

Mmus\Ccbe1

1 of 14

Mmus\Dkk1

1 of 14

Yes

Mmus\Dkk2

1 of 14

Yes

Mmus\Dkk3

1 of 14

Yes

Mmus\Dkk4

1 of 14

Yes

Mmus\Dner

1 of 14

Mmus\Egfem1

1 of 14

Mmus\Egfl6

1 of 14

Yes

Mmus\Esm1

1 of 14

Yes

Mmus\Fbn1

1 of 14

Mmus\Fbn2

1 of 14

Mmus\Grn

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (14)

Xtro\adgre2

1 of 13

Yes

Xtro\dlc

1 of 13

Yes

Xtro\egf

1 of 13

Yes

Xtro\fat1

1 of 13

Yes

Xtro\hmcn1

1 of 13

Yes

Xtro\jag1

1 of 13

Yes

Xtro\LOC101730707

1 of 13

Yes

Xtro\megf10

1 of 13

Yes

Xtro\mylk4

1 of 13

Yes

Xtro\nfxl1

1 of 13

Yes

Xtro\pear1

1 of 13

Yes

Xtro\tnn

1 of 13

Yes

Xtro\vwce

1 of 13

Yes

Xtro\znfx1

1 of 13

Yes

Danio rerio (Zebrafish) (28)

Drer\megf11

2 of 14

Yes

Drer\ccbe1

1 of 14

Drer\dkk1a

1 of 14

Yes

Drer\dkk1b

1 of 14

Yes

Drer\dkk2

1 of 14

Yes

Drer\dkk3b

1 of 14

Yes

Drer\egfl6

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (24)

Cele\F07H5.8

4 of 14

Yes

Cele\F35A5.4

3 of 14

Cele\pqn-13

2 of 14

Yes

Cele\C53B7.2

1 of 14

Yes

Cele\ced-1

1 of 14

Cele\cpg-24

1 of 14

Yes

Cele\D1044.7

1 of 14

Cele\dsl-1

1 of 14

Yes

Cele\dsl-2

1 of 14

Yes

Cele\dsl-5

1 of 14

Yes

Cele\dsl-6

1 of 14

Yes

Cele\dsl-7

1 of 14

Yes

Cele\F46B3.15

1 of 14

Yes

Cele\F47F2.3

1 of 14

Yes

Cele\F56B3.2

1 of 14

Cele\fbn-1

1 of 14

Cele\lag-2

1 of 14

Yes

Cele\M03F4.6

1 of 14

Cele\pqn-25

1 of 14

Cele\sdz-23

1 of 14

Yes

Cele\T01D3.1

1 of 14

Cele\ten-1

1 of 14

Cele\Y8A9A.2

1 of 14

Yes

Cele\Y64G10A.7

1 of 14

Anopheles gambiae (African malaria mosquito) (12)

Agam\AgaP_AGAP009763

4 of 12

Yes

Agam\AgaP_AGAP012386

4 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:NimC2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (21)

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

dpy

1 of 13

frac

1 of 13

shf

1 of 13

Ten-a

1 of 13

Ten-m

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

60847

DroID - A comprehensive database of gene and protein interactions.

FBgn0028939

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-50

Cytogenetic map

34E5-34E5

Sequence location

2L:13,980,126..13,983,269 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

34E5-34E5

Limits computationally determined from genome sequence between P{lacW}Sos^k05224&P{lacW}RpII33^k05605 and P{lacW}l(2)34Fa^k00811&P{PZ}wb⁰⁹⁴³⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-50

(FlyBase, 2016)

2-45.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

25960

y¹ v¹; P{TRiP.JF01980}attP2

NIG-Fly

18146R-6

P{NIG.18146R}6

M2L-1869

y¹ w¹¹¹⁸; NimC2^SK2 P{neoFRT}40A/CyO-Tb

M2L-1870

y¹ w¹¹¹⁸; NimC2^SK6 P{neoFRT}40A/CyO-Tb

2LG-1501

y² VhaAC39-1^cho-1 v¹; P{U6-NimC2.NIG.sgRNA}attP40/CyO

VDRC

v3120

w¹¹¹⁸; P{GD2622}v3120

v36261

w¹¹¹⁸; P{GD14387}v36261

v342130

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01628}attP40/CyO-GFP

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (5)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

IP13337

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0028939

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0028939

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

S2 cells transfected with dsRNA made from templates generated with primers directed against this gene show normal levels of phagocytosis of bacteria.

(Kocks et al., 2005)

Relationship to Other Genes

Source for database merge of

Source for merge of: BG:DS00180.14 CG18146

(Bayraktaroglu, 2000.4.12)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: nimC2 CG18146

(Kurucz et al., 2007)

Source for identity of: NimC2 nimC2

(FlyBase, 2009-)

Nomenclature comments

Etymology

The "nimrod" gene cluster is dubbed after Nimrod, the biblical "mighty hunter before the Lord" (Genesis 10), who according to Gesta Hungarorum was also the ancestor of all Hungarians (Kezai Simon, Gesta Hunnorum et Hungarorum A.D. 1282).

(Kurucz et al., 2007)

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

BG:DS00180.14

(Giot et al., 2003, Parra et al., 2000, Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12)

CG18146

(National Institute of Genetics Fly Stocks, 2022-, Okuda et al., 2016, Palu and Thummel, 2016, Japanese National Institute of Genetics, 2012.5.21, Perkins et al., 2009.1.15, Bhutkar et al., 2008, Inomata et al., 2008, Weake et al., 2008, Ulvila et al., 2006, Kocks et al., 2005)

CG18146-PB

(Kurucz et al., 2007)

CT40902

(Hynes and Zhao, 2000)

DS00180.14

(Reese et al., 2000)

NimC2

(Salminen et al., 2024, Chen et al., 2023, Deshpande et al., 2022, Gene Disruption Project members, 2018-, Somogyi et al., 2008, Kurucz et al., 2007)

nimC2

(Aw et al., 2017, Fernández-Ayala et al., 2010, Somogyi et al., 2010, Kurucz et al., 2007)

Name Synonyms

CG18146

Nimrod C2

nimrod C2

Secondary FlyBase IDs

FBgn0032541

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 34 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34818

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AE003408

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q86BL2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q86BL2

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34818/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0028939

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0028939

FlyMine - An integrated database for Drosophila genomics

FBgn0028939

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG18146

MARRVEL_MODEL - MARRVEL (model organism gene)

34818

Linkouts

BioGRID - A database of protein and genetic interactions.

60847

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0028939

DroID - A comprehensive database of gene and protein interactions.

FBgn0028939

DRSC - Results frm RNAi screens

FBgn0028939

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

NimC2_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028939

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0028939

Flygut - An atlas of the Drosophila adult midgut

FBgn0028939

References (44)

The following external sites may use different assemblies or annotations than FlyBase.

-0.29

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