FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\numb985
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General Information
Symbol
Dmel\numb985
Species
D. melanogaster
Name
FlyBase ID
FBal0197594
Feature type
allele
Associated gene
Dmel\numb
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Edenfeld et al., 2007)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In numb985 mutant embryos, glial migration is defective. In most hemisegments, the ventral peripheral glial and medial intersegmental peripheral glial cells fail to migrate dorsally to their wild-type destinations, but stay close to the nerve roots. However, in approximately 15% of cases these glial cells migrate too far and form a cluster close to the oenocytes. Furthermore, the dIPG is prevented from its ventral migration and stays close to where it originates.

      (Edenfeld et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      numb985
      (Edenfeld et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)