FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

epidermal growth factor receptor signaling pathway

ID (Ontology)

GO:0007173 (Gene Ontology)

Definition

The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.

Also Known As

"EGF receptor signaling pathway" ; "EGF receptor signalling pathway" ; "EGFR signaling pathway" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
epidermal growth factor receptor signaling pathway (all annotations which use CV term, excluding "NOT" statements)
involved_in \| epidermal growth factor receptor signaling pathway	--

Spanning Tree (Parents/Children)

  cell surface receptor protein tyrosine kinase signaling pathway
   |__ERBB signaling pathway
       |__epidermal growth factor receptor signaling pathway  85 rec.
           |__ERBB2-EGFR signaling pathway
           |__ERBB4-EGFR signaling pathway
           |__regulation of epidermal growth factor receptor signaling pathway 60 rec.
               |__negative regulation of epidermal growth factor receptor signaling pathway(+) 40 rec.
               |__positive regulation of epidermal growth factor receptor signaling pathway 19 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	ERBB signaling pathway
Part of
Synonyms & Secondary IDs
Synonyms
	"EGF receptor signaling pathway" EXACT "EGF receptor signalling pathway" EXACT "EGFR signaling pathway" EXACT "epidermal growth factor receptor signalling pathway" EXACT "ERBB1 signaling pathway" EXACT "receptor tyrosine-protein kinase erbB-1 signaling pathway" EXACT
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-177929 "Signaling by EGFR"