FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term epidermal growth factor receptor signaling pathway ID (Ontology) GO:0007173 (Gene Ontology)
Definition The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
Also Known As "EGF receptor signaling pathway" ; "EGF receptor signalling pathway" ; "EGFR signaling pathway" (for all, see Synonyms field below)
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      25
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 epidermal growth factor receptor signaling pathway (all annotations which use CV term, excluding "NOT" statements)       2     25
     involved_in | epidermal growth factor receptor signaling pathway       --      25
Spanning Tree (Parents/Children)
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  cell surface receptor protein tyrosine kinase signaling pathway
   |__ERBB signaling pathway
       |__epidermal growth factor receptor signaling pathway  85 rec.
           |__ERBB2-EGFR signaling pathway
           |__ERBB4-EGFR signaling pathway
           |__regulation of epidermal growth factor receptor signaling pathway 60 rec.
               |__negative regulation of epidermal growth factor receptor signaling pathway(+) 40 rec.
               |__positive regulation of epidermal growth factor receptor signaling pathway 19 rec.
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Is a ERBB signaling pathway
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Synonyms
  • "EGF receptor signaling pathway" EXACT
    "EGF receptor signalling pathway" EXACT
    "EGFR signaling pathway" EXACT
    "epidermal growth factor receptor signalling pathway" EXACT
    "ERBB1 signaling pathway" EXACT
    "receptor tyrosine-protein kinase erbB-1 signaling pathway" EXACT
Secondary IDs
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Reactome:R-HSA-177929 "Signaling by EGFR"