FlyBase Gene Report: Dmel\hwt

General Information

Symbol

Dmel\hwt

Species

D. melanogaster

Name

heavyweight

Annotation Symbol

CG43921

Feature Type

protein_coding_gene

FlyBase ID

FBgn0264542

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

lincRNA.981

Key Links

Genomic Location

Cytogenetic map

11A12-11B1

Sequence location

X:12,516,634..12,568,452 [-]

Recombination map

1-39

RefSeq locus

NC_004354 REGION:12516634..12568452

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (1 term)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables phosphotyrosine residue binding

inferred from biological aspect of ancestor with PANTHER:PTN001031645

(GO Reference Genome Project, 2011-)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\hwt for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry M9PEE4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.46

Unconventional translation start (AUC) postulated; FlyBase analysis.

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

hwt-RA

FBtr0333154

NM_001272555

9201

1768

hwt-RB

FBtr0333155

NM_167324

6878

1510

hwt-RC

FBtr0333156

NM_132578

6986

880

hwt-RD

FBtr0346131

NM_001298227

6221

1449

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

hwt-PA

FBpp0305357

189.7

1768

8.41

FBpp0305358

163.8

1510

6.95

FBpp0305359

93.8

880

6.87

FBpp0311960

156.9

1449

6.86

X2JDE5

NP_001285156

AHN59626

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\hwt using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.79

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\hwt in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\hwt

View exonic expression by tissue for Dmel\hwt

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264542

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32202/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264542

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264542

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32653

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of hwt

Transgenic constructs containing regulatory region of hwt

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(1)Exel6244

(Ryder, 2004.4.26)

Inferred from location ( 38 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

hwt^GD15014

Other Phenotypes

Allele

abnormal planar polarity, with Scer\GAL4^hs.2sev

hwt^GD15014

abnormal starvation stress response | :RU486 conditional | nutrition conditional

hwt^GD15014

short lived | :RU486 conditional | nutrition conditional, with Scer\GAL4^{Act5C.Switch.PR}

hwt^GD15014

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

hwt^GD15014

Phenotype manifest in

Allele

ommatidium, with Scer\GAL4^hs.2sev

hwt^GD15014

wing hair | increased number, with Scer\GAL4^en-e16E

hwt^GD15014

wing vein, with Scer\GAL4^en-e16E

hwt^GD15014

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (47)

Hsap\SHB

6 of 14

Yes

Hsap\SHD

6 of 14

Yes

Hsap\SHF

6 of 14

Yes

Hsap\SHE

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\SH2D7

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (36)

Rnor\Shb

6 of 14

Yes

Rnor\Shd

6 of 14

Yes

Rnor\She

6 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Socs1

1 of 14

Rnor\Socs2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (39)

Mmus\Shb

6 of 14

Yes

Mmus\Shd

6 of 14

Yes

Mmus\She

5 of 14

Yes

Mmus\Shf

4 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (38)

Xtro\shb

5 of 13

Yes

Xtro\shf

5 of 13

Yes

4 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\socs1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (45)

Drer\shda

7 of 14

Yes

Drer\shdb

6 of 14

Yes

Drer\she

4 of 14

Yes

Drer\zgc:158464

4 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\csk

1 of 14

Drer\hsh2d

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\sh2d4bb

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (12)

Cele\soem-1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (16)

Agam\AgaP_AGAP010886

8 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:hwt. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (16)

Abl

1 of 13

Cortactin

1 of 13

Csk

1 of 13

csw

1 of 13

dock

1 of 13

drk

1 of 13

Lnk

1 of 13

Pi3K21B

1 of 13

Shc

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

vap

1 of 13

Vav

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SHB; SH2 domain containing adaptor protein B

6 of 14

600314

SHD; Src homology 2 domain containing transforming protein D

6 of 14

610481

SHF; Src homology 2 domain containing F

6 of 14

617313

SHE; Src homology 2 domain containing E

5 of 14

610482

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

hwt

(Weber et al., 2012)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0264542

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q7KV33

Class of Gene

gene_with_non_canonical_start_codon

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-39

Cytogenetic map

11A12-11B1

Sequence location

X:12,516,634..12,568,452 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

11A12-11B1

Limits computationally determined from genome sequence between P{EP}EP1451&P{EP}EP1629 and P{EP}CG11138^EP1313

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-39

(FlyBase, 2016)

1-39.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

11373

11464

103875

y^* w^* P{GawB}hwt^NP1073 / FM7c

VDRC

v101324

P{KK107565}VIE-260B

v109557

P{KK115679}VIE-260B

Genomic Clones (41)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (3)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

New annotation (CG32653) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG11146 CG32653

(FlyBase Genome Annotators, 2008)

Source for merge of: CG32653 BcDNA:GH02424

(FlyBase, 1996-)

Source for merge of:

(FlyBase Genome Annotators, 2012)

Source for merge of: CG15729 CG4225

(FlyBase Genome Annotators, 2012)

Additional comments

Annotations CG15729 and CG42251 merged as CG43921 in release 5.46 of the genome annotation. Merge supported by RNA-seq junction data.

(FlyBase Genome Annotators, 2012)

Annotations CG11146 and CG32653 merged as CG42251 in release 5.8 of the genome annotation.

(FlyBase Genome Annotators, 2008)

Source for merge of CG32653 BcDNA:GH02424 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: hwt CG43921

(Nelson et al., 2016)

Nomenclature comments

Etymology

The gene is named 'heavyweight' due to effects on control of body mass.

(Nelson et al., 2016)

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

43921

(Golovnin et al., 2015)

BcDNA:GH02424

CG11146

(Hoi et al., 2016, Weber et al., 2012, Keleman et al., 2009.8.5, Weake and Scott, 2007)

CG15729

CG32653

(Weber et al., 2012, Keleman et al., 2009.8.5)

CG42251

(Horan et al., 2015, Smibert et al., 2012, Weber et al., 2012, FlyBase Genome Annotators, 2008)

CG43921

(Olson et al., 2019, Nelson et al., 2016, FlyBase Genome Annotators, 2012, Weber et al., 2012)

hwt

(Nelson et al., 2016)

lincRNA.981

(FlyBase Genome Annotators, 2014, Young et al., 2012)

Name Synonyms

CG11146

CG32653

heavyweight

(Nelson et al., 2016)

Secondary FlyBase IDs

FBgn0030399
FBgn0259109
FBgn0030397
FBgn0052653
FBgn0046808

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 47 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32202

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

M9PEE4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

M9PEE4

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264542

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32202/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264542

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264542

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG43921

MARRVEL_MODEL - MARRVEL (model organism gene)

32202

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0264542

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0264542

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32653

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q7KV33

References (38)

The following external sites may use different assemblies or annotations than FlyBase.

-0.79

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