FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Cortactin
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General Information
Symbol
Dmel\Cortactin
Species
D. melanogaster
Name
Cortactin
Annotation Symbol
CG3637
Feature Type
protein_coding_gene
FlyBase ID
FBgn0025865
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Summary
cytoskeletal component that acts as a link, via Src, between surface receptors and actin - interacts with F-actin and can stimulate actin polymerization by direct interaction with the Arp2/3 complex (Interactive Fly, Cortactin )
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

DCortactin

Key Links
Genomic Location
Cytogenetic map
93B8-93B9
Sequence location
Recombination map
3-70
RefSeq locus
NT_033777 REGION:21061680..21064471
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (17 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables proline-rich region binding
inferred from genetic interaction with FLYBASE:mim; FB:FBgn0053558
(Quinones et al., 2010)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables actin filament binding
inferred from biological aspect of ancestor with PANTHER:PTN000850943
(GO Reference Genome Project, 2011-)
Biological Process (7 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in border follicle cell migration
inferred from mutant phenotype
(Quinones et al., 2010, Somogyi and Rorth, 2004)
involved_in female germline ring canal formation
inferred from mutant phenotype
(Somogyi and Rorth, 2004)
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation
inferred from mutant phenotype
(O'Connell et al., 2019)
involved_in positive regulation of receptor-mediated endocytosis
inferred from genetic interaction with FLYBASE:mim; FB:FBgn0053558
(Quinones et al., 2010)
involved_in protein localization to actin cytoskeleton
inferred from mutant phenotype
(O'Connell et al., 2019)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in cell migration
inferred from biological aspect of ancestor with PANTHER:PTN008507007
(GO Reference Genome Project, 2011-)
involved_in regulation of actin filament polymerization
inferred from biological aspect of ancestor with PANTHER:PTN000850943
(GO Reference Genome Project, 2011-)
Cellular Component (8 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
located_in actin cap
inferred from direct assay
(Rikhy et al., 2015)
located_in lamellipodium
inferred from direct assay
(O'Connell et al., 2019)
located_in plasma membrane
inferred from direct assay
(Rikhy et al., 2015)
part_of protein-containing complex
inferred from physical interaction with FLYBASE:mim; FB:FBgn0053558
(Quinones et al., 2010)
located_in sperm individualization complex
inferred from direct assay
(Rogat and Miller, 2002)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
colocalizes_with actin filament
inferred from biological aspect of ancestor with PANTHER:PTN000850943
(GO Reference Genome Project, 2011-)
is_active_in cortical actin cytoskeleton
inferred from biological aspect of ancestor with PANTHER:PTN000850943
(GO Reference Genome Project, 2011-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN008507007
(GO Reference Genome Project, 2011-)
is_active_in site of polarized growth
inferred from biological aspect of ancestor with PANTHER:PTN000089187
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Summary (Interactive Fly)

cytoskeletal component that acts as a link, via Src, between surface receptors and actin - interacts with F-actin and can stimulate actin polymerization by direct interaction with the Arp2/3 complex

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Cortactin for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VDF4)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.39

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cortactin-RA
FBtr0084039
NM_079702
2416
559
Cortactin-RB
FBtr0306347
NM_001260293
2419
559
Cortactin-RC
FBtr0306348
NM_001260294
2391
559
Cortactin-RD
FBtr0306349
NM_001260295
2388
559
Additional Transcript Data and Comments
Reported size (kB)

2.7 (northern blot)

(Katsube et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Cortactin-PA
FBpp0083441
61.1
559
4.82
Q9VDF4
NP_524426
AAF55840
Cortactin-PB
FBpp0297440
61.1
559
4.82
Q9VDF4
NP_001247222
AFH06540
Cortactin-PC
FBpp0297441
61.1
559
4.82
Q9VDF4
NP_001247223
AFH06541
Cortactin-PD
FBpp0297442
61.1
559
4.82
Q9VDF4
NP_001247224
AFH06542
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

559 aa isoforms: Cortactin-PA, Cortactin-PB, Cortactin-PC, Cortactin-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

559 (aa); 61 (kD predicted)

(Katsube et al., 1998)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cortactin using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.10

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
Malpighian tubule primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic Malpighian tubule
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval plasmatocyte
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Katsube et al., 1998)
Additional Descriptive Data

An anti-Cortactin protein antibody recognizes proteins of 105 and 110 kD in all developmental stages, with high levels in embryos, larvae, and pupae, and low levels in adults. The size observed on SDS-PAGE (105 and 110 kD) is much larger than the predicted size (61 kD); a similar disparity has been observed for vertebrate Cortactin, and may be due to the proline-rich domains.

(Katsube et al., 1998)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in actin cap
inferred from direct assay
(Rikhy et al., 2015)
located_in lamellipodium
inferred from direct assay
(O'Connell et al., 2019)
located_in plasma membrane
inferred from direct assay
(Rikhy et al., 2015)
part_of protein-containing complex
inferred from physical interaction with FLYBASE:mim; FB:FBgn0053558
(Quinones et al., 2010)
located_in sperm individualization complex
inferred from direct assay
(Rogat and Miller, 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cortactin in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 14 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cortactin
Transgenic constructs containing regulatory region of Cortactin
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3R)Exel6272
(Ryder, 2004.4.26)
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (39)
Hsap\CTTN
13 of 14
Yes
Yes
1  
Hsap\HCLS1
9 of 14
No
Yes
Hsap\ABI1
1 of 14
No
No
Hsap\ABI2
1 of 14
No
No
Hsap\ABI3
1 of 14
No
No
Hsap\ABL1
1 of 14
No
No
0  
Hsap\ABL2
1 of 14
No
No
2  
Hsap\BLK
1 of 14
No
No
Hsap\BTK
1 of 14
No
No
3  
Hsap\CSK
1 of 14
No
No
1  
Hsap\DBN1
1 of 14
No
No
Hsap\DBNL
1 of 14
No
No
Hsap\FGR
1 of 14
No
No
1  
Hsap\FRK
1 of 14
No
No
Hsap\FYN
1 of 14
No
No
3  
Hsap\GRAP2
1 of 14
No
No
Hsap\GRAP
1 of 14
No
No
2  
Hsap\GRB2
1 of 14
No
No
Hsap\HCK
1 of 14
No
No
Hsap\ITK
1 of 14
No
No
1  
Hsap\ITSN1
1 of 14
No
No
Hsap\LCK
1 of 14
No
No
Hsap\LYN
1 of 14
No
No
Hsap\MATK
1 of 14
No
No
1  
Hsap\MYO1E
1 of 14
No
No
Hsap\NCK1
1 of 14
No
No
2  
Hsap\NCK2
1 of 14
No
No
Hsap\PACSIN1
1 of 14
No
No
2  
Hsap\PTK6
1 of 14
No
No
Hsap\RASA1
1 of 14
No
No
Hsap\SH2D7
1 of 14
No
Yes
Hsap\SLA2
1 of 14
No
No
Hsap\SLA
1 of 14
No
Yes
Hsap\SRC
1 of 14
No
No
Hsap\SRMS
1 of 14
No
No
Hsap\TXK
1 of 14
No
No
Hsap\VAV1
1 of 14
No
No
1  
Hsap\VAV2
1 of 14
No
No
Hsap\YES1
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (8)
Rnor\Cttn
12 of 14
Yes
Yes
Rnor\Hcls1
9 of 14
No
Yes
Rnor\Abi1
1 of 14
No
No
Rnor\Abi2
1 of 14
No
No
Rnor\Abi3
1 of 14
No
No
Rnor\Dbn1
1 of 14
No
No
Rnor\Dbnl
1 of 14
No
No
Rnor\Itsn1
1 of 14
No
No
Mus musculus (laboratory mouse) (8)
Mmus\Cttn
11 of 14
Yes
Yes
Mmus\Hcls1
9 of 14
No
Yes
Mmus\Abi1
1 of 14
No
No
Mmus\Abi2
1 of 14
No
No
Mmus\Abi3
1 of 14
No
No
Mmus\Dbn1
1 of 14
No
No
Mmus\Dbnl
1 of 14
No
No
Mmus\Itsn1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (24)
Xtro\hcls1
9 of 13
Yes
Yes
Xtro\cttn
8 of 13
No
Yes
Xtro\abi3
1 of 13
No
No
Xtro\abl1
1 of 13
No
No
Xtro\abl2
1 of 13
No
No
Xtro\asap1
1 of 13
No
No
Xtro\bcar3
1 of 13
No
No
Xtro\btk
1 of 13
No
No
Xtro\csk
1 of 13
No
No
Xtro\frk
1 of 13
No
No
Xtro\grap
1 of 13
No
No
Xtro\grb2
1 of 13
No
No
Xtro\hsh2d
1 of 13
No
Yes
Xtro\itsn2
1 of 13
No
No
Xtro\lck
1 of 13
No
No
Xtro\LOC100490678
1 of 13
No
No
Xtro\lrit2
1 of 13
No
No
Xtro\nck1
1 of 13
No
No
Xtro\ptk6
1 of 13
No
No
Xtro\rasa1
1 of 13
No
No
Xtro\sla2
1 of 13
No
Yes
Xtro\sla
1 of 13
No
Yes
Xtro\tepsin
1 of 13
No
No
Xtro\uqcrfs1
1 of 13
No
No
Danio rerio (Zebrafish) (14)
Drer\cttn
11 of 14
Yes
Yes
Drer\hcls1
10 of 14
No
Yes
Drer\si:dkey-40c11.2
2 of 14
No
No
Drer\abi1a
1 of 14
No
No
Drer\abi1b
1 of 14
No
No
Drer\abi2a
1 of 14
No
No
Drer\abi2b
1 of 14
No
No
Drer\abi3a
1 of 14
No
No
Drer\abi3b
1 of 14
No
No
Drer\asap1b
1 of 14
No
No
Drer\dbn1
1 of 14
No
No
Drer\dbnla
1 of 14
No
No
Drer\dbnlb
1 of 14
No
No
Drer\myo1ea
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\abi-1
1 of 14
Yes
No
Cele\abl-1
1 of 14
Yes
No
Cele\dbn-1
1 of 14
Yes
No
Cele\nck-1
1 of 14
Yes
No
Cele\sem-5
1 of 14
Yes
No
Cele\src-1
1 of 14
Yes
No
Cele\src-2
1 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (10)
Agam\AgaP_AGAP004625
11 of 12
Yes
Yes
Agam\AgaP_AGAP001046
1 of 12
No
No
Agam\AgaP_AGAP002710
1 of 12
No
No
Agam\AgaP_AGAP002729
1 of 12
No
No
Agam\AgaP_AGAP004989
1 of 12
No
No
Agam\AgaP_AGAP006270
1 of 12
No
No
Agam\AgaP_AGAP006510
1 of 12
No
No
Agam\AgaP_AGAP007717
1 of 12
No
No
Agam\AgaP_AGAP011768
1 of 12
No
No
Agam\AgaP_AGAP012240
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\ABP1
3 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\abp1
2 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Cortactin. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (13)
Abp1
5 of 13
CG6891
2 of 13
Abi
1 of 13
Abl
1 of 13
Btk
1 of 13
dpy
1 of 13
drk
1 of 13
hwt
1 of 13
sl
1 of 13
spri
1 of 13
Src42A
1 of 13
Src64B
1 of 13
vap
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 3 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CTTN; cortactin
    13 of 14
    164765
         
        HCLS1; hematopoietic cell-specific Lyn substrate 1
        9 of 14
        601306
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Summary of Genetic Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Cortactin
            suppressible
            mim
            (Quinones et al., 2010)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            mim
            suppressible
            Cortactin
            (Quinones et al., 2010)
            Pvr
            suppressible
            Cortactin
            (Somogyi and Rorth, 2004)
            Src42A
            suppressible
            Cortactin
            (Somogyi and Rorth, 2004)
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            External Data
            Linkouts
            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map
            3-70
            Cytogenetic map
            93B8-93B9
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            93B8-93B9
            Limits computationally determined from genome sequence between P{PZ}Atpα01164 and P{PZ}mod(mdg4)07038&P{lacW}mod(mdg4)L3101
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            93B-93B
            (determined by in situ hybridisation)
            (Katsube et al., 2001)
            93B3-93B7
            (Katsube, 1999.7.16)
            93B3-93B6
            (Katsube, 1997.12.26)
            Experimentally Determined Recombination Data
            Location

            3-70

            (FlyBase, 2016)

            3-73.4

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (14)
            Genomic Clones (17)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (140)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Katsube et al., 1998)
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments

                Cortactin modulates cell migration and ring canal morphogenesis during oogenesis.

                (Somogyi and Rorth, 2004)

                dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                (Kiger et al., 2003)

                RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become retracted (unspread but flat). Kc167 cells are unaffected.

                (Kiger et al., 2003)

                dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

                (Rogers et al., 2003)
                Relationship to Other Genes
                Source for database merge of
                Additional comments
                Nomenclature History
                Source for database identify of

                Source for identity of: Cortactin CG3637

                (Gong, 1999.11)
                Nomenclature comments
                Etymology
                Synonyms and Secondary IDs (5)
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
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                Study result (0)
                Result
                Result Type
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                External Crossreferences and Linkouts ( 54 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                FlyMine - An integrated database for Drosophila genomics
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                MIST (protein-protein) - An integrated Molecular Interaction Database
                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                References (85)