FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CortactinD4
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General Information
Symbol
Dmel\CortactinD4
Species
D. melanogaster
Name
FlyBase ID
FBal0156776
Feature type
allele
Associated gene
Dmel\Cortactin
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Somogyi and Rorth, 2004)
Progenitor genotype
P{EPg}CortactinEPg35301
(Somogyi and Rorth, 2004)
Cytology
Description

Imprecise excision has created a 2070 deletion downstream of the insertion site of P{EPg}CortactinEPg35301 to the middle of the fourth exon of the Cortactin gene.

(Somogyi and Rorth, 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous mutants show no visible abnormalities. When mutant ovaries are examined, they exhibit a mild defect in 'dumping' - the transfer of bulk cytoplasmic material from nurse cells to the oocyte. The size of ring canals is seriously reduced in mutant ovaries. Eggs laid by mutant mothers were on average smaller than wild-type. The hatching rate of eggs from mutant mothers is also decreased. With low penetrance (about 6% of stages 5-9 egg chambers) mutants also display discontinuities in the follicular epithelium.

      (Somogyi and Rorth, 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CortactinD4
      cortD4
      (Johnson et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)