FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pi3K21Bunspecified
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General Information
Symbol
Dmel\Pi3K21Bunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0120692
Feature type
allele
Associated gene
Dmel\Pi3K21B
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        ameliorates  cancer
        modeled by Nek2UAS.GFP, RetMEN2B.UAS
        (Das et al., 2013)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mosaic flies in which the head is mutant for Pi3K92Eunspecified (clones generated using the "eyFLP" system) have smaller eyes than controls.

        (Oldham et al., 2002)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressed by
        Statement
        Reference

        Pi3K21Bunspecified has decreased body size | somatic clone phenotype, suppressible by Pten117/Pten117

        (Oldham et al., 2002)
        NOT Enhancer of
        Statement
        Reference

        Pi3K21Bunspecified/Pi3K21B[+] is a non-enhancer of visible phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

        (Coelho et al., 2005)
        NOT Suppressor of
        Statement
        Reference

        Pi3K21Bunspecified/Pi3K21B[+] is a non-suppressor of visible phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

        (Coelho et al., 2005)
        Other
        Phenotype Manifest In
        NOT Enhancer of
        Statement
        Reference

        Pi3K21Bunspecified/Pi3K21B[+] is a non-enhancer of wing phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

        (Coelho et al., 2005)
        NOT Suppressor of
        Statement
        Reference

        Pi3K21Bunspecified/Pi3K21B[+] is a non-suppressor of wing phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

        (Coelho et al., 2005)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Expression of RetMEN2B.Scer\UAS enhances the "distant seeding" phenotype seen when Nek2Scer\UAS.T:Avic\GFP is expressed under the control of Scer\GAL4GMR.PF. Larger groups of Avic\GFP-positive cells are detected in distant body parts. This phenotype is significantly reduced when flies also carry one copy each of Pi3K21Bunspecified and S6kunspecified. The phenotype can also be suppressed by drugs that inhibit signalling along the PI3K cascade; LY294002, Rapamycin, MK2206 or BEZ235.

        (Das et al., 2013)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Pi3K21Bunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (5)