FlyBase Allele Report: Dmel\Pten[2L100]

General Information

Symbol

Dmel\Pten^2L100

Species

D. melanogaster

Name

FlyBase ID

FBal0144651

Feature type

allele

Associated gene

Dmel\Pten

Associated Insertion(s)

Carried in Construct

Also Known As

PTEN¹⁰⁰

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Oldham et al., 2002)

Mutagen

Progenitor genotype

Cytology

Description

Mutation outside of the open reading frame.

(Oldham et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA with Pten¹¹⁷

(Ganguly et al., 2021)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal stress response (with Pten¹¹⁷)

(Oldham et al., 2002)

increased body size (with Pten¹¹⁷)

(Oldham et al., 2002)

increased body size | adult stage (with Pten¹¹⁷)

(Nowak et al., 2013)

increased body size | larval stage (with Pten¹¹⁷)

(Nowak et al., 2013)

increased body size | larval stage | nutrition conditional (with Pten¹¹⁷)

(Nowak et al., 2013)

increased body size | pupal stage (with Pten¹¹⁷)

(Ganguly et al., 2021)

increased body weight | adult stage (with Pten¹¹⁷)

(Ganguly et al., 2021)

increased cell number (with Pten¹¹⁷)

(Oldham et al., 2002)

increased cell size (with Pten¹¹⁷)

(Oldham et al., 2002)

lethal - all die before end of larval stage | nutrition conditional (with Pten¹¹⁷)

(Nowak et al., 2013)

viable

(Wittwer et al., 2005, Oldham et al., 2002)

Phenotype Manifest In

imaginal disc | nutrition conditional (with Pten¹¹⁷)

(Nowak et al., 2013)

interommatidial cell | P-stage

(Malin et al., 2024)

interommatidial cell | somatic clone

(Malin et al., 2024)

ommatidium | P-stage

(Malin et al., 2024)

ommatidium | somatic clone

(Malin et al., 2024)

tertiary pigment cell | P-stage

(Malin et al., 2024)

Detailed Description

Statement

Reference

Pten¹¹⁷/Pten^2L100 mutant larvae and adult flies are larger than wild-type controls under normal food conditions. The prospective adult tissues, the eye and wing imaginal discs are larger than in controls. These larvae are highly sensitive to a reduction in yeast content, and although still larger, they do not survive to pupariation when reared on 10g/l yeast food. Pten¹¹⁷/Pten^2L100 mutant larvae reared on 100g/l yeast food at 39% larger than controls reared on 100g\l yeast food.

(Nowak et al., 2013)

Weak temperature sensitive mutation. Pten^2L100/Pten¹¹⁷ larvae, pupae and adults are substantially increased in size compared to control larvae. Pten^2L100/Pten¹¹⁷ adults are hypersensitive to starvation conditions compared to wild type.

(Oldham et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Pten^2L100/Pten¹¹⁷ has increased body size | pupal stage phenotype, suppressible by Scer\GAL4^da.PU/Hsap\PTEN^UAS.cPa

(Ganguly et al., 2021)

Pten^2L100/Pten¹¹⁷ has increased body weight | adult stage phenotype, suppressible by Scer\GAL4^da.PU/Hsap\PTEN^UAS.cPa

(Ganguly et al., 2021)

Suppressor of

Statement

Reference

Pten^2L100/Pten¹¹⁷ is a suppressor | partially of lethal | larval stage phenotype of InR^93Dj-4/InR³⁰⁴

(Oldham et al., 2002)

Pten^2L100/Pten¹¹⁷ is a suppressor | partially of lethal | larval stage phenotype of InR³²⁷/InR³⁰⁴

(Oldham et al., 2002)

NOT Suppressor of

Statement

Reference

Pten^2L100/Pten¹¹⁷ is a non-suppressor of lethal phenotype of Pi3K92E^unspecified

(Oldham et al., 2002)

Other

Statement

Reference

B4^unspecified, Pten^2L100 has lethal phenotype

(Wittwer et al., 2005)

Pi3K21B^unspecified, Pten^2L100/Pten¹¹⁷ has viable phenotype

(Oldham et al., 2002)

InR³²⁷/InR³⁰⁴, Pten^2L100/Pten¹¹⁷ has lethal | pupal stage phenotype

(Oldham et al., 2002)

InR^93Dj-4/InR³⁰⁴, Pten^2L100/Pten¹¹⁷ has lethal | pupal stage phenotype

(Oldham et al., 2002)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

PTEN¹⁰⁰

(Portela et al., 2010)

PTEN^100A

(Nowak et al., 2013)

PTEN^2L100

(Reiling and Hafen, 2004)

Pten¹⁰⁰

(Ganguly et al., 2021, Tokusumi et al., 2012)

Pten^2L100

(Tokusumi et al., 2012, Rhiner et al., 2009, Wittwer et al., 2005)

pten^2L100

(Malin et al., 2024)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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