FB2026_02 , released June 18, 2026

CV Term Report

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General Information

Term

phosphatidylinositol 3-kinase/protein kinase B signal transduction

ID (Ontology)

GO:0043491 (Gene Ontology)

Definition

An intracellular signaling cassette that starts with phosphatidylinositol 3-kinase (PI3K) activation, production of phosphatidylinositol 3-phosphate (PI3P), activation of PDK1, which recruits and ending with the activation of protein kinase B (PKB, also known as Akt). PI3K is activated by cell surface receptors. Note that PTEN is an inhibitor of the pathway.[ PubMed:20517722 PubMed:22952397 ]

Also Known As

"phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction" ; "PI3K-PKB/Akt pathway" ; "PI3K/Akt signal transduction" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
phosphatidylinositol 3-kinase/protein kinase B signal transduction (all annotations which use CV term, excluding "NOT" statements)
involved_in \| phosphatidylinositol 3-kinase/protein kinase B signal transduction

Spanning Tree (Parents/Children)

  intracellular signal transduction
   |__intracellular signaling cassette
       |__phosphatidylinositol 3-kinase/protein kinase B signal transduction  32 rec.
           |__regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 27 rec.
               |__negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 10 rec.
               |__positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 17 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	intracellular signaling cassette
Part of
Synonyms & Secondary IDs
Synonyms
	"AKT signal transduction" RELATED "AKT signaling" RELATED "AKT signaling cascade" RELATED "AKT signalling cascade" RELATED "phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction" EXACT "PI3K-PKB/Akt pathway" EXACT "PI3K/Akt signal transduction" EXACT "PI3K/PKB signal transduction" EXACT "PKB signal transduction" RELATED "PKB signaling" RELATED "PKB signaling cascade" RELATED "PKB signalling cascade" RELATED "protein kinase B signal transduction" RELATED "protein kinase B signaling" RELATED "protein kinase B signaling cascade" RELATED "protein kinase B signalling cascade" RELATED
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-198203 "PI3K/AKT activation" Reactome:R-HSA-198323 "AKT phosphorylates targets in the cytosol" Reactome:R-HSA-198693 "AKT phosphorylates targets in the nucleus"