FlyBase Allele Report: Dmel\drk[10626]

General Information

Symbol

Dmel\drk¹⁰⁶²⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0003116

Feature type

allele

Associated gene

Dmel\drk

Associated Insertion(s)

P{PZ}drk¹⁰⁶²⁶

Carried in Construct

Also Known As

l(2)10626

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}drk¹⁰⁶²⁶

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:13,502,086..13,502,086 [+]

(Moressis et al., 2009, Spradling et al., 1999, Heuer et al., 1995, BDGP Project Members, 1994-1999, Simon et al., 1993)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates multiple endocrine neoplasia type 2B

modeled by Ret^MEN2B.GMR

(Read et al., 2005)

ameliorates multiple endocrine neoplasia type 2A

modeled by Ret^MEN2A.GMR

(Read et al., 2005)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning

(Moressis et al., 2009)

lethal | embryonic stage | rescuable maternal effect

(Perrimon et al., 1996)

lethal | larval stage | recessive

(Perrimon et al., 1996)

lethal | recessive

(Spradling et al., 1999, Simon et al., 1993)

Phenotype Manifest In

abdomen | posterior

(Perrimon et al., 1996)

embryonic/first instar larval cuticle

(Perrimon et al., 1996)

head

(Perrimon et al., 1996)

Detailed Description

Statement

Reference

Olfactory association learning is lower in drk¹⁰⁶²⁶ heterozygotes compared to controls.

(Moressis et al., 2009)

Germline clones produce eggs with patterning defects: defects in both head and tail regions.

(Perrimon et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

drk[+]/drk¹⁰⁶²⁶ is an enhancer of visible phenotype of CycE^JP

(Brumby et al., 2004)

NOT Enhancer of

Statement

Reference

drk[+]/drk¹⁰⁶²⁶ is a non-enhancer of visible | dominant phenotype of Egfr^E1

(Read et al., 2005)

drk[+]/drk¹⁰⁶²⁶ is a non-enhancer of visible phenotype of Pi3K68D^{KD.UAS.Tag:MYC}, Scer\GAL4^69B

(MacDougall et al., 2004)

Suppressor of

Statement

Reference

drk¹⁰⁶²⁶ is a suppressor of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

drk¹⁰⁶²⁶ is a suppressor of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

drk¹⁰⁶²⁶ is a suppressor of visible phenotype of Ret^GMR.PR

(Read et al., 2005)

NOT Suppressor of

Statement

Reference

drk[+]/drk¹⁰⁶²⁶ is a non-suppressor of visible | dominant phenotype of Egfr^E1

(Read et al., 2005)

drk[+]/drk¹⁰⁶²⁶ is a non-suppressor of visible phenotype of Pi3K68D^{KD.UAS.Tag:MYC}, Scer\GAL4^69B

(MacDougall et al., 2004)

Phenotype Manifest In

Enhancer of

Statement

Reference

drk[+]/drk¹⁰⁶²⁶ is an enhancer of eye phenotype of CycE^JP

(Brumby et al., 2004)

NOT Enhancer of

Statement

Reference

drk[+]/drk¹⁰⁶²⁶ is a non-enhancer of eye phenotype of Egfr^E1

(Read et al., 2005)

drk[+]/drk¹⁰⁶²⁶ is a non-enhancer of wing vein | ectopic phenotype of Pi3K68D^{KD.UAS.Tag:MYC}, Scer\GAL4^69B

(MacDougall et al., 2004)

Suppressor of

Statement

Reference

drk¹⁰⁶²⁶ is a suppressor of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

drk¹⁰⁶²⁶ is a suppressor of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

drk¹⁰⁶²⁶ is a suppressor of eye phenotype of Ret^GMR.PR

(Read et al., 2005)

NOT Suppressor of

Statement

Reference

drk[+]/drk¹⁰⁶²⁶ is a non-suppressor of eye phenotype of Egfr^E1

(Read et al., 2005)

drk[+]/drk¹⁰⁶²⁶ is a non-suppressor of wing vein | ectopic phenotype of Pi3K68D^{KD.UAS.Tag:MYC}, Scer\GAL4^69B

(MacDougall et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

drk¹⁰⁶²⁶/+ does not suppress the ectopic wing vein phenotype caused by expression of Pi3K68D^{KD.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^69B.

(MacDougall et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

drk^k13809

(BDGP Project Members, 1994-1999)

drk^k15709

(BDGP Project Members, 1994-1999)

Fails to complement

drk^k03106

(BDGP Project Members, 1994-1999)

drk^k02401

(BDGP Project Members, 1994-1999)

drk^k13913

(BDGP Project Members, 1994-1999)

drk^k15709

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

12378

P{PZ}drk¹⁰⁶²⁶ cn¹/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

A. Spradling.

Comments

Not allelic to shot.

(Gregory and Brown, 1998)

Δ2-3 mobilisation of P{PZ} reverts the recessive lethal phenotype.

(Simon et al., 1993)

Complements: Aats-val⁰³⁵³¹. Complements: shot^k05434b. Complements: arr^k08131.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

drk¹⁰⁶²⁶

(Zhang et al., 2013, Moressis et al., 2009, MacDougall et al., 2004, Settle et al., 2003)

drk^P1

(Moressis et al., 2009)

l(2)10626

(Spradling et al., 1999, Gregory and Brown, 1998, Simon et al., 1993)

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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