FlyBase Allele Report: Dmel\drk[k02401]

General Information

Symbol

Dmel\drk^k02401

Species

D. melanogaster

Name

FlyBase ID

FBal0042995

Feature type

allele

Associated gene

Dmel\drk

Associated Insertion(s)

P{lacW}drk^k02401

Carried in Construct

Also Known As

k02401

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Roch et al., 1998)

Progenitor genotype

Associated Insertion(s)

P{lacW}drk^k02401

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates multiple endocrine neoplasia type 2B

modeled by Ret^MEN2B.GMR

(Read et al., 2005)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning

(Moressis et al., 2009)

lethal | recessive

(Dworkin and Gibson, 2006, Spradling et al., 1999, Roch et al., 1998)

visible | dominant

(Dworkin and Gibson, 2006)

Phenotype Manifest In

wing | posterior

(Dworkin and Gibson, 2006)

Detailed Description

Statement

Reference

Olfactory association learning is lower in drk^k02401 heterozygotes compared to controls.

(Moressis et al., 2009)

Heterozygotes show a direct effect on the shape of the wing, having a significant effect in the posterior region, but no effect in the anterior region.

(Dworkin and Gibson, 2006)

Lethality occurs during third instar larval or pupal stages. Mutants do not show any visible disc abnormalities.

(Roch et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

drk^k02401 is a non-enhancer of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

drk^k02401 is a non-enhancer of visible phenotype of Ret^GMR.PR

(Read et al., 2005)

drk^k02401 is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

drk^k02401 is a non-enhancer of visible phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

drk^k02401 is a non-enhancer of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Suppressor of

Statement

Reference

drk^k02401 is a suppressor of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

drk^k02401/drk[+] is a suppressor of visible | dominant phenotype of Egfr^E1

(Read et al., 2005)

NOT Suppressor of

Statement

Reference

drk^k02401/drk[+] is a non-suppressor of lethal phenotype of Uba1^B1/Uba1^B2

(Yan et al., 2009)

drk^k02401 is a non-suppressor of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

drk^k02401 is a non-suppressor of visible phenotype of Ret^GMR.PR

(Read et al., 2005)

drk^k02401 is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

drk^k02401 is a non-suppressor of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

drk^k02401 is a non-suppressor of visible phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

drk^k02401 is a non-enhancer of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

drk^k02401 is a non-enhancer of eye phenotype of Ret^GMR.PR

(Read et al., 2005)

drk^k02401 is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

drk^k02401 is a non-enhancer of eye phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

drk^k02401 is a non-enhancer of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Suppressor of

Statement

Reference

drk^k02401 is a suppressor of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

drk^k02401/drk[+] is a suppressor of eye phenotype of Egfr^E1

(Read et al., 2005)

drk^k02401/drk[+] is a suppressor of adult optic lobe | adult stage phenotype of vap²

(Botella et al., 2003)

NOT Suppressor of

Statement

Reference

drk^k02401 is a non-suppressor of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

drk^k02401 is a non-suppressor of eye phenotype of Ret^GMR.PR

(Read et al., 2005)

drk^k02401 is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

drk^k02401 is a non-suppressor of eye phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

drk^k02401 is a non-suppressor of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

A drk^k02401/+ background does not suppress the ectopic cell divisions found in Uba1^B1/Uba1^B2 trans-heterozygous eye discs.

(Yan et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

drk^unspecified

(Dworkin and Gibson, 2006)

drk¹⁰⁶²⁶

(BDGP Project Members, 1994-1999)

drk^k03106

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

10372

y¹ w^67c23; P{lacW}drk^k02401/CyO

Kyoto

111070

w¹¹¹⁸; P{neoFRT}42D P{lacW}drk^k02401 /CyO y⁺

Notes on Origin

Discoverer

I. Kiss.

Comments

Complements: arr^k08131.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

24/1

(Roch et al., 1998)

drk^K02401

(Settle et al., 2003)

drk^P2

(Moressis et al., 2009)

drk^k02401

(Moressis et al., 2009, Yan et al., 2009, Dworkin and Gibson., 2006)

k02401

(Dworkin et al., 2011, Dworkin and Gibson, 2006)

l(2)k02401

(Spradling et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

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