Uba1B2/+ mutant flies display a significant decrease in lifespan as compared to wild type.
Most Uba1B2/Uba1B2 mutants die during late larval or pupal stages. The few escapers are infertile and display , climbing defects and visible abnormalities including unusually thick wing veins.
Uba1B2 homozygous and Uba1B1/Uba1B2 trans-heterozygous eye discs exhibit a significant increase in proliferation (as observed through phosphorylated His3 signal). Ectopic proliferation posterior to the morphogenetic furrow is significant enough that the region of frequent anti-pHis3 staining extends two to three times as far into the region posterior to the morphogenetic furrow.
Homozygous clones in the eye have a growth advantage compared to surrounding wild-type tissue at 18oC. At 30oC, homozygous clones in the eye result in overgrowth of surrounding wild-type tissue.
Homozygous clones in the pupal retina 46 hours after puparium formation contain additional interommatidial cells compared to control retinas (where these extra cells are eliminated by apoptosis during the mid-pupal phase).