FB2026_03 , released September 17, 2026
Allele: Dmel\drk6
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General Information
Symbol
Dmel\drk6
Species
D. melanogaster
Name
FlyBase ID
FBal0221668
Feature type
allele
Associated gene
Dmel\drk
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Kaufman, 2009.6.18)
Mutagen
ethyl methanesulfonate
(Kaufman, 2009.6.18)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  autosomal recessive nonsyndromic deafness 114
      CEA with drk14-7
      (Li et al., 2019)
      CEA with drke0A
      (Li et al., 2019)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      drk6/drk14-7 and drk6/drke0A transheterozygotes exhibit disorganized scolopidia (as revealed by phalloidin staining, which labels cap rods, scolopale rods, and the actin bundles within the cilia of the mechanosensory neurons). drk6/drk14-7 transheterozygotes also exhibit severely reduced climbing activity, suggesting defects in gravity sensing.

      (Li et al., 2019)

      drk6 exhibits a rough eye phenotype when combined with strong loss-of-function alleles.

      (Kaufman, 2009.6.18)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially complements

      drk14-7

      (Li et al., 2019)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      drk6
      (Li et al., 2019, Kaufman, 2009.6.18)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)