FlyBase Allele Report: Dmel\drk[ΔP24]

General Information

Symbol

Dmel\drk^ΔP24

Species

D. melanogaster

Name

FlyBase ID

FBal0042991

Feature type

allele

Associated gene

Dmel\drk

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Deletion of drk.

(Hou et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of autosomal recessive nonsyndromic deafness 114

CEA

(Li et al., 2019)

CEA with Hsap\GRAP^{311.UAS.Tag:HA}

(Li et al., 2019)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

drk^ΔP24 mosaic clones are made in the antenna and the eye by using the eyFLP system.

(Li et al., 2019)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal gravitaxis | somatic clone

(Li et al., 2019)

abnormal learning

(Moressis et al., 2009)

abnormal memory

(Moressis et al., 2009)

lethal

(Li et al., 2019)

lethal (with drk^e0A)

(Li et al., 2019)

partially lethal (with drk⁶)

(Li et al., 2019)

partially lethal - majority live (with drk^14-7)

(Li et al., 2019)

Phenotype Manifest In

dorsal air sac primordium | somatic clone

(Cabernard and Affolter, 2005)

scolopidium | somatic clone

(Li et al., 2019)

Detailed Description

Statement

Reference

Adults bearing whole-eye/antenna drk^ΔP24 clones have severely reduced climbing activity, suggesting defects in gravity sensing. These individuals exhibit disorganized scolopidia (as revealed by phalloidin staining, which labels cap rods, scolopale rods, and the actin bundles within the cilia of the mechanosensory neurons) and significantly smaller antennal mechanosensory motor center, indicating loss of sensory nerve terminals in the brain.

(Li et al., 2019)

Olfactory association learning is lower in drk^ΔP24 heterozygotes compared to controls. There is a 20% decrease in learning after training with 6 or less pairings.

Histological and immunohistochemical examination of drk^e0A heterozygous heads with multiple antigenic markers does not reveal and gross structural anomalies in the brain. Avoidance of odors used as CS and electroshock (US) are no different from that of controls. Heterozygous mutants exhibit normal odor avoidance after pre-exposure to electric shock.

(Moressis et al., 2009)

drk^ΔP24 homozygous clones in the dorsal air sac primordium are found at the tip of the primordium at a significantly lower frequency than wild-type clones.

(Cabernard and Affolter, 2005)

The initiation of mesoderm spreading is unaffected in embryos derived from homozygous female germline clones.

(Wilson et al., 2005)

Mutants exhibit no defects in hemocyte migration.

(Cho et al., 2002)

When mutant somatic clones are made in the border cells no effect is seen.

(Duchek et al., 2001)

Embryos derived from dos^P115 drk^ΔP24 or Shc^BG drk^ΔP24 double mutant female germline clones have a stronger phenotype than embryos derived from either single mutant female germline clone.

(Luschnig et al., 2000)

Null embryos from homozygous female germlines differentiate a significant amount of cuticle. In embryos from homozygous germlines that receive a paternal wild type drk, defects in the posterior spiracles and A8, which are common in Sos mutant embryos, are rarely observed.

(Hou et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

drk^ΔP24 has abnormal gravitaxis | somatic clone phenotype, suppressible by Scer\GAL4^elav.PU/Hsap\GRAP^{311.UAS.Tag:HA}

(Li et al., 2019)

drk^ΔP24 has abnormal learning phenotype, suppressible by Scer\GAL4^c747/Ras85D^V12.S35.UAS

(Moressis et al., 2009)

drk^ΔP24 has abnormal learning phenotype, suppressible by Scer\GAL4^c747/Raf^UAS.F179

(Moressis et al., 2009)

NOT suppressed by

Statement

Reference

drk^ΔP24 has abnormal gravitaxis | somatic clone phenotype, non-suppressible by Scer\GAL4^elav.PU/Hsap\GRAP^UAS.Tag:HA

(Li et al., 2019)

drk^ΔP24 has abnormal learning phenotype, non-suppressible by Scer\GAL4^c747/Scer\GAL80^ts.αTub84B/Ras85D^V12.S35.UAS

(Moressis et al., 2009)

drk^ΔP24 has abnormal learning phenotype, non-suppressible by Scer\GAL4^c747/Raf^UAS.F179/Scer\GAL80^ts.αTub84B

(Moressis et al., 2009)

drk^ΔP24 has abnormal memory phenotype, non-suppressible by Scer\GAL4^c747/Raf^UAS.F179

(Moressis et al., 2009)

drk^ΔP24 has abnormal memory phenotype, non-suppressible by Scer\GAL4^c747/Raf^fl.UAS

(Moressis et al., 2009)

Phenotype Manifest In

Suppressor of

Statement

Reference

drk[+]/drk^ΔP24 is a suppressor of phenotype of Src42A^Su(Raf)1-1

(Zhang et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Ras85D^{V12.S35.Scer\UAS} alone, or combined with the Scer\GAL4^c747 driver but kept silent by Scer\GAL80^ts.αTub84B does not suppress the learning deficit of drk^ΔP24/+ animals. In contrast, expression of Ras85D^{V12.S35.Scer\UAS} by inactivation of the Scer\GAL80^ts.αTub84B suppressor restores normal learning to drk^ΔP24 heterozygotes, while it does not appear to affect learning in control animals.

Expression of phl^{Scer\UAS.F179} alone, or combined with the Scer\GAL4^c747 driver but kept silent by Scer\GAL80^ts.αTub84B does not suppress the learning deficit of drk^ΔP24/+ animals. Conditional expression of phl^{Scer\UAS.F179} in adult mushroom bodies reverse the learning deficit of drk^ΔP24 heterozygotes.

Expression of phl^{Scer\UAS.F179} under the control of Scer\GAL4^c747 does not rescue 90 minute memory in drk^ΔP24/+ animals.

(Moressis et al., 2009)

Dominantly suppresses the ability of Src42A^Su(phl)1-1 to suppress the lethality of phl¹/Y flies.

(Zhang et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

drk^14-7

(Li et al., 2019)

drk⁶

(Li et al., 2019)

Fails to complement

drk^e0A

(Li et al., 2019)

Rescued by

drk^ΔP24 is rescued by drk^hs.PM

(Moressis et al., 2009)

Partially rescued by

drk^ΔP24 is partially rescued by Scer\GAL4^elav.PU/drk^UAS.cUa

(Li et al., 2019)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

T. Raabe and E. Hafen.

(Hou et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Drk^J03

(Duchek et al., 2001)

drk^Δ

(Li et al., 2019)

drk^ΔP24

(Li et al., 2019, Zhang et al., 2013, Moressis et al., 2009, Cabernard and Affolter, 2005)

drk^ΔP2

(Cho et al., 2002)

drk^Δp24

(Zhang et al., 1999)

Name Synonyms

Secondary FlyBase IDs

FBal0127235

References (11)

Report Sections

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