In EndoA^Δ4/EndoA²⁶ transheterozygotes containing a copy of EndoA^{S75A.T:Avic\GFP-CyPet}, the presynaptic region of third instar larval neuromuscular junctions fails to present the expected starvation-induced formation of autophagosomes (detected as fluorescent puncta of Atg8 or Lamp in confocal microscopy images), but presents no defects in autophagosome density under normal diet, as compared to controls; the corresponding third instar larval effector neuron axons do not present defects in autophagosome density, as compared to controls. Adults exhibit significant decreases in the number of dopaminergic PPM3 and PPL1 neurons, but not dopaminergic PPM1 and PPM2 neurons, at day 30, but not day 1, after eclosion, as compared to controls. In adults reared under constant light, but not under constant dark, the eye exhibits a significant decrease in the rhabdomere number per ommatidium and in the photoreceptor terminal number per lamina cartridge (at day 7 of light exposure), as compared to controls; the eye of individuals reared under either constant light or constant dark also exhibits a significant decrease in depolarization amplitude in response to light pulses (at day 3 of light exposure), as compared to controls.

EndoA²⁶/EndoA^Δ4, EndoA^S75A.CyPet has autophagosome | third instar larval stage | nutrition conditional phenotype, non-suppressible by Scer\GAL4^da.G32/Hsap\LRRK2^{G2019S.UAS.Tag:V5}

EndoA^S75A.CyPet is a non-suppressor of autophagosome | third instar larval stage | nutrition conditional phenotype of Lrrk^e03680