FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SynjCS.UAS
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General Information
Symbol
Dmel\SynjCS.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0327487
Feature type
allele
Associated gene
Dmel\Synj
Associated Insertion(s)
Carried in Construct
PBac{UAS-Synj.CS}
Key Links
Transgenic product class
missense_variant
(Vanhauwaert et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Vanhauwaert et al., 2017)
Mutagen
in vitro construct
(Vanhauwaert et al., 2017)
Progenitor genotype
Carried in construct
PBac{UAS-Synj.CS}
Cytology
Description

UASt regulatory sequences drive expression of a SAC1 enzymatic dead mutant of Synj (C396S amino acid replacement).

(Vanhauwaert et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Synj
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease
      CEA with Synj1, Synj2
      (Vanhauwaert et al., 2017)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      DOES NOT ameliorate  Parkinson's disease
      modeled by Synj1, Synj2
      (Vanhauwaert et al., 2017)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      SynjCS.UAS/Scer\GAL4Toll-6-D42 fails to rescue Synj2/Synj1

      (Vanhauwaert et al., 2017)
      Comments

      The expression of SynjCS.Scer\UAS under the control of Scer\GAL4Toll-6-D42 does not rescue the failure of Synj1/Synj2 transheterozygotes to starvation-induce mature autophagosomes (detected as fluorescent Atg8 puncta) at the presynaptic region of the third instar larval neuromuscular junction.

      (Vanhauwaert et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SynjCS.Scer\UAS
      SynjCS.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)