FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity ID (Ontology) GO:0004439 (Gene Ontology)
Definition Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
Also Known As "PI(4,5)P2 5-phosphatase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
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phosphatidylinositol bisphosphate phosphatase activity
 |__phosphatidylinositol-4,5-bisphosphate phosphatase activity__
phosphatidylinositol phosphate phosphatase activity             |
 |__phosphatidylinositol phosphate 5-phosphatase activity_______|
                                                                phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity  5 rec.
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Is a phosphatidylinositol phosphate 5-phosphatase activity
phosphatidylinositol-4,5-bisphosphate phosphatase activity
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Synonyms
  • "phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase activity" RELATED[ EC:3 ]
    "phosphatidylinositol 4,5-bisphosphate phosphatase activity" BROAD[ EC:3 ]
    "phosphatidylinositol-bisphosphatase activity" BROAD[ EC:3 ]
    "PI(4,5)P2 5-phosphatase activity" EXACT[ PubMed:15249580 ]
    "PtdIns(4,5)P(2) 5-phosphatase activity" RELATED[ EC:3 ]
    "PtdIns(4,5)P2 5-phosphatase activity" RELATED[ EC:3 ]
    "triphosphoinositide phosphatase activity" BROAD[ EC:3 ]
    "triphosphoinositide phosphomonoesterase activity" BROAD[ EC:3 ]
Secondary IDs
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EC:3.1.3.36
KEGG_REACTION:R04404
MetaCyc:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN
Reactome:R-HSA-1675824 "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane"
Reactome:R-HSA-1676177 "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane"
Reactome:R-HSA-8868648 "SYNJ hydrolyze PI(4,5)P2 to PI(4)P"
RHEA:22764
RHEA:43576
RHEA:86551