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General Information
Symbol
Dmel\Pknk06808
Species
D. melanogaster
Name
delorean
FlyBase ID
FBal0122034
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
transposable element insertion site
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The insertion site of P{lacW}Pknk06808 is within the first intron of Pkn. The orientation of the inserted element is identical to the direction of the transcribed strand of Pkn.

Insertion components
P{lacW}Pknk06808
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies homozygous for Pknk06808 are unable to fly and their wings are held up from the thorax and curve ventrally, similar to the open doors of a Delorean automobile. The extent of curvature is variable, from slight smooth curve to severe folded-over phenotype. The anterior wing margin is also defective: there are gaps in marginal tissue, excessive spacing between stout mechanosensory bristles, and fewer sensillae and bristles relative to heterozygous siblings. Occasionally, two or three stout bristles share a common socket, and sometimes a stout bristle appears in the margin tissue without a socket. A total of 95% of homozygous Pknk06808 flies analysed have one or more double-stout bristle clusters, and 15% have triple-stout bristle clusters.

Wing defects are only seen in homozyogus Pknk06808 flies. Heterozygous Pknk06808/+ flies have wild-type wings.

Wing vein defects, such as ectopic vein material surrounding the longitudinal vein L2, and/or extending from the posterior crossvein, are also noted.

Pknk06808/Pknk06808; Tp(2;3)eve1.18 wings do not exhibit ventral curvature and flies no longer have ante- rior wing margin bristle defects or ectopic veins associated with the delorean phenotype.

When homozygous Pknk06808 offspring are compared with heterozygous Pknk06808/+ siblings, no significant difference in viability is observed. Thus, the Pknk06808 allele is adult viable.

Unexpectedly, wing shape, anterior wing margin structures, and venation patterns of Pknk06808/Df(2R)w45-30n flies are mostly wild-type. This was seen for all deficiencies of 45C examined (Df(2R)Np3, Df(2R)Np5, and Df(2R)wun-GL).

Homozygotes have wings that stand up from the thorax and curve down. The phenotype also manifests itself in mechanosensory bristles of the anterior wing margins.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Pknk06808 has visible phenotype, enhanceable by bsk1/bsk[+]

Pknk06808 has visible phenotype, enhanceable by nmoP1/nmo[+]

Phenotype Manifest In
Enhanced by
Statement
Reference

Pknk06808 has wing phenotype, enhanceable by bsk1/bsk[+]

Pknk06808 has wing margin bristle phenotype, enhanceable by bsk1/bsk[+]

Pknk06808 has anterior wing margin phenotype, enhanceable by nmoP1/nmo[+]

Pknk06808 has wing vein | ectopic phenotype, enhanceable by nmoP1/nmo[+]

NOT Enhanced by
Statement
Reference

Pknk06808 has wing phenotype, non-enhanceable by LIMK1EY08757

NOT suppressed by
Statement
Reference

Pknk06808 has wing phenotype, non-suppressible by LIMK1EY08757

Additional Comments
Genetic Interactions
Statement
Reference

The Pknk06808 wing phenotype is enhanced by bsk1/+.

Anterior wing margin and wing crossvein defects associated with Pknk06808 are enhanced by nmoP1/+.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Etymology: mutation is named "delorean" as mutant flies have wings that stand up from the thorax and curve down, much like the open doors of a Delorean car.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Pkndelorean
Pknk06808
Secondary FlyBase IDs
    References (2)