Open Close
Reference
Citation
Kim, J.H., Wang, X., Coolon, R., Ye, B. (2013). Dscam expression levels determine presynaptic arbor sizes in Drosophila sensory neurons.  Neuron 78(5): 827--838.
FlyBase ID
FBrf0221817
Publication Type
Research paper
Abstract

Expression of the Down syndrome cell-adhesion molecule (Dscam) is increased in the brains of patients with several neurological disorders. Although Dscam is critically involved in many aspects of neuronal development, little is known about either the mechanism that regulates its expression or the functional consequences of dysregulated Dscam expression. Here, we show that Dscam expression levels serve as an instructive code for the size control of presynaptic arbor. Two convergent pathways, involving dual leucine zipper kinase (DLK) and fragile X mental retardation protein (FMRP), control Dscam expression through protein translation. Defects in this regulation of Dscam translation lead to exuberant presynaptic arbor growth in Drosophila somatosensory neurons. Our findings uncover a function of Dscam in presynaptic size control and provide insights into how dysregulated Dscam may contribute to the pathogenesis of neurological disorders.

PubMed ID
PubMed Central ID
PMC3709448 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

UAS-Dscam1 constructs associated with Kim et al., 2013 (FBrf0221817).
Ye, 2016.8.19, UAS-Dscam1 constructs associated with Kim et al., 2013 (FBrf0221817). [FBrf0233383]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference