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General Information
Symbol
Dmel\wnd3
Species
D. melanogaster
Name
FlyBase ID
FBal0194611
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
transposable element insertion site
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

wnd3 contains a roo\ORF transposon insertion at residue 548.

Insertion components
roo{}wnd3
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

wnd1/wnd3 transheterozygotes do not show grooming defects, nor any obvious adult mushroom body defects.

wnd3/wnd3, but not wnd3/+, leads to a suppressed growth response of motoneuron axons after nerve crush injury in third instar larvae, as compared to wild type.

wnd1/wnd3 animals show severely reduced axon outgrowth in ddaC neurons after axon severing, while dendrite regeneration after complete removal of the dendrites appears normal.

wnd3/Df(3L)ED229 larvae show an increase in maximum bouton diameter at the neuromuscular junction compared to controls.

Under control conditions, wnd2/wnd3 transheterozygous third instar larvae do not display significant changes in the number of sensory axons per nerve, as compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Other
Additional Comments
Genetic Interactions
Statement
Reference

Trpml1/+;wnd3/+ double heterozygotes show decreased number of NMJ boutons in third instar larvae compared to either Trpml1/+ or wnd3/+ single heterozygotes.

The increased number of neuromuscular junction boutons in third instar larvae expressing RhebScer\UAS.cSa under the Scer\GAL4elav-C155 driver is significantly suppressed by combination with wnd3/+.

wnd2/wnd3 fully suppresses the increase in bouton number seen at the neuromuscular junction in shot3/shotVV third instar larvae.

A wnd3 background suppresses the bouton number increase and the reduction in bouton size seen in Rae1EX28 mutants.

The synaptic overgrowth phenotypes seen at the neuromuscular junction in Fsnf06595/Df(2R)Exel7124 larvae (increased bouton number, increased number of branch points and increased synaptic span) are completely suppressed by wnd3.

wnd3 can fully suppress the hiwND8 synaptic overgrowth phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of wndScer\UAS.cCa, but not wndS301A.S305A.Scer\UAS, under the control of Scer\GAL4eve.RRa rescues the suppressed growth response of motoneuron axons after nerve crush injury seen in wnd3/wnd3 mutant larvae.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Arose in: hiwPF253 stock.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (15)