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General Information
Symbol
Dmel\shotVV
Species
D. melanogaster
Name
FlyBase ID
FBal0294003
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous and shot3/shotVV third instar larvae show overgrowth (increase in bouton number) at the neuromuscular junction.

shot3/shotVV axons show enhanced regenerative axonal sprouting compared to controls after a crushing injury.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

wnd2/+ partially suppresses the increase in bouton number seen at the neuromuscular junction in shot3/shotVV third instar larvae.

wnd2/wnd3 fully suppresses the increase in bouton number seen at the neuromuscular junction in shot3/shotVV third instar larvae.

Expression of either kayFbz.Scer\UAS or bskK53R.Scer\UAS under the control of Scer\GAL4elav.PU suppresses the increase in bouton number seen at the neuromuscular junction in shot3/shotVV third instar larvae.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments

Expression of shotLA.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4elav.PU rescues the increase in bouton number seen at the neuromuscular junction in shot3/shotVV third instar larvae, while expression under the control of Scer\GAL4how-24B fails to rescue the phenotype.

Expression of either shotLA-ΔPlakin.Scer\UAS.T:Avic\GFP or shotLA-Δrod1.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4elav.PU rescues the increase in bouton number seen at the neuromuscular junction in shot3/shotVV third instar larvae.

Expression of either shotLC.Scer\UAS.T:Avic\GFP, shotLA-ΔEF-hand.Scer\UAS.T:Avic\GFP or shotLA-ΔGAS2.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4elav.PU fails to rescue the increase in bouton number seen at the neuromuscular junction in shot3/shotVV third instar larvae.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)