FB2026_02 , released June 18, 2026
Allele: Dmel\hiwND69
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General Information
Symbol
Dmel\hiwND69
Species
D. melanogaster
Name
FlyBase ID
FBal0118197
Feature type
allele
Associated gene
Dmel\hiw
Associated Insertion(s)
Carried in Construct
Also Known As
ND69
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Wan et al., 2000)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: Y3173term.

    (Wan et al., 2000)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    X:15,017,504..15,017,504 [-]
    Nucleotide change:

    T15017504R

    Amino acid change:

    Y3173term | hiw-PA; Y3173term | hiw-PB

    Reported amino acid change:

    Y3173term

    Comment:

    The site of the nucleotide substitution in the mutant was inferred by FlyBase based on the reported amino acid change.

    (Wan et al., 2000)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        exacerbates  tuberous sclerosis
        modeled by Tsc1UAS.cTa, gigUAS.cTa
        (Murthy et al., 2004)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Homozygotes or hemizygotes over Df(1)RK2 or Df(1)RK4 all have synapses that are longer and more branched with more numerous but smaller boutons.

        (Wan et al., 2000)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The small eye phenotype caused by co-expression of gigScer\UAS.cTa and Tsc1Scer\UAS.cTa under the control of Scer\GAL4ey.PH is enhanced by hiwND69.

        (Murthy et al., 2004)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        ND69
        (Wu et al., 2005, Murthy et al., 2004)
        hiwND69
        Name Synonyms
        Secondary FlyBase IDs
          References (3)