FlyBase Allele Report: Dmel\Atg6[RNAi.UAS]

General Information

Symbol

Dmel\Atg6^RNAi.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0215194

Feature type

allele

Associated gene

Dmel\Atg6

Associated Insertion(s)

Carried in Construct

P{UAS-Atg6.RNAi}

Key Links

Transgenic product class

RNAi_reagent

(Pandey et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Pandey et al., 2007)

Mutagen

in vitro construct

(Pandey et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-Atg6.RNAi}

Cytology

Description

Template containing Atg6 sequences.

(Pandey et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Atg6

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Kennedy's disease

modeled by Hsap\AR^Q52.UAS

(Pandey et al., 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Atg6^RNAi.UAS, Scer\GAL4^GMR.PU is an enhancer of visible | drug conditional phenotype of Hsap\AR^Q52.UAS, Scer\GAL4^GMR.PU

(Pandey et al., 2007)

Atg6^RNAi.UAS, Scer\GAL4^GMR.PU is an enhancer of visible | heat sensitive phenotype of Prosβ2^1.UAS, Scer\GAL4^GMR.PU

(Pandey et al., 2007)

NOT Enhancer of

Statement

Reference

Atg6^RNAi.UAS, Scer\GAL4^GMR.long is a non-enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.long, Zzzz\CGG^90.UAS.EGFP

(Oh et al., 2015)

Phenotype Manifest In

Enhancer of

Statement

Reference

Atg6^RNAi.UAS, Scer\GAL4^GMR.PU is an enhancer of eye | drug conditional phenotype of Hsap\AR^Q52.UAS, Scer\GAL4^GMR.PU

(Pandey et al., 2007)

Atg6^RNAi.UAS, Scer\GAL4^GMR.PU is an enhancer of eye | heat sensitive phenotype of Prosβ2^1.UAS, Scer\GAL4^GMR.PU

(Pandey et al., 2007)

NOT Enhancer of

Statement

Reference

Atg6^RNAi.UAS, Scer\GAL4^GMR.long is a non-enhancer of eye phenotype of Scer\GAL4^GMR.long, Zzzz\CGG^90.UAS.EGFP

(Oh et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The rough eye phenotype seen in flies expressing Prosβ2^1.Scer\UAS under the control of Scer\GAL4^GMR.PF at 28^oC is enhanced by co-expression of Atg6^{dsRNA.Scer\UAS}.

(Pandey et al., 2007)

Xenogenetic Interactions

Statement

Reference

The eye degeneration phenotype observed in adult flies expressing Zzzz\CGG^{90.Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.long (and maintained at 28[o]C) is not modified by co-expression of Atg6^{dsRNA.Scer\UAS}.

(Oh et al., 2015)

The rough eye phenotype seen in flies expressing Hsap\AR^Q52.Scer\UAS under the control of Scer\GAL4^GMR.PF in the presence of dihydrotestosterone (DHT) is enhanced by co-expression of Atg6^{dsRNA.Scer\UAS}.

(Pandey et al., 2007)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Used to study the phenotypic consequences of dsRNA interference (RNAi) of the Atg6 gene.

(Pandey et al., 2007)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Atg6^RNAi.UAS

Atg6^{dsRNA.Scer\UAS}

Atg6^dsRNA.UAS

atg6^KD

(Pandey et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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