FlyBase Allele Report: Dmel\unc-45[EY03034]

General Information

Symbol

Dmel\unc-45^EY03034

Species

D. melanogaster

Name

FlyBase ID

FBal0159659

Feature type

allele

Associated gene

Dmel\unc-45

Associated Insertion(s)

P{EPgy2}unc-45^EY03034

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}unc-45^EY03034

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:8,033,349..8,033,349 [+]

(Lee et al., 2011, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Gene Disruption Project members, 2001-)

lethal - all die before end of larval stage

(Lee et al., 2011)

some die during third instar larval stage

(Lee et al., 2011)

viable

(Gene Disruption Project members, 2001-)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

unc-45^EY03034/Scer\GAL4^GMR.PU is a suppressor of visible phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PS/unc-45^EY03034 is a suppressor of visible phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Phenotype Manifest In

Suppressor of

Statement

Reference

unc-45^EY03034/Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PS/unc-45^EY03034 is a suppressor of eye phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of unc-45^EY03034 under the control of Scer\GAL4^GMR.PS suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

Expression of unc-45^EY03034 suppresses the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PS.

(Ambegaokar and Jackson, 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

19664

y¹ w^67c23; P{EPgy2}unc-45^EY03034

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Tom34^EY03034

(Lee et al., 2011)

unc-45^EY03034

(Ambegaokar and Jackson, 2011)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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