FB2026_02 , released June 18, 2026
Allele: Dmel\miltEY14443
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General Information
Symbol
Dmel\miltEY14443
Species
D. melanogaster
Name
FlyBase ID
FBal0249020
Feature type
allele
Associated gene
Dmel\milt
Associated Insertion(s)
P{EPgy2}miltEY14443
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Bellen, 2008.5.7)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}miltEY14443
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  tauopathy
      modeled by Hsap\MAPTGMR.Ex.PJ
      (Ambegaokar and Jackson, 2011)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      miltEY14443 homozygous mutant MARCM clones of glutamatergic neurons in the proximal wing have a failure of mitochondrial transport into the proximal axons, compared to controls.

      (Smith et al., 2019)

      ERG recordings from miltEY14443 homozygous mutant clones in the eye show no off-transient.

      (Huang et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      milt[+]/miltEY14443 is a suppressor of visible phenotype of Hsap\MAPTGMR.Ex.PJ

      (Ambegaokar and Jackson, 2011)

      Scer\GAL4GMR.PS/miltEY14443 is a suppressor of visible phenotype of Hsap\MAPTGMR.Ex.PJ

      (Ambegaokar and Jackson, 2011)
      NOT Suppressor of
      Statement
      Reference

      milt[+]/miltEY14443 is a non-suppressor of visible phenotype of Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS

      (Ambegaokar and Jackson, 2011)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      milt[+]/miltEY14443 is a suppressor of eye phenotype of Hsap\MAPTGMR.Ex.PJ

      (Ambegaokar and Jackson, 2011)

      Scer\GAL4GMR.PS/miltEY14443 is a suppressor of eye phenotype of Hsap\MAPTGMR.Ex.PJ

      (Ambegaokar and Jackson, 2011)
      NOT Suppressor of
      Statement
      Reference

      milt[+]/miltEY14443 is a non-suppressor of eye phenotype of Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS

      (Ambegaokar and Jackson, 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      One copy of miltEY14443 under the control of Scer\GAL4GMR.PS suppresses the rough eye phenotype seen in flies expressing Hsap\MAPTGMR.Ex.PJ. The same phenotype is seen when miltEY14443 is expressed under the control of Scer\GAL4GMR.PU.

      One copy of miltEY14443 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

      (Ambegaokar and Jackson, 2011)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      CG31630EY14443
      (Ambegaokar and Jackson, 2011, Bellen, 2008.5.7)
      HAP1-LOF
      (Kim et al., 2021)
      Milton EY4443
      (Smith et al., 2019)
      miltEY14443
      (Huang et al., 2015, Bellen, 2008.5.7)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0215892
      • FBal0215891
      References (6)