FlyBase Allele Report: Dmel\Vha14-1[EY12998]

General Information

Symbol

Dmel\Vha14-1^EY12998

Species

D. melanogaster

Name

FlyBase ID

FBal0159552

Feature type

allele

Associated gene

Dmel\Vha14-1

Associated Insertion(s)

P{EPgy2}Vha14-1^EY12998

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}Vha14-1^EY12998

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:15,679,556..15,679,556 [+]

(Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Vha14-1[+]/Vha14-1^EY12998 is an enhancer | male limited of visible | heat sensitive phenotype of Ivir\M2^UAS.cAa, Scer\GAL4^GMR.PU

(Adamson et al., 2011)

Suppressor of

Statement

Reference

Vha14-1[+]/Vha14-1^EY12998 is a suppressor of visible phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PS/Vha14-1^EY12998 is a suppressor of visible phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

NOT Suppressor of

Statement

Reference

Vha14-1[+]/Vha14-1^EY12998 is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

Phenotype Manifest In

Enhancer of

Statement

Reference

Vha14-1[+]/Vha14-1^EY12998 is an enhancer | male limited of eye | heat sensitive phenotype of Ivir\M2^UAS.cAa, Scer\GAL4^GMR.PU

(Adamson et al., 2011)

Suppressor of

Statement

Reference

Vha14-1[+]/Vha14-1^EY12998 is a suppressor of wing | adult stage phenotype of Mitf^UAS.cZa, Scer\GAL4^dpp.blk1

(Zhang et al., 2015)

Vha14-1[+]/Vha14-1^EY12998 is a suppressor of eye phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Scer\GAL4^GMR.PS/Vha14-1^EY12998 is a suppressor of eye phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

NOT Suppressor of

Statement

Reference

Vha14-1[+]/Vha14-1^EY12998 is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

Additional Comments

Genetic Interactions

Statement

Reference

The small underdeveloped wing characteristic for adult flies expressing Mitf^Scer\UAS.cZa under the control of Scer\GAL4^dpp.blk1 is significantly suppressed by combination with a single copy of Vha14-1^EY12998.

(Zhang et al., 2015)

Xenogenetic Interactions

Statement

Reference

One copy of Vha14-1^EY12998 under the control of Scer\GAL4^GMR.PS suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ. The same phenotype is seen when Vha14-1^EY12998 is expressed under the control of Scer\GAL4^GMR.PU.

One copy of Vha14-1^EY12998 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

(Ambegaokar and Jackson, 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

20850

y¹ w^67c23; P{EPgy2}Vha14-1^EY12998/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Vha14-1^EY12998

(Ambegaokar and Jackson, 2011)

Vha14^EY12998

vha14-1^EY12998

(Adamson et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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