FlyBase Allele Report: Dmel\cana[k07716]

General Information

Symbol

Dmel\cana^k07716

Species

D. melanogaster

Name

FlyBase ID

FBal0064372

Feature type

allele

Associated gene

Dmel\cana

Associated Insertion(s)

P{lacW}cana^k07716

Carried in Construct

Also Known As

l(2)k07716

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(FlyBase Genome Annotators, 2002-2003, Yucel et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}cana^k07716

Cytology

Description

The P{lacW}cana^k07716 insertion maps within a dicistronic processed transcript that encodes two non-overlapping open reading frames (cana and CG33695).

(FlyBase Genome Annotators, 2002-2003)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:11,278,135..11,278,135 [+]

(Ciapponi et al., 2004, FlyBase Genome Annotators, 2002-2003, Yucel et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

lethal - all die before end of larval stage | recessive

(Yucel et al., 2000)

some die during larval stage | recessive

(Yucel et al., 2000)

Phenotype Manifest In

larval brain | larval stage

(Yucel et al., 2000)

Detailed Description

Statement

Reference

Homozygotes die as late larvae. Larval brains show an increased mitotic index compared to wild type. There is a dramatic increase in anaphase figures.

(Yucel et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

cana^k07716/cana[+] is an enhancer of visible phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

NOT Suppressor of

Statement

Reference

cana^k07716/Scer\GAL4^GMR.PU is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

Phenotype Manifest In

Enhancer of

Statement

Reference

cana^k07716/cana[+] is an enhancer of eye phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

NOT Suppressor of

Statement

Reference

cana^k07716/Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\CAG^Q108.UAS

(Ambegaokar and Jackson, 2011)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of cana^k07716 does not suppress the apoptosis seen in flies overexpressing hid.

(Ambegaokar and Jackson, 2011)

Xenogenetic Interactions

Statement

Reference

One copy of cana^k07716 enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

Expression of cana^k07716 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

(Ambegaokar and Jackson, 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

10680

y¹ w^67c23; P{lacW}cana^k07716 CG33695^k07716/CyO

Kyoto

111222

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{lacW}cana^k07716 P{neoFRT}40A/CyO y⁺

Notes on Origin

Discoverer

I. Kiss.

(BDGP Project Members, 1994-1999)

Comments

Complements: l(2)k00224^k00224. Complements: ab^k02807. Complements: RfC38^k13807.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

cana^K07716

(Ambegaokar and Jackson, 2011, Ciapponi et al., 2004)

cana^k07716

(Lee et al., 2013)

l(2)00716

(Yucel et al., 2000)

l(2)k07716

(Yucel et al., 2000, Spradling et al., 1999)

l(2)k07716^k07716

(BDGP Project Members, 1994-1999)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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