One week after eclosion, homozygous ebik16213 eye clones form ommatidia with a near-normal set of photoreceptors. At 5 weeks, however, these cells show a severely degenerated phenotype in a cell-autonomous manner. Several scar-like defects appear in the retinas along with abnormal ommatidia with a reduced number of photoreceptor cells.
Eyes containing large ebik16213 clones have a mildly rough phenotype.
Flies with retinae containing large ebik16213 clones cultured under constant illumination show severe degeneration by 14 days after eclosion, whereas wild- type ommatidia do not show any structural changes under the same conditions. In contrast, when mutant flies are raised under constant darkness, the eye phenotype remains mild 4 weeks after eclosion.
ebiP7/ebik16213 wings are 82% the size of control wings. Gross defects in wing patterning are not apparent. There is no significant decrease in the size of other organs or the whole organism.
The average number of crystal cells per embryo is reduced (to 13.6) in homozygous stage 13-14 embryos compared to wild type (36 +/- 2.2 cells on average). Mutant stage 14 embryos show cell cycle defects in the head region.