FlyBase Allele Report: Dmel\ebi[CC3]

General Information

Symbol

Dmel\ebi^CC3

Species

D. melanogaster

Name

FlyBase ID

FBal0119260

Feature type

allele

Associated gene

Dmel\ebi

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Boulton et al., 2000)

Progenitor genotype

Cytology

Description

Nucleotide substitution: C?T.

(Marygold et al., 2011)

The TCC codon encoding S602 in the 6th WD repeat is changed to TTC.

(Marygold et al., 2011)

Amino acid replacement: S602F.

(Boulton et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:417,336..417,336 [+]

Nucleotide change:

C417336T

Reported nucleotide change:

C?T

Amino acid change:

S602F | ebi-PA

Reported amino acid change:

S602F

Comment:

TCC to TTC mutation in codon 602.

(Marygold et al., 2011)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size (with ebi^P7)

(Marygold et al., 2011)

lethal (with ebi^P7)

(Marygold et al., 2011)

Phenotype Manifest In

wing (with ebi^P7)

(Marygold et al., 2011)

wing pouch (with ebi^P7)

(Marygold et al., 2011)

Detailed Description

Statement

Reference

ebi^P7/ebi^CC3 males occasionally show an overall reduction in body size, but their wings are still disproportionately small.

The wing pouch of ebi^P7/ebi^CC3 larval wing discs is reduced to about a quarter of its normal size.

(Marygold et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

ebi[+]/ebi^CC3 is an enhancer of abnormal size phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096

(Marygold et al., 2011)

ebi[+]/ebi^CC3 is an enhancer of abnormal size phenotype of Scer\GAL4^Bx-MS1096, aos^UAS.cMa

(Marygold et al., 2011)

Phenotype Manifest In

Enhancer of

Statement

Reference

ebi[+]/ebi^CC3 is an enhancer of wing phenotype of Pi3K92E^{D954A.UAS.Tag:MYC}, Scer\GAL4^Bx-MS1096

(Marygold et al., 2011)

ebi[+]/ebi^CC3 is an enhancer of wing vein phenotype of Scer\GAL4^Bx-MS1096, aos^UAS.cMa

(Marygold et al., 2011)

ebi[+]/ebi^CC3 is an enhancer of wing margin phenotype of sd^ETX4

(Marygold et al., 2011)

ebi^CC3 is an enhancer of eye phenotype of BacA\p35^GMR.PH, Dp^GMR.PD, E2f1^GMR.PD

(Boulton et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity for ebi^CC3 enhances the small wing phenotype induced by Scer\GAL4^Bx-MS1096-mediated expression of Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC}.

Heterozygosity for ebi^CC3 enhances the small wing and wing vein loss phenotypes induced by Scer\GAL4^Bx-MS1096-mediated expression of aos^Scer\UAS.cMa.

Heterozygosity for ebi^CC3 enhances the notched wing margin phenotype seen in sd^ETX4 hemizygous males.

(Marygold et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

ebi^k16213

(Boulton et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ebi^CC3

(Marygold et al., 2011)

ebi^S602F

(Marygold et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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