FlyBase Allele Report: Dmel\bon[S048706]

General Information

Symbol

Dmel\bon^S048706

Species

D. melanogaster

Name

FlyBase ID

FBal0083058

Feature type

allele

Associated gene

Dmel\bon

Associated Insertion(s)

P{lacW}bon^S048706

Carried in Construct

Also Known As

bon⁴⁸⁷

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Deak et al., 1997)

P-element activity

(Szeged Stock Center, 1998-, Salzberg et al., 1997)

Progenitor genotype

Associated Insertion(s)

P{lacW}bon^S048706

Cytology

Description

P{lacW} insertion in the middle of intron 1.

(Beckstead et al., 2001)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

abdominal sternite bristle (with bon^S024108)

(Beckstead et al., 2001)

abdominal tergite & macrochaeta (with bon^S024108)

(Beckstead et al., 2001)

embryonic/larval salivary gland (with bon^21B)

(Beckstead et al., 2001)

eye | P-stage (with bon^21B)

(Beckstead et al., 2001)

head | P-stage (with bon^21B)

(Beckstead et al., 2001)

neuron | embryonic stage

(Salzberg et al., 1997)

pupal abdomen & cuticle (with bon^S024108)

(Beckstead et al., 2001)

wing (with bon^S024108)

(Beckstead et al., 2001)

wing | P-stage (with bon^21B)

(Beckstead et al., 2001)

wing margin bristle (with bon^S024108)

(Beckstead et al., 2001)

Detailed Description

Statement

Reference

bon^S048706/+ suppresses the variegation of the y gene in the P{SUPor-P}25-4-3 insertion.

(Beckstead et al., 2005)

Most bon^S048706/bon^21B pupae have an almost complete lack of pigmentation. They initiate but fail to complete development of the legs, wings, head, eyes and cuticle. Salivary glands are still present 4 days post-pupariation (they normally undergo apoptosis at 12 hours post-pupariation) and are similar in size to third instar salivary glands. bon^S024108/bon^S048706 pharate adults show defects in cuticle and bristle development; the abdominal cuticle is immature and the tergite and sternal bristles are severely reduced or absent. The anterior wing margin bristles are almost completely missing. There is a dramatic reduction in pigmentation of the wing cuticle.

(Beckstead et al., 2001)

Embryos exhibit two extra neurons located anteriorly to each dorsal cluster and one or two very large and round cells darkly stained with the MAb 22C10 are found posterior to the v' cluster.

(Salzberg et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

bon^S048706/bon[+] is an enhancer of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

bon^S048706/bon[+] is an enhancer of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

bon^S048706/bon[+] is an enhancer of visible phenotype of Ret^GMR.PR

(Read et al., 2005)

Suppressor of

Statement

Reference

bon^S048706/bon[+] is a suppressor of visible | dominant phenotype of Egfr^E1

(Read et al., 2005)

bon^S048706/bon[+] is a suppressor | partially of lethal phenotype of ftz-f1^ex17/Df(3L)Cat

(Beckstead et al., 2001)

bon^S048706/bon[+] is a suppressor of partially lethal | recessive phenotype of ftz-f1^ex17

(Beckstead et al., 2001)

Phenotype Manifest In

Enhancer of

Statement

Reference

bon^S048706/bon[+] is an enhancer of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

bon^S048706/bon[+] is an enhancer of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

bon^S048706/bon[+] is an enhancer of eye phenotype of Ret^GMR.PR

(Read et al., 2005)

Suppressor of

Statement

Reference

bon^S048706/bon[+] is a suppressor of eye phenotype of Egfr^E1

(Read et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

87% of ftz-f1^ex17/Df(3L)Cat animals are rescued to the pharate adult stage by one copy of bon^S048706. The number of homozygous ftz-f1^ex17 adult escapers is increased by one copy of bon^S048706 (72%).

(Beckstead et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

bon^21B

(Beckstead et al., 2001)

Partially rescued by

bon^S024108/bon^S048706 is partially rescued by bon^{Hsp83.Tag:FLAG}

(Beckstead et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

4543

y¹ w^67c23; P{lacW}bon^S048706/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

Comments

Allelic series: Df(3R)H-B79 > bon^21B > bon^S048706 > bon^S024108 = bon^S024912.

(Beckstead et al., 2001)

Δ2-3 induced reversion demonstrates the insertion is responsible for the lethal phenotype.

(Salzberg et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

0487/06

(Deak et al., 1997)

487/6

(Salzberg et al., 1997)

bon⁴⁸⁷

(Zhao et al., 2023, Beckstead et al., 2005, Beckstead et al., 2001)

bon^S048706

bon^S48

(Ito et al., 2012)

l(3)S048706

(Bloomington Drosophila Stock Center, 1998.6.3)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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