FB2022_02, released March 29, 2022

Allele: Mmus\Neurog1UAS.cQa

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General Information
Symbol
Mmus\Neurog1UAS.cQa
Species
M. musculus
Name
FlyBase ID
FBal0160183
Feature type
allele
Associated gene
Mmus\Neurog1
Associated Insertion(s)
Carried in Construct
P{UAS-Neurog1.Q}
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - regulatory fusion
(Quan et al., 2004)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{UAS-Neurog1.Q}
      Cytology
      Nature of the lesion
      Statement
      Reference

      Expression of the coding region of Mmus\Neurog1 is under the control of UAS sequences.

      (Quan et al., 2004)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UAS
      Encoded product / tool
      Mmus\Neurog1
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      macrochaeta & wing | ectopic, with Scer\GAL4dpp.blk1

      (Quan et al., 2004)
      Detailed Description
      Statement
      Reference

      Expression of Mmus\Neurog1Scer\UAS.cQa driven by Scer\GAL4dpp.blk1 does not lead to neurogenesis (no ectopic sensory organ precursors) in third instar larval wing discs.

      (Yuan et al., 2016)

      Mmus\Neurog1Scer\UAS.cQa; Scer\GAL4dpp.blk1 flies have occasional ectopic bristles on their wings, but never have ectopic chordotonal organs. (Note: This phenotype is insertion dependent. It has only been seen in 7/23 lines tested, with a maximum penetrance of 70%.) Late stage Mmus\Neurog1Scer\UAS.cQa; Scer\GAL4da.G32 embryos do not have ectopic neurons.

      (Quan et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Mmus\Neurog1UAS.cQa, Scer\GAL4dpp.blk1 has macrochaeta & wing | ectopic phenotype, enhanceable by Df(1)N-8/+

      (Quan et al., 2004)
      NOT Enhanced by
      Statement
      Reference

      Mmus\Neurog1UAS.cQa, Scer\GAL4dpp.blk1 has macrochaeta & wing | ectopic phenotype, non-enhanceable by E(spl)m8-HLHunspecified

      (Quan et al., 2004)

      Mmus\Neurog1UAS.cQa, Scer\GAL4dpp.blk1 has macrochaeta & wing | ectopic phenotype, non-enhanceable by Mmus\Neurog2UAS.cQa

      (Quan et al., 2004)

      Mmus\Neurog1UAS.cQa, Scer\GAL4dpp.blk1 has macrochaeta & wing | ectopic phenotype, non-enhanceable by Mmus\Neurod4UAS.cQa

      (Quan et al., 2004)
      Suppressed by
      Statement
      Reference

      Mmus\Neurog1UAS.cQa, Scer\GAL4dpp.blk1 has macrochaeta & wing | ectopic phenotype, suppressible by E(spl)m8-HLHUAS.cTa

      (Quan et al., 2004)

      Mmus\Neurog1UAS.cQa, Scer\GAL4dpp.blk1 has macrochaeta & wing | ectopic phenotype, suppressible by E(spl)mδ-HLHUAS.cdCa

      (Quan et al., 2004)

      Mmus\Neurog1UAS.cQa, Scer\GAL4dpp.blk1 has macrochaeta & wing | ectopic phenotype, suppressible by Nintra.GS.UAS

      (Quan et al., 2004)
      NOT Enhancer of
      Statement
      Reference

      Mmus\Neurog1UAS.cQa is a non-enhancer of microchaeta & scutellum | ectopic phenotype of Scer\GAL4cv-c-C5/Scer\GAL4C5, sensUAS.cNa

      (Quan et al., 2004)
      NOT Suppressor of
      Statement
      Reference

      Mmus\Neurog1UAS.cQa/Scer\GAL47 is a non-suppressor of eye disc phenotype of ato1

      (Quan et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Ectopic bristle formation in the wings of Mmus\Neurog1Scer\UAS.cQa; Scer\GAL4dpp.blk1 flies is not enhanced by Mmus\Neurog2Scer\UAS.cQa or Mmus\Neurod4Scer\UAS.cQa. Mmus\Neurog1Scer\UAS.cQa; Scer\GAL47 does not rescue eye disc phenotypes in ato1 homozygous animals. The ectopic sensory bristle phenotype in the wings of Mmus\Neurog1Scer\UAS.cQa; Scer\GAL4dpp.blk1 animals is enhanced by Df(1)N-8/+, and completely suppressed by E(spl)Scer\UAS.cTa, HLHmδScer\UAS.cdCa or Nintra.GS.Scer\UAS.

      (Quan et al., 2004)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mmus\Neurog1Scer\UAS.cQa
      Mmus\Neurog1UAS.cQa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)