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General Information
Symbol
Dmel\E(spl)m8-HLHUAS.cTa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Tata
FlyBase ID
FBal0052454
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-m8, UAS-E(spl)m8
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Expression of the E(spl)m8-HLH coding region is governed by UASt regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of E(spl)Scer\UAS.cTa under the control of Scer\GAL4sca-C253 results in a loss of thoracic bristles in the adult fly.

Flies expressing E(spl)Scer\UAS.cTa under the control of Scer\GAL4dpp.blk1 have missing scutellar bristles.

Flies expressing E(spl)Scer\UAS.cTa under the control of Scer\GAL4dpp.blk1 show loss of scutellar bristles.

Formation of sensory organ precursors (SOPs) of the femoral chordotonal sense organ is suppressed in leg discs in which E(spl)Scer\UAS.cTa is expressed under the control of Scer\GAL4sca-109-68.

When expression is driven by Scer\GAL4hs.PB, with two heat pulses of 45 minutes 8-24hr APF, adult flies display a variety of bristle phenotypes in two categories: bristle organ loss and aberrant bristle structures (e.g. double sockets, split shaft, multiple shafts or stunted/deformed bristle shafts). Earlier heat pulses promote bristle loss, later heat pulses promote aberrant bristles. When expression is driven by Scer\GAL4hs.PB, induced between 8 and 14 hr APF, microchaetae fail to develop. The neurons in the nota are correspondingly reduced or absent. When expression is driven by Scer\GAL4hs.PB, heat shock applied to late third instar larvae leads to a marked loss of notum macrochaetae, campaniform sensillae of the anterior crossvein and the third wing vein, and chemosensory bristles on the wing margin. When expression is driven by Scer\GAL4hs.PB, heat shocked at 15hr APF, gaps appear in the wing veins.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT suppressed by
Suppressor of
Phenotype Manifest In
Suppressed by
NOT suppressed by
Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

The loss of thoracic bristles seen in adults expressing E(spl)Scer\UAS.cTa under the control of Scer\GAL4sca-C253 is suppressed by co-expression of dgrnScer\UAS.P\T.cBa but is not suppressed by co-expression of either dgrnHCAA.Scer\UAS.P\T or dgrnΔSIMs.Scer\UAS.P\T.

Expression of both sensScer\UAS.cNa and E(spl)Scer\UAS.cTa under the control of Scer\GAL4dpp.blk1 results in a strong reduction in supernumerary bristles (seen when sensScer\UAS.cNa is expressed alone under the control of Scer\GAL4dpp.blk1) in most areas and occasionally loss of bristles.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
E(spl)Scer\UAS.cTa
E(spl)UAS.cTa
E(spl)m8-HLHScer\UAS.cTa
E(spl)m8-HLHUAS.cTa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Tata
Secondary FlyBase IDs
    References (12)