When Wnt5EY03178 is driven by Scer\GAL4sim.PS a marked reduction or complete loss of anterior commissures (ACs) is seen in 43% of segments. The affected AC axons appear to stall or project ipsilaterally within the longitudinal connectives.
Scer\GAL4sim.PS, Wnt5EY03178 has larval anterior commissure phenotype, suppressible by drlRed2
The addition of homozygous drlRed2 to Wnt5EY03178, drlRed2 embryos completely suppresses the loss of anterior commissures (ACs), although abnormal projections between the ACs and the posterior commissures remain.