FB2025_01 , released February 20, 2025
Allele: Dmel\Wnt5EY03178
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General Information
Symbol
Dmel\Wnt5EY03178
Species
D. melanogaster
Name
FlyBase ID
FBal0144485
Feature type
allele
Associated gene
Dmel\Wnt5
Associated Insertion(s)
P{EPgy2}Wnt5EY03178
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Yoshikawa et al., 2003)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}Wnt5EY03178
Cytology
Description

The P{EPgy2} insertion is 23bp upstream of the transcriptional start site for Wnt5.

(Yoshikawa et al., 2003)
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When Wnt5EY03178 is driven by Scer\GAL4sim.PS a marked reduction or complete loss of anterior commissures (ACs) is seen in 43% of segments. The affected AC axons appear to stall or project ipsilaterally within the longitudinal connectives.

      (Yoshikawa et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Scer\GAL4sim.PS, Wnt5EY03178 has larval anterior commissure phenotype, suppressible by drlRed2

      (Yoshikawa et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The addition of homozygous drlRed2 to Wnt5EY03178, drlRed2 embryos completely suppresses the loss of anterior commissures (ACs), although abnormal projections between the ACs and the posterior commissures remain.

      (Yoshikawa et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Wnt5EY03178
      Name Synonyms
      Secondary FlyBase IDs
        References (1)