FlyBase Allele Report: Dmel\Vang[A3]

General Information

Symbol

Dmel\Vang^A3

Species

D. melanogaster

Name

FlyBase ID

FBal0093183

Feature type

allele

Associated gene

Dmel\Vang

Associated Insertion(s)

Carried in Construct

Also Known As

stbm^Vang-A3

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

gamma ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Taylor et al., 1998)

Mutagen

gamma ray

(Taylor et al., 1998)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity (with Vang^stbm-6)

(Strutt and Strutt, 2007)

abnormal planar polarity | recessive

(Taylor et al., 1998)

abnormal planar polarity | somatic clone

(Wu and Mlodzik, 2008)

abnormal planar polarity | somatic clone (with Df(2R)w45-30n)

(Strutt et al., 2002)

visible | recessive

(Taylor et al., 1998)

Phenotype Manifest In

adult abdomen

(Taylor et al., 1998)

adult thorax

(Taylor et al., 1998)

eye photoreceptor cell | somatic clone (with Df(2R)w45-30n)

(Strutt et al., 2002)

leg

(Taylor et al., 1998)

ommatidium (with Vang^stbm-6)

(Strutt and Strutt, 2007)

ommatidium | adult stage (with Vang^stbm-6)

(Cho et al., 2022)

ommatidium | somatic clone (with Df(2R)w45-30n)

(Strutt et al., 2002)

tarsal segment

(Taylor et al., 1998)

wing

(Taylor et al., 1998)

wing basal cell 1 & wing hair

(Taylor et al., 1998)

wing hair | somatic clone

(Wu and Mlodzik, 2008)

Detailed Description

Statement

Reference

Vang^A3 mutant clones non-autonomously reorient the wing hairs of neighbouring wild type cells so that they point away from the clone.

(Wu and Mlodzik, 2008)

Vang^stbm-6/Vang^A3 adults show defects in ommatidial patterning, with ommatidia pointing in random directions with randomised chirality.

(Strutt and Strutt, 2007)

48.0% of ommatidia in Df(2R)w45-30n/Vang^A3 mutant somatic clones in the eye are normal. 14.1% have rotated ommatidia, 36.8% have chirality defects, 0.9% are achiral (0.2% unscorable).

(Strutt et al., 2002)

Shows a weak and incompletely penetrant dominant wing hair phenotype, as well as the reliable recessive phenotype wing hair tissue polarity phenotype. Phenotype falls between that of the fz-like and in-like classes of phenotype. Clonal analysis with Vang^A3 reveals that Vang acts cell nonautonomously, and shows domineering nonautonomy.

(Taylor et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Vang^A3 has abnormal planar polarity | somatic clone phenotype, suppressible by fz²³

(Wu and Mlodzik, 2008)

Vang^A3 has abnormal planar polarity | somatic clone | cell non-autonomous phenotype, suppressible by pk^D

(Adler et al., 2000)

NOT Suppressor of

Statement

Reference

Vang^A3 is a non-suppressor of abnormal planar polarity | somatic clone phenotype of fz²³

(Wu and Mlodzik, 2008)

Other

Statement

Reference

Vang^A3, stan[+]/stan^E59 has abnormal neuroanatomy | third instar larval stage phenotype

(Matsubara et al., 2011)

Vang^A3, pk^D has abnormal planar polarity | somatic clone | cell non-autonomous phenotype

(Adler et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

Vang^A3 has phenotype, enhanceable by fz²³

(Taylor et al., 1998)

Vang^A3 has first basal wing cell phenotype, enhanceable by fz[+]/fz³⁰

(Taylor et al., 1998)

Suppressed by

Statement

Reference

Vang^A3 has wing hair | somatic clone phenotype, suppressible by fz²³

(Wu and Mlodzik, 2008)

Vang^A3 has wing | somatic clone | cell non-autonomous phenotype, suppressible by pk^D

(Adler et al., 2000)

Vang^A3 has phenotype, suppressible by fz³⁰

(Taylor et al., 1998)

Vang^A3 has phenotype, suppressible by pk¹

(Taylor et al., 1998)

Vang^A3 has phenotype, suppressible by pk^JJ13

(Taylor et al., 1998)

Vang^A3 has wing hair phenotype, suppressible by fz²⁵

(Taylor et al., 1998)

Enhancer of

Statement

Reference

Vang^A3 is an enhancer of phenotype of fz²⁴

(Taylor et al., 1998)

Suppressor of

Statement

Reference

Vang^A3 is a suppressor of phenotype of fz²³

(Taylor et al., 1998)

NOT Suppressor of

Statement

Reference

Vang^A3 is a non-suppressor of wing hair | somatic clone phenotype of fz²³

(Wu and Mlodzik, 2008)

Other

Statement

Reference

Vang^A3, stan[+]/stan^E59 has dendrite | third instar larval stage phenotype

(Matsubara et al., 2011)

Vang^A3, stan[+]/stan^E59 has larval dorsal multidendritic neuron ddaC | third instar larval stage phenotype

(Matsubara et al., 2011)

Vang^A3, pk^D has wing | somatic clone | cell non-autonomous phenotype

(Adler et al., 2000)

Vang^A3, fz¹ has wing hair phenotype

(Taylor et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

stan^E59/Vang^A3 double heterozygous larvae show increased crossing of dendrites in the dendritic arbor of the ddaC class IV neurons compared to wild type (neither single heterozygote shows this phenotype).

(Matsubara et al., 2011)

As is seen with fz²³ clones alone, fz²³ Vang^A3 double mutant clones non-autonomously reorient the wing hairs of neighbouring wild type cells so that they point towards the clone.

(Wu and Mlodzik, 2008)

Homozygous Vang^A3 clones in a pk^D background, all show significantly weaker domineering non-autonomy than seen in a wild-type background The non-autonomy is opposite to the direction of local hair polarity.

(Adler et al., 2000)

Double mutants of Vang^Tbs42, Vang^A3 or Vang^A5 with fz²⁴, dsh¹ in^unspecified and mwh^unspecified all showed hair polarity pattern typical of the fz-in group. Vang is epistatic to pk; double mutants of Vang^Tbs42, Vang^A3 or Vang^A5 with pk¹ show a fz-in group phenotype, possible less severe than for the Vang single mutant. Vang^A3 and Vang^Tbs42, but not Vang^11-3 act as dominant enhancers of the dominant phenotype of Df(2R)pk78s. Vang^A3 is a strong dominant enhancer of fz²⁴. In double mutant combinations between Vang^A3, Vang^A5 and Vang^Tbs42 with fz¹, fz²⁵ and fz³⁰, the fz-in type of polarity pattern was slightly less abnormal than in either single mutant. The domineering nonautonomy of Vang^A3 clones can be suppressed by fz²⁵ and fz³⁰. Vang^A3 suppresses the domineering nonautonomy of fz²³ clones.

(Taylor et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Vang^Tbs42

(Taylor et al., 1998)

Rescued by

Vang^stbm-6/Vang^A3 is rescued by Vang^Act5C.EYFP

(Strutt and Strutt, 2007)

Partially rescued by

Vang^stbm-6/Vang^A3 is partially rescued by Vang^UAS.cLa/Scer\GAL4^GMR.PY

(Cho et al., 2022)

Vang^stbm-6/Vang^A3 is partially rescued by Vang^sev.PS

(Strutt and Strutt, 2007)

Comments

Vang^{Act5C.T:Avic\GFP-EYFP} can rescue the wing planar polarity defects seen in Vang^stbm-6/Vang^A3 animals. Expression at 6 hours after puparium formation (APF) results in only minor polarity defects in the rescued wings. The rescue progressively worsens if expression is induced between 12 and 24 hours APF, with expression induced at 30 hours APF providing no rescue.

Vang^sev.PS partially rescues the ommatidial patterning defects of Vang^stbm-6/Vang^A3 adults. The ommatidial misrotation defect is largely rescued, but the dorsoventral inversion phenotype is not rescued.

(Strutt and Strutt, 2007)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Vang^A3

(Matsubara et al., 2011, Wu and Mlodzik, 2008)

stbm^A3

(Shimizu et al., 2011)

stbm^Vang-A3

(Strutt and Strutt, 2007, Strutt et al., 2002)

vang^A3

(Sanchez Bosch et al., 2024, Song et al., 2023, Cho et al., 2022, Cho et al., 2020, Cho et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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