FB2026_02 , released June 18, 2026
Allele: Dmel\Fs(2)KetP446L
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General Information
Symbol
Dmel\Fs(2)KetP446L
Species
D. melanogaster
Name
FlyBase ID
FBal0183524
Feature type
allele
Associated gene
Dmel\Fs(2)Ket
Associated Insertion(s)
Carried in Construct
P{Fs(2)KetP446L}
Key Links
Transgenic product class
dominant_negative_variant
(Timinszky et al., 2002)
missense_variant
(Timinszky et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Timinszky et al., 2002)
missense_variant
(Timinszky et al., 2002)
Mutagen
in vitro construct
(Timinszky et al., 2002)
Progenitor genotype
Fs(2)KetIII
(Timinszky et al., 2002)
Fs(2)Ket1
(Timinszky et al., 2002)
Carried in construct
P{Fs(2)KetP446L}
Cytology
Description

A fragment containing the lesion found in Fs(2)Ket1 (P446L) has been used to replace the corresponding region of Fs(2)KetIII. Amino acid replacement: P446L. Nucleotide substitution: C4114T.

(Timinszky et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
Fs(2)Ket
Encoded product / tool
Fs(2)Ket
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies that carry Fs(2)KetP446L are either sterile or their fertility is severely reduced.

      (Timinszky et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Fs(2)KetP446L
      Name Synonyms
      Secondary FlyBase IDs
        References (1)