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General Information
Symbol
Dmel\ph-p2
Species
D. melanogaster
Name
FlyBase ID
FBal0039750
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ph2
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

ph-p2 is a 10kb deletion that removes the 3' end of ph-p and the 5' end of ph-d. The breakpoint maps within a 1247bp region that is identicle between the two genes but cannot be further localized.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletion of approximately 10kb that joins the 5' end (promoter, untranslated leader and 5' coding sequences) of ph-p to the 3' end of ph-d (3' coding region and untranslated sequences) and removes all sequences in between.

Deletion of some of ph-d and some of ph-p.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

ph-p2/+ heterozygous mutant flies exhibit a higher than wild-type average number of legs with sex combs, with an average of 2.6 legs with sex combs, compared to 2.0 in wild-type, although this is not statistically significant.

Heterozygotes with Psc1 are lethal.

Hemizygous males usually have sex combs on the second and third legs, show a partial transformation of the posterior wing compartment towards the haltere and show a partial transformation of abdominal segment A4 towards A5, at both 25 and 29oC. Hemizygous males rarely show loss of the humerus and occasionally show partial transformation of abdominal segment A1 towards A2 at 25oC. At 29oC, both these phenotypes are more common. The expressivity and penetrance of these homeotic transformation phenotypes are comparable in ph-p2 and ph-p4 males.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

ph-p2 has sex comb phenotype, enhanceable by Hsc70-4195/Hsc70-4[+]

ph-p2 has leg phenotype, enhanceable by Df(2L)esc-P2-0

ph-p2 has sex comb phenotype, enhanceable by Df(2L)esc-P2-0

ph-p2 has leg phenotype, enhanceable by Df(2L)TW3

ph-p2 has sex comb phenotype, enhanceable by Df(2L)TW3

ph-p2 has leg phenotype, enhanceable by Df(2L)TW201

ph-p2 has sex comb phenotype, enhanceable by Df(2L)TW201

ph-p2 has leg phenotype, enhanceable by Df(2R)CA53

ph-p2 has sex comb phenotype, enhanceable by Df(2R)CA53

ph-p2 has leg phenotype, enhanceable by Df(2R)cn83c

ph-p2 has sex comb phenotype, enhanceable by Df(2R)cn83c

ph-p2 has leg phenotype, enhanceable by Df(3L)fz-GF3b

ph-p2 has sex comb phenotype, enhanceable by Df(3L)fz-GF3b

ph-p2 has leg phenotype, enhanceable by Df(2L)prd1.7

ph-p2 has leg phenotype, enhanceable by Df(3L)fz-GS1a

ph-p2 has sex comb phenotype, enhanceable by Df(3L)fz-GS1a

ph-p2 has leg phenotype, enhanceable by Df(3L)fz-CAL5

ph-p2 has sex comb phenotype, enhanceable by Df(3L)fz-CAL5

ph-p2 has sex comb phenotype, enhanceable by Df(2L)prd1.7

ph-p2 has leg phenotype, enhanceable by Df(2L)esc10

ph-p2 has sex comb phenotype, enhanceable by Df(2L)esc10

ph-p2 has leg phenotype, enhanceable by salm1

ph-p2 has sex comb phenotype, enhanceable by salm1

ph-p2 has leg phenotype, enhanceable by Df(2L)H20

ph-p2 has sex comb phenotype, enhanceable by Df(2L)H20

Suppressed by
Statement
Reference

ph-p2 has phenotype, suppressible by ph-d+tSa

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

ph-p2/Hsc70-4195 mutant flies exhibit a higher than wild-type average number of legs with sex combs, with a statistically significant average of 4.0 legs with sex combs, compared to 2.6 in ph-p2/+ heterozygotes.

ph-d2 ph-p2 homozygotes do not show a gap in the fourth wing vein at 25 or 29oC. 100% of ph-d2 ph-p2/+ ; en54/+ flies have a gap in the fourth wing vein at 29oC. 100% of ph-d2 ph-p2/+ ; en4/+ flies have a gap in the fourth wing vein at 29oC.

The extra sex combs phenotype of ph-p2 heterozygotes is dominantly enhanced by Df(2L)esc-P2-0, Df(2L)prd1.7, Df(2L)esc10, salm1, Df(2L)H20, Df(2L)TW3, Df(2L)TW201, Df(2R)CA53, Df(2R)cn83c, Df(3L)fz-GF3b, Df(3L)fz-GS1a and Df(3L)fz-CAL5. Lethal in heterozygous combination with Df(2L)Prl.

Males are completely rescued by ph-d+tSa.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)