FlyBase Allele Report: Hsap\KMT2A[UAS.C.Tag:FLAG]

General Information

Symbol

Hsap\KMT2A^{UAS.C.Tag:FLAG}

Species

H. sapiens

Name

FlyBase ID

FBal0269988

Feature type

allele

Associated gene

Hsap\KMT2A

Associated Insertion(s)

Carried in Construct

P{UAS-KMT2A.C.FLAG}

Key Links

Transgenic product class

wild_type

(Muyrers-Chen et al., 2004)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Muyrers-Chen et al., 2004)

Mutagen

in vitro construct

(Muyrers-Chen et al., 2004)

Progenitor genotype

Carried in construct

P{UAS-KMT2A.C.FLAG}

Cytology

Description

UAS regulatory sequences drive expression of full-length Hsap\KMT2A which is tagged at the C-terminal end with Tag:FLAG.

(Muyrers-Chen et al., 2004)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\KMT2A

Tagged with

Tag:FLAG

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle, with Scer\GAL4^da.G32

(Muyrers-Chen et al., 2004)

viable, with Scer\GAL4⁵⁰¹⁵

(Muyrers-Chen et al., 2004)

viable, with Scer\GAL4^Act5C.PU

(Muyrers-Chen et al., 2004)

viable, with Scer\GAL4^arm.PS

(Muyrers-Chen et al., 2004)

viable, with Scer\GAL4^Cg.PA

(Muyrers-Chen et al., 2004)

viable, with Scer\GAL4^da.G32

(Muyrers-Chen et al., 2004)

viable, with Scer\GAL4^en-e16E

(Muyrers-Chen et al., 2004)

viable, with Scer\GAL4^gcm.PU

(Muyrers-Chen et al., 2004)

viable, with Scer\GAL4^MZ1580

(Muyrers-Chen et al., 2004)

viable, with Scer\GAL4^T80

(Muyrers-Chen et al., 2004)

viable, with Scer\GAL4^Ugt36A1.PK

(Muyrers-Chen et al., 2004)

Phenotype Manifest In

Detailed Description

Statement

Reference

The pattern of BrdU incorporation is similar to wild type in the brains of larvae expressing Hsap\MLL^{Scer\UAS.C.T:Zzzz\FLAG} under the control of Scer\GAL4^da.G32. Analysis of BrdU labelling indicates that the cells show accelerated cell cycle progression compared to wild type. Chromatin structure appears normal in brain squashes of these larvae.

(Muyrers-Chen et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Hsap\KMT2A^{UAS.C.Tag:FLAG}/Scer\GAL4^{VP16.mat.αTub67C} is a suppressor of embryonic/first instar larval cuticle phenotype of trx^B11

(Muyrers-Chen et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\MLL^{Scer\UAS.C.T:Zzzz\FLAG} under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} partially rescues the cuticle pattern defects seen in trx^B11 homozygous embryos: 9% of embryos have a wild-type cuticle pattern.

(Muyrers-Chen et al., 2004)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\KMT2A^{Scer\UAS.C.T:Zzzz\FLAG}

Hsap\KMT2A^{UAS.C.Tag:FLAG}

Hsap\MLL^{Scer\UAS.C.T:Zzzz\FLAG}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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