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General Information
Symbol
Dmel\lawcEF520
Species
D. melanogaster
Name
FlyBase ID
FBal0007308
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

lawcEF520 causes early larval lethality. The 3% of lawcEF520/lawcp1 females that eclose have a lawc mutant phenotype including arista to leg transformation.

Lethal phase is during the embryonic to larval stages.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

lawc[+]/lawcEF520 is an enhancer of visible | dominant | homeotic phenotype of brm2, trx[+]/trxE2

lawc[+]/lawcEF520 is an enhancer of visible | dominant | homeotic phenotype of brm[+]/brm2, trxE2

lawc[+]/lawcEF520 is an enhancer of visible | dominant | homeotic phenotype of ash1[+]/ash117, trxB11

lawcEF520 is an enhancer of visible | homeotic phenotype of ash117, trxB11

lawc[+]/lawcEF520 is an enhancer of visible | dominant | homeotic phenotype of ash117, trxB11/trx[+]

NOT Enhancer of
Statement
Reference

lawcEF520 is a non-enhancer of visible | dominant | homeotic phenotype of brm2

lawcEF520 is a non-enhancer of visible | dominant | homeotic phenotype of trxB11

lawcEF520 is a non-enhancer of visible | dominant | homeotic phenotype of ash117

Other
Phenotype Manifest In
Enhancer of
Statement
Reference

lawc[+]/lawcEF520 is an enhancer of haltere phenotype of ash117, trxB11/trx[+]

lawcEF520 is an enhancer of metathoracic leg phenotype of ash117, trxB11

NOT Enhancer of
Statement
Reference

lawcEF520 is a non-enhancer of eye phenotype of CycEJP

NOT Suppressor of
Statement
Reference

lawcEF520 is a non-suppressor of eye phenotype of CycEJP

Additional Comments
Genetic Interactions
Statement
Reference

Does not enhance the frequency of homeotic transformations of trxB11, brm2 or ash117 single heterozygotes. The frequency of homeotic transformations in trxB11 ash117 or brm2 trxE2 double heterozygotes is dominantly enhanced by lawcEF520. lawcp1/lawcEF520 females are viable. However, in combination with trxB11, brm2 or ash117, lawcp1/lawcEF520 results in lethality. lawcp1/Df(1)RA2 females are viable. However, in combination with trxB11, brm2 or ash117, lawcp1/Df(1)RA2 results in lethality.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The reduced female receptivity phenotype of Nrgibx is complemented by lawcEF520.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

Lefevre.

Comments
Comments

Maternal germline clonal analysis demonstrates cell lethality in homozygous clones.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (10)