FlyBase Gene Report: Dmel\lawc

General Information

Symbol

Dmel\lawc

Species

D. melanogaster

Name

leg arista wing complex

Annotation Symbol

CG32711

Feature Type

protein_coding_gene

FlyBase ID

FBgn0262976

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

7E6-7E7

Sequence location

X:8,408,008..8,411,658 [-]

Recombination map

1-23

RefSeq locus

NC_004354 REGION:8408008..8411658

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (2 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in polytene chromosome interband

inferred from direct assay

(Brandt and Corces, 2008)

located_in polytene chromosome puff

inferred from direct assay

(Brandt and Corces, 2008)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\lawc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q8SXG2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Existence of gene as protein-coding supported by FBrf0207164.

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0071248

1072

FBtr0302081

1332

FBtr0307286

2632

FBtr0307287

1870

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

lawc-PA

FBpp0071191

8.0

8.25

FBpp0291291

8.0

8.25

FBpp0298287

8.0

8.25

FBpp0298288

8.0

8.25

Q8SXG2

NP_001245580

AFH07294

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

73 aa isoforms: lawc-PA, lawc-PB, lawc-PC, lawc-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lawc using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.16

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

organism

(Mela et al., 2009)

Additional Descriptive Data

Expression is observed in a number of tissues in a wiser^ts1 background including ventral midline glial cells, PNS, tracheal pits, gut and hemocytes in embryos, eye-antennal, wing and leg imaginal discs, CNS, and lymph glands in third instar larvae, and adult ovaries.

(Mela et al., 2009)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

organism

(Mela et al., 2009)

adult stage

organism

(Mela et al., 2009)

Additional Descriptive Data

Differential developmental expression of two protein isoforms is observed. Expression is observed in a number of tissues in a wiser^ts1 background including ventral midline and glial cells, PNS, and tracheal system in embryos and in nurse cells in oocytes.

(Mela et al., 2009)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in polytene chromosome interband

inferred from direct assay

(Brandt and Corces, 2008)

located_in polytene chromosome puff

inferred from direct assay

(Brandt and Corces, 2008)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\lawc in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\lawc

View exonic expression by tissue for Dmel\lawc

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0262976

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

318164/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0262976

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052711

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0262976

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32711

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 17 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of lawc

Transgenic constructs containing regulatory region of lawc

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

Df(1)RA2

(Zorin et al., 1999)

Gene not disrupted in

Df(1)KA14

(Zorin et al., 1999)

Gene partially disrupted in

Df(1)cd1-54

(Cherezov et al., 2025)

Df(1)cd1-510

(Cherezov et al., 2025)

Inferred from location ( 14 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

cell lethal | germline clone

lawc^EF520

lethal

lawc^EF520

lethal | recessive

lawc^EF520

lethal - all die before end of larval stage | recessive

lawc^EF520

partially lethal - majority die, with Scer\GAL4^pnr-MD237

lawc^GD15874

partially lethal - majority die | recessive

lawc^p1

partially lethal - majority live

lawc^pdel

viable

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

lawc^GD15874

enhancer of variegation, with bw^D

lawc^p1

enhancer of variegation, with In(1)w^m4

lawc^p1

enhancer of variegation, with y^v2

lawc^p1

some die during larval stage | recessive

lawc^EF520

some die during pupal stage, with Scer\GAL4^pnr-MD237

lawc^GD15874

visible

lawc^p1

visible | homeotic

Phenotype manifest in

Allele

adult thorax

lawc^p1

adult thorax & macrochaeta

lawc^p1

arista

eye

lawc^p1

leg | ectopic

lawc^p1

macrochaeta

lawc^p1

macrochaeta | ectopic

lawc^p1

mesonotum, with Scer\GAL4^pnr-MD237

lawc^GD15874

scutellar bristle

lawc^p1

scutellum

lawc^p1

tarsal segment | ectopic

lawc^unspecified

thorax

lawc^pdel

wing

lawc^p1

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:lawc. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

lawc - Prosβ3

experimental knowledge based

(Guruharsha et al., 2011)

lawc - ref(2)P

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

lawc

enhanceable

Prosβ6

(Brandt and Corces, 2008)

brm|lawc

enhanceable

trx

(Zorin et al., 1999)

lawc

enhanceable

trx|brm

(Zorin et al., 1999)

lawc

enhanceable

trx|ash1

(Zorin et al., 1999)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

ash1|trx

enhanceable

lawc

(Zorin et al., 1999)

mod(mdg4)

suppressible

lawc

(Zorin et al., 1999)

suppressible

lawc

(Zorin et al., 1999)

Snr1

enhanceable

lawc

(Marenda et al., 2004)

trx|brm

enhanceable

lawc

(Zorin et al., 1999)

trx|ash1

enhanceable

lawc

(Zorin et al., 1999)

y|mod(mdg4)

suppressible

lawc

(Zorin et al., 1999)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0262976

MIST (protein-protein) - An integrated Molecular Interaction Database

318164

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-23

Cytogenetic map

7E6-7E7

Sequence location

X:8,408,008..8,411,658 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

7E6-7E7

Limits computationally determined from genome sequence between P{EP}CG1632^EP1583 and P{EP}Moe^EP1652

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

7F-7F

(determined by in situ hybridisation)

(Simonova et al., 1992)

7E4-7E4

(Perrimon et al., 1989)

Experimentally Determined Recombination Data

Location

1-23

(FlyBase, 2016)

1-23.4

(Comeron et al., 2012)

1-23.0

(Simonova et al., 1997, Simonova et al., 1992)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

4682

lawc^EF520/FM7a

17477

y¹ w^67c23 P{EPgy2}lawc^EY08588

11546

w^67c23 P{lacW}Trf2^G0039 lawc^G0039/FM7c

107835

v103446

v48418

w¹¹¹⁸; P{GD15874}v48418

Genomic Clones (24)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (25)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RH09582

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0262976

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Mela et al., 2009, Brandt and Corces, 2008)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

New annotation (CG32711) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Mutants show approximately half the normal perception to attractant odours.

(Simonova et al., 2000)

lawc is a member of the trithorax-group of genes.

(Zorin et al., 1999)

Mutations in lawc enhance the phenotype of trithorax-group mutations and suppress the phenotype of Polycomb-group mutations.

(Zorin et al., 1999)

lawc gene may encode a factor determining the specific expression of the ac-sc genes.

(Simonova et al., 1996)

Relationship to Other Genes

Source for database merge of

Source for merge of: lawc l(1)7Ea

(Simonova et al., 1997)

Source for merge of: CG32711 BcDNA:RH09582

(FlyBase, 1996-)

Source for merge of: lawc CG32711

(Brandt and Corces, 2008)

Additional comments

Source for merge of CG32711 BcDNA:RH09582 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

BcDNA:RH09582

CG32711

(Ida et al., 2009, Keleman et al., 2009.8.5, Mela et al., 2009, Brandt and Corces, 2008, Shima et al., 2007, Lin and Kellis, 2006.12.15)

l(1)7Ea

lawC

(Brumby et al., 2002)

lawc

(Cherezov et al., 2020, Brandt and Corces, 2008, Olga et al., 2008, Carhan et al., 2005)

Name Synonyms

leg arista wing complex

leg-arista-wing complex

(Brandt and Corces, 2008, Olga et al., 2008)

lethal(1)7Ea

Secondary FlyBase IDs

FBgn0001460
FBgn0005688
FBgn0052711
FBgn0063662

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

318164

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q8SXG2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q8SXG2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q8SXG2

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0262976

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

318164/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0262976

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0262976

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG32711

MARRVEL_MODEL - MARRVEL (model organism gene)

318164

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0262976

DroID - A comprehensive database of gene and protein interactions.

FBgn0262976

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052711

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0262976

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32711

MIST (protein-protein) - An integrated Molecular Interaction Database

318164

References (64)

The following external sites may use different assemblies or annotations than FlyBase.

-1.16

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