FB2026_02 , released June 18, 2026
Allele: Dmel\wiserts1
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General Information
Symbol
Dmel\wiserts1
Species
D. melanogaster
Name
FlyBase ID
FBal0221776
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description

P-element insertion after nucleotide 8304617 (release 5.1 genome), which is located 490bp upstream of the presumed transcription start site of CG32711.

Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

32.62% of homozygous larvae die at 19[o]C. 60.88% of homozygotes eclose as adults at this temperature. These flies have scalloped wings. The scalloped phenotype is variable, ranging from middle scalloping in the posterior to strong scalloping in the anterior and posterior compartments. The strong phenotype is more frequent in females than in males.

40.75% of homozygous larvae and 14.23% of homozygous pupae die at 25[o]C. 49.10% of the animals eclose as adults at this temperature.

52.57% of homozygous larvae and 100% of homozygous pupae die at 29[o]C. None of the homozygotes eclose as adults at this temperature. Animals that are helped to emerge are sometimes unable to move the lower abdomen, usually have deformed tarsal segments of the T3 leg and die in less than 3 hours.

Homozygous flies raised to adulthood at 19[o]C and then incubated at 29[o]C show a dramatic reduction in lifespan compared to control flies. The death rate is higher in mutant males than in mutant females from the second to the sixth day.

wiserts1/Df(1)RA2 results in lethality at both 19[o]C and 29[o]C. wiserts1/Df(1)RA2 adult escapers have a strong scalloped wing phenotype in the anterior and posterior compartments, smaller and rougher eyes than normal, deformed T3 legs, locomotor defects, are sterile with deformed ovaries and die after 1-4 days.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Excision of the P-element insertion reverts the mutant phenotype.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)