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General Information
Symbol
Dmel\mxcG48
Species
D. melanogaster
Name
FlyBase ID
FBal0046151
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G9243101A

Reported nucleotide change:

G?A

Comment:

Splice acceptor site mutation (AG to AA) at the first intron/second exon border.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Splice acceptor site mutation (AG to AA) at the first intron/second exon border.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Hemizygous embryos hatch with normal cuticles. No transformation of anterior segments toward abdominal segment A8 is seen. These larvae are smaller than wild-type and attain the second instar with approximately a 24 hour delay. Most of the larvae die several days later without undergoing a second moult. All the major imaginal discs are smaller than in wild-type larvae. Almost all second instar larvae have melanotic pseudotumours. Areas of melanisation are seen touching the imaginal hindgut ring and hindgut. Mitotic figures and metaphase chromosome morphology of larval brain squashes do not show striking anomalies.

Homozygotes die as first or second instar larvae. mxcG9/mxc22a-6 females lay many small eggs with a thin chorion and small dorsal appendages that collapse after oviposition. mxcM1/mxcG48 females have reduced viability and do not lay eggs. Some egg chambers contain the normal number of nurse cells, but oogenesis appears arrested before stage 7-8. Egg chambers degenerate in older flies. mxcG46/mxcG48 females have reduced viability, rudimentary gonads and do not lay eggs. The sheaths of the somatic cells that organise the ovarioles are still present and all structures derived from genital imaginal disc appear similar to wild-type.

Homozygotes die at the embryonic/larval interface. Most mxcG48 heterozygotes with mxc1 or mxcSO die in the third instar with blood cell tumors.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

mxc[+]/mxcG48 is an enhancer of visible | dominant | homeotic phenotype of ash117, trxB11/trx[+]

Phenotype Manifest In
NOT suppressed by
Statement
Reference

mxcG48 has phenotype, non-suppressible by ftG

Enhancer of
Statement
Reference

mxc[+]/mxcG48 is an enhancer of adult metathoracic segment phenotype of ash117, trxB11/trx[+]

Suppressor of
Statement
Reference

mxcG48 is a suppressor of tergite phenotype of hb4, nosL7

mxcG48 is a suppressor of phenotype of z1

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Significantly rescues the lack of abdominal segment differentiation seen in the progeny of hb4 nosL7/nosL7 females. Adult escapers have abnormal tergites and are mostly fertile. ftG has no rescuing effect on mxcG48.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments

mxcUbi.T:Avic\GFP rescues the lethality caused by mxcG48.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

The alleles of mxc form a series. From weakest phenotype to strongest phenotype: mxcG9 < mxcM1 < mxcG46 < mxcG43 < mxcSO < mxc1 < mxcG48.

Germline clonal analysis indicates that mxc+ function is required in the female germline.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (9)