FlyBase Allele Report: Dmel\mxc[G48]

General Information

Symbol

Dmel\mxc^G48

Species

D. melanogaster

Name

FlyBase ID

FBal0046151

Feature type

allele

Associated gene

Dmel\mxc

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Docquier et al., 1996)

Mutagen

ethyl methanesulfonate

(Santamaria and Randsholt, 1995)

Progenitor genotype

Cytology

Description

Splice acceptor site mutation (AG to AA) at the first intron/second exon border.

(White et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:9,243,101..9,243,101 [-]

Nucleotide change:

G9243101A

Reported nucleotide change:

G?A

Comment:

Splice acceptor site mutation (AG to AA) at the first intron/second exon border.

(White et al., 2011)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased fecundity | female (with mxc^G46)

(Docquier et al., 1996)

decreased fecundity | female (with mxc^M1)

(Docquier et al., 1996)

lethal | recessive

(Santamaria and Randsholt, 1995)

lethal - all die before end of larval stage | recessive

(Saget et al., 1998, Docquier et al., 1996)

some die during larval stage | recessive

(Saget et al., 1998, Docquier et al., 1996)

Phenotype Manifest In

dorsal appendage

(Docquier et al., 1996)

egg

(Docquier et al., 1996)

egg chamber

(Docquier et al., 1996)

egg chorion

(Docquier et al., 1996)

imaginal disc

(Saget et al., 1998)

melanotic mass

(Saget et al., 1998)

pigment cell

(Santamaria and Randsholt, 1995)

Detailed Description

Statement

Reference

Hemizygous embryos hatch with normal cuticles. No transformation of anterior segments toward abdominal segment A8 is seen. These larvae are smaller than wild-type and attain the second instar with approximately a 24 hour delay. Most of the larvae die several days later without undergoing a second moult. All the major imaginal discs are smaller than in wild-type larvae. Almost all second instar larvae have melanotic pseudotumours. Areas of melanisation are seen touching the imaginal hindgut ring and hindgut. Mitotic figures and metaphase chromosome morphology of larval brain squashes do not show striking anomalies.

(Saget et al., 1998)

Homozygotes die as first or second instar larvae. mxc^G9/mxc^22a-6 females lay many small eggs with a thin chorion and small dorsal appendages that collapse after oviposition. mxc^M1/mxc^G48 females have reduced viability and do not lay eggs. Some egg chambers contain the normal number of nurse cells, but oogenesis appears arrested before stage 7-8. Egg chambers degenerate in older flies. mxc^G46/mxc^G48 females have reduced viability, rudimentary gonads and do not lay eggs. The sheaths of the somatic cells that organise the ovarioles are still present and all structures derived from genital imaginal disc appear similar to wild-type.

(Docquier et al., 1996)

Homozygotes die at the embryonic/larval interface. Most mxc^G48 heterozygotes with mxc¹ or mxc^SO die in the third instar with blood cell tumors.

(Santamaria and Randsholt, 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

mxc[+]/mxc^G48 is an enhancer of visible | dominant | homeotic phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

mxc^G48 has phenotype, non-suppressible by ft^G

(Saget et al., 1998)

Enhancer of

Statement

Reference

mxc[+]/mxc^G48 is an enhancer of adult metathoracic segment phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

Suppressor of

Statement

Reference

mxc^G48 is a suppressor of embryonic abdominal segment phenotype of hb⁴, nanos^L7

(Saget et al., 1998)

mxc^G48 is a suppressor of abdominal tergite phenotype of hb⁴, nanos^L7

(Saget et al., 1998)

mxc^G48 is a suppressor of phenotype of z¹

(Santamaria and Randsholt, 1995)

Other

Statement

Reference

hb⁴, mxc^G48, nanos^L7 has abdominal tergite phenotype

(Saget et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Significantly rescues the lack of abdominal segment differentiation seen in the progeny of hb⁴ nos^L7/nos^L7 females. Adult escapers have abnormal tergites and are mostly fertile. ft^G has no rescuing effect on mxc^G48.

(Saget et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

mxc^G48 is rescued by mxc^Ubi-p63E.GFP

(White et al., 2011)

Comments

mxc^{Ubi.T:Avic\GFP} rescues the lethality caused by mxc^G48.

(White et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

7141

y¹ ac¹ mxc^G48/FM7a

Notes on Origin

Discoverer

Comments

The alleles of mxc form a series. From weakest phenotype to strongest phenotype: mxc^G9 < mxc^M1 < mxc^G46 < mxc^G43 < mxc^SO < mxc¹ < mxc^G48.

(Santamaria and Randsholt, 1995)

Germline clonal analysis indicates that mxc⁺ function is required in the female germline.

(Docquier et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

mxc^G48

(Hur et al., 2020, Kurihara et al., 2020, Tatomer et al., 2016, Terzo et al., 2015, Landais et al., 2014, White et al., 2011, Randsholt, 2009.1.22, Sofola et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (12)

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