FlyBase Allele Report: Dmel\hb[4]

General Information

Symbol

Dmel\hb⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0005395

Feature type

allele

Associated gene

Dmel\hb

Associated Insertion(s)

Carried in Construct

Also Known As

hb^7M, hb^7M48

Key Links

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Qian et al., 1991, Harding and Levine, 1988, Tautz, 1988)

loss of function allele

(Lukowitz et al., 1994)

Mutagen

ethyl methanesulfonate

(Lehmann and Nusslein-Volhard, 1987, Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Stop codon before the first finger domain.

(Lukowitz et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

gap phenotype | embryonic stage | recessive

(Lehmann and Nusslein-Volhard, 1987)

lethal - all die during embryonic stage | recessive

Phenotype Manifest In

embryonic/first instar larval cuticle

(Lukowitz et al., 1994)

embryonic neuroblast

(Kambadur et al., 1998)

larval longitudinal connective

(Kambadur et al., 1998)

mitotic domain 1 | extended germ band stage

(Irvine and Wieschaus, 1994)

symmetrical commissure

(Kambadur et al., 1998)

Detailed Description

Statement

Reference

Stage 13 ventral cords exhibit lack of longitudinal connectives, missing or disorganised commissures. Increase in the number of neuroblast sublineages expressing nub in all CNS ganglia.

(Kambadur et al., 1998)

hb, kni double mutants show reduced rate of germ band extension. Cell intercalation is reduced in the region where the germ band fails to narrow, i.e. the region where eve and other pair-rule gene expression is uniform.

(Irvine and Wieschaus, 1994)

Cuticle phenotype.

(Lukowitz et al., 1994)

kni¹⁰ hb⁴ double mutant embryos fail to undergo normal germ band extension.

(Leptin et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

fkh¹, hb⁴, kni¹⁰, tll¹ has abnormal cell polarity | gastrula stage phenotype

(Zallen and Wieschaus, 2004)

Phenotype Manifest In

Suppressed by

Statement

Reference

hb⁴, nanos^L7 has embryonic abdominal segment phenotype, suppressible by mxc^G48

(Saget et al., 1998)

hb⁴, nanos^L7 has embryonic abdominal segment phenotype, suppressible by Df(2R)vg-B

(Saget et al., 1998)

hb⁴, nanos^L7 has embryonic abdominal segment phenotype, suppressible | partially by pho^b

(Saget et al., 1998)

hb⁴, nanos^L7 has abdominal tergite phenotype, suppressible by mxc^G48

(Saget et al., 1998)

Suppressor of

Statement

Reference

hb⁴ is a suppressor of embryonic abdominal segment phenotype of nanos^L7

(Bajusz et al., 2001)

Other

Statement

Reference

hb⁴, nanos^L7 has embryonic abdominal segment phenotype

(Saget et al., 1998)

hb⁴, nanos^L7 has abdominal 7 ventral denticle belt phenotype

(Saget et al., 1998)

hb⁴, nanos^L7 has abdominal 4 ventral denticle belt phenotype

(Saget et al., 1998)

hb⁴, mxc^G48, nanos^L7 has abdominal tergite phenotype

(Saget et al., 1998)

hb⁴, nanos^L7 has abdominal 5 ventral denticle belt phenotype

(Saget et al., 1998)

hb⁴, nanos^L7 has abdominal 8 ventral denticle belt phenotype

(Saget et al., 1998)

hb⁴, nanos^L7 has abdominal tergite phenotype

(Saget et al., 1998)

hb⁴, nanos^L7 has abdominal 1 ventral denticle belt phenotype

(Saget et al., 1998)

hb⁴, nanos^L7 has abdominal 2 ventral denticle belt phenotype

(Saget et al., 1998)

hb⁴, nanos^L7 has abdominal 3 ventral denticle belt phenotype

(Saget et al., 1998)

hb⁴, nanos^L7 has abdominal 6 ventral denticle belt phenotype

(Saget et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Anterior-posterior polarization of cells in the extending germband is disrupted in kni¹⁰ hb⁴ fkh¹ tll¹ homozygous embryos.

(Zallen and Wieschaus, 2004)

3.69% of embryos derived from hb⁴ nos^L7/nos^L7 females have at least 3 abdominal segments.

(Bajusz et al., 2001)

Embryos derived from hb⁴ nos^L7/nos^L7 females differentiate only a few abdominal denticle belts. No rescue of abdominal segments is seen if the females also carry Df(1)10-70d, Df(1)mxc-1, mxc^22a-6 or mxc¹. Rescue of abdominal segments in embryos derived from hb⁴ nos^L7/nos^L7 females is seen if the females are also carrying mxc^G48. Adult escapers have abnormal tergites and are mostly fertile. Rescue of abdominal segments in embryos derived from hb⁴ nos^L7/nos^L7 females is seen if the females are also carrying Df(2R)vg-B or pho^b.

(Saget et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

hb⁴ is partially rescued by hb^hb.0.7bcd

(Lukowitz et al., 1994)

hb⁴ is partially rescued by hb^{Dvir\hb.0.8bcd}

(Lukowitz et al., 1994)

Comments

Head segments and thoracic segments (except for T2) can be rescued by hb^hb.0.7bcd or hb^{Dvir\hb.0.8bcd}.

(Lukowitz et al., 1994)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

5339

P{ftz-lacC}4; kni¹⁰ hb⁴ e^s/TM3, Sb¹

Kyoto

106971

kni¹⁰ hb⁴ cu¹ sr¹ e^s ca¹ / TM3, Sb¹

Notes on Origin

Discoverer

Comments

Class I allele.

hb^Drv2 fails to complement hb⁴.

(Duncan, 1986)

Phenotypic class I.

(Lehmann and Nusslein-Volhard, 1987)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

hb⁴

hb^7M48

(Riede, 2004, Zallen and Wieschaus, 2004, Kuhnlein et al., 1998, Kuhnlein et al., 1997, Wimmer et al., 1995, Irvine and Wieschaus, 1994, Jack and McGinnis, 1990, Hooper et al., 1989, Harding and Levine, 1988, Frasch and Levine, 1987)

hb^7M

(Bajusz et al., 2001, Wimmer et al., 2000, Saget et al., 1998, Hartmann et al., 1994, Lukowitz et al., 1994, Pelegri and Lehmann, 1994, Leptin et al., 1992, Zhang and Bienz, 1992, Hoch et al., 1991, Qian et al., 1991, Zhang et al., 1991, Tautz, 1988, Lehmann and Nusslein-Volhard, 1987, Tearle and Nusslein-Volhard, 1987)

hb^7m48

(Langeland et al., 1994, Duncan, 1986)

hunchback^7M48

(Dey et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (29)

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