FlyBase Allele Report: Dmel\kni[10]

General Information

Symbol

Dmel\kni¹⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0005780

Feature type

allele

Associated gene

Dmel\kni

Associated Insertion(s)

Carried in Construct

Also Known As

kni^IID48, kni^IID, kni^2D48

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Irish et al., 1989, Harding and Levine, 1988)

loss of function allele

(Kraut and Levine, 1991)

Mutagen

ethyl methanesulfonate

(Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

mitotic domain 1 | extended germ band stage

(Irvine and Wieschaus, 1994)

Detailed Description

Statement

Reference

hb, kni double mutants show reduced rate of germ band extension. Cell intercalation is reduced in the region where the germ band fails to narrow, i.e. the region where eve and other pair-rule gene expression is uniform.

(Irvine and Wieschaus, 1994)

kni¹⁰ hb⁴ double mutant embryos fail to undergo normal germ band extension.

(Leptin et al., 1992)

Premature reduction of gt protein in the posterior domain. In the head region the middle stripe persists as an unbroken band covering the entire ventral side.

(Kraut and Levine, 1991)

Interacts with RpII140^wimp maternal effect.

(Parkhurst and Ish-Horowicz, 1991)

Posterior gt expression domain fails to narrow completely to a stripe during cellularization.

(Mohler et al., 1989)

strong

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

fkh¹, hb⁴, kni¹⁰, tll¹ has abnormal cell polarity | gastrula stage phenotype

(Zallen and Wieschaus, 2004)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Anterior-posterior polarization of cells in the extending germband is disrupted in kni¹⁰ hb⁴ fkh¹ tll¹ homozygous embryos.

(Zallen and Wieschaus, 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

5339

P{ftz-lacC}4; kni¹⁰ hb⁴ e^s/TM3, Sb¹

Kyoto

106971

kni¹⁰ hb⁴ cu¹ sr¹ e^s ca¹ / TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

IID

(Shimell et al., 2000)

kni¹⁰

(Clyde et al., 2003)

kni^2D48

(Casares and Sanchez-Herrero, 1995, Irish et al., 1989)

kni^2D

(Mohler et al., 1989)

kni^IID48

(Zallen and Wieschaus, 2004, Small et al., 1996, Gonzalez-Crespo and Levine, 1994, Irvine and Wieschaus, 1994, Langeland et al., 1994, Kraut and Levine, 1991, Parkhurst and Ish-Horowicz, 1991, Riddihough and Ish-Horowicz, 1991, Riley et al., 1991, Goto et al., 1989, Hooper et al., 1989, Harding and Levine, 1988, Frasch and Levine, 1987)

kni^IID

(Wimmer et al., 2000, Halfon et al., 1995, Busturia and Bienz, 1993, Gutjahr et al., 1993, Leptin et al., 1992, Lehmann and Nusslein-Volhard, 1987, Tearle and Nusslein-Volhard, 1987)

knirps^IID48

(Dey et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (27)

Report Sections

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