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General Information
Symbol
Dmel\fkh1
Species
D. melanogaster
Name
FlyBase ID
FBal0004007
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
fkhE200
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G28583792A

Reported nucleotide change:

G?A

Amino acid change:

W254term | fkh-PA; W254term | fkh-PB; W254term | fkh-PC; W254term | fkh-PD; W254term | fkh-PE

Reported amino acid change:

W254term

Comment:

TGG to TGA

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: W254term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

During embryogenesis the salivary secretory cells fail to invaginate and eventually disappear. Salivary duct cells also fail to invaginate to form tubes but do occasionally invaginate to form a teardrop-shaped structure.

Most of the gut epithelium degenerates during stages 12/13, generating a high level of cell death. All interior hemocytes become macrophages at an early stage. Hemocytes are attracted to the region of cell death from more superficial levels.

Defective in gonad assembly.

Failure of head involution. Homeotic transformations in the pre-oral head region and the foregut. Posterior tail region and the hindgut are homeotically replaced by anterior tail and post-oral head. Embryos lack oesophagus, proventriculus, hindgut and Malpighian tubules.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The body weight of TorΔP/+ flies is increased by the presence of fkh1/+.

Anterior-posterior polarization of cells in the extending germband is disrupted in kni10 hb4 fkh1 tll1 homozygous embryos.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (16)