FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\scf1
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General Information
Symbol
Dmel\scf1
Species
D. melanogaster
Name
FlyBase ID
FBal0243716
Feature type
allele
Associated gene
Dmel\scf
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ogasawara et al., 2007)
Progenitor genotype
Cytology
Description

Amino acid replacement: W271term.

(Ogasawara et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:1,299,655..1,299,655 [+]
Nucleotide change:

G1299655A

Amino acid change:

W271term | scf-PA; W134term | scf-PB

Reported amino acid change:

W271term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Ogasawara et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous adults do not show significant anterior transformations.

      (Ogasawara et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      scf1/scf[+] is an enhancer of visible | dominant | homeotic | male phenotype of trxB11

      (Ogasawara et al., 2007)

      scf1/scf[+] is an enhancer of visible | dominant | homeotic | male phenotype of Polr2BZ43

      (Ogasawara et al., 2007)
      Suppressor of
      Statement
      Reference

      scf1/scf[+] is a suppressor of visible | dominant | homeotic phenotype of Pc3

      (Ogasawara et al., 2007)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      scf1/scf[+] is an enhancer of adult abdominal segment 6 | male phenotype of trxB11

      (Ogasawara et al., 2007)

      scf1/scf[+] is an enhancer of adult abdominal segment 5 | ectopic | male phenotype of trxB11

      (Ogasawara et al., 2007)

      scf1/scf[+] is an enhancer of adult abdominal segment 6 | male phenotype of Polr2BZ43

      (Ogasawara et al., 2007)

      scf1/scf[+] is an enhancer of adult abdominal segment 5 | ectopic | male phenotype of Polr2BZ43

      (Ogasawara et al., 2007)
      Suppressor of
      Statement
      Reference

      scf1/scf[+] is a suppressor of adult abdominal segment 4 | male phenotype of Pc3

      (Ogasawara et al., 2007)

      scf1/scf[+] is a suppressor of adult abdominal segment 5 | ectopic | male phenotype of Pc3

      (Ogasawara et al., 2007)

      scf1/scf[+] is a suppressor of abdominal tergite 4 | male phenotype of Pc3

      (Ogasawara et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The penetrance of the ectopic pigmentation phenotype seen in the A4 tergite of Pc3/+ males is reduced from 59.2% to 30.6% if they are also heterozygous for scf1.

      scf1/+ significantly enhances the penetrance of the A6 to A5 transformation phenotype that is seen in trxB11/+ and in RpII140Z43/+ males.

      (Ogasawara et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      scf1 is rescued by scf+tOa

      (Ogasawara et al., 2007)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      J2.4
      (Ogasawara et al., 2007)
      scf1
      (Ogasawara et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)